Design and characterization of a heterobifunctional degrader of KEAP1

por Chen, Hao, Nguyen, Nghi H., Magtoto, Charlene M., Cobbold, Simon A., Bidgood, Grace M., Meza Guzman, Lizeth G., Richardson, Lachlan W., Corbin, Jason, Au, Amanda E., Lechtenberg, Bernhard C., Feltham, Rebecca, Sutherland, Kate D., Grohmann, Christoph, Nicholson, Sandra E., Sleebs, Brad E.
Publicado 2022

OTHR-02. CHIMERIC AURORA A KINASE (AURKA) DEGRADERS EFFICIENTLY TARGET N-MYC

por Valinciute, Gintvile, Eing, Lorenz, Mihalic, Jeffrey, Casey, Colleen E, Tian, Hua, Adhikari, Bikash, Guiducci, Cristiana, Rountree, Ryan, Grohmann, Christoph, Sridharan, Sangita, Lu, Ya-Wen, Vezina-Dawod, Simon, Wegrzyniak, Eric, Chaterjee, Abhinav, Hansen, Gwenn M, Maris, John M, Mossé, Yael P, Eilers, Martin, Wolf, Elmar, Roussel, Martine F
Publicado 2023

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

por Pierotti, Catia L., Jacobsen, Annette V., Grohmann, Christoph, Dempsey, Ruby K., Etemadi, Nima, Hildebrand, Joanne M., Fitzgibbon, Cheree, Young, Samuel N., Davies, Katherine A., Kersten, Wilhelmus J. A., Silke, John, Lowes, Kym N., Jousset Sabroux, Hélène, Huang, David C. S., van Delft, Mark F., Murphy, James M., Lessene, Guillaume
Publicado 2023

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

por Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca
Publicado 2022

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

por Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Publicado 2020

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

por Grohmann, Christoph, Walker, Francesca, Devlin, Mark, Luo, Meng-Xiao, Chüeh, Anderly C., Doherty, Judy, Vaillant, François, Ho, Gwo-Yaw, Wakefield, Matthew J., Weeden, Clare E., Kamili, Alvin, Murray, Jayne, Po’uha, Sela T., Weinstock, Janet, Kane, Serena R., Faux, Maree C., Broekhuizen, Esmee, Zheng, Ye, Shield-Artin, Kristy, Kershaw, Nadia J., Tan, Chin Wee, Witchard, Helen M., Ebert, Gregor, Charman, Susan A., Street, Ian, Kavallaris, Maria, Haber, Michelle, Fletcher, Jamie I., Asselin-Labat, Marie-Liesse, Scott, Clare L., Visvader, Jane E., Lindeman, Geoffrey J., Watson, Keith G., Burgess, Antony W., Lessene, Guillaume
Publicado 2021