Clinical trial diversity: An opportunity for improved insight into the determinants of variability in drug response

por Gross, Annette S., Harry, Anya C., Clifton, Christine S., Della Pasqua, Oscar
Publicado 2022

Application of physiologically based pharmacokinetic modeling to understand real‐world outcomes in patients receiving imatinib for chronic myeloid leukemia

por Adattini, Josephine A., Adiwidjaja, Jeffry, Gross, Annette S., McLachlan, Andrew J.
Publicado 2023

Insights into dasatinib use and outcomes in real-world patients with chronic myeloid leukemia

por Adattini, Josephine A., Gross, Annette S., Doo, Nicole Wong, McLachlan, Andrew J.
Publicado 2023

Real‐world efficacy and safety outcomes of imatinib treatment in patients with chronic myeloid leukemia: An Australian experience

por Adattini, Josephine A., Gross, Annette S., Wong Doo, Nicole, McLachlan, Andrew J.
Publicado 2022

A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity

por Duong, Janna K., Nand, Romina A., Patel, Aarti, Della Pasqua, Oscar, Gross, Annette S.
Publicado 2022

Ethnic sensitivity assessment of fluticasone furoate/vilanterol in East Asian asthma patients from randomized double-blind multicentre Phase IIb/III trials

por Gross, Annette S., Goldfrad, Caroline, Hozawa, Soichiro, James, Mark H., Clifton, Christine S., Sugiyama, Yutaro, Jacques, Loretta
Publicado 2015

Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A(2) Enzyme Inhibitor Darapladib in Healthy Chinese Subject...

por Hu, Chaoying, Tompson, Debra, Magee, Mindy, Chen, Qian, Liu, Yan Mei, Zhu, Wenjing, Zhao, Hongxin, Gross, Annette S., Liu, Yun
Publicado 2015

Pharmacokinetics and Tolerability of Inhaled Umeclidinium and Vilanterol Alone and in Combination in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Trial

por Hu, Chaoying, Jia, Jingying, Dong, Kelly, Luo, Linda, Wu, Kai, Mehta, Rashmi, Peng, Jack, Ren, Yan, Gross, Annette, Yu, Hui
Publicado 2015

The IMPACT Study – Single Inhaler Triple Therapy (FF/UMEC/VI) Versus FF/VI And UMEC/VI In Patients With COPD: Efficacy And Safety In A Japanese Population

por Kato, Motokazu, Tomii, Keisuke, Hashimoto, Kenichi, Nezu, Yasuko, Ishii, Takeo, Jones, C Elaine, Kilbride, Sally, Gross, Annette S, Clifton, Christine S, Lipson, David A
Publicado 2019

Pharmacokinetic, Safety, and Tolerability Evaluations of Gepotidacin (GSK2140944) in Healthy Japanese Participants

por Barth, Aline, Hossain, Mohammad, Perry, Caroline R., Gross, Annette S., Ogura, Hirofumi, Shabbir, Shaila, Thomas, Sebin, Dumont, Etienne F., Brimhall, Darin B., Srinivasan, Meenakshi, Swift, Brandon
Publicado 2022

Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects

por Tompson, Debra J., Davies, Carwyn, Scott, Nicola E., Cannons, Edward P., Kostapanos, Michalis, Gross, Annette S., Powell, Marcy, Ino, Hiroko, Shimamura, Ryutaro, Ogura, Hirofumi, Nagakubo, Takashi, Igarashi, Harue, Nakano, Atsushi
Publicado 2020

Characterization of ADME gene variation in 21 populations by exome sequencing

por Hovelson, Daniel H., Xue, Zhengyu, Zawistowski, Matthew, Ehm, Margaret G., Harris, Elizabeth C., Stocker, Sophie L., Gross, Annette S., Jang, In-Jin, Ieiri, Ichiro, Lee, Jong-Eun, Cardon, Lon R., Chissoe, Stephanie L., Abecasis, Gonçalo, Nelson, Matthew R.
Publicado 2017

Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation

por Sherpa, Dawafuti, Mueller, Judith, Karayel, Özge, Xu, Peng, Yao, Yu, Chrustowicz, Jakub, Gottemukkala, Karthik V, Baumann, Christine, Gross, Annette, Czarnecki, Oliver, Zhang, Wei, Gu, Jun, Nilvebrant, Johan, Sidhu, Sachdev S, Murray, Peter J, Mann, Matthias, Weiss, Mitchell J, Schulman, Brenda A, Alpi, Arno F
Publicado 2022

The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations

por da Rocha, Jorge E. B., Othman, Houcemeddine, Botha, Gerrit, Cottino, Laura, Twesigomwe, David, Ahmed, Samah, Drögemöller, Britt I., Fadlelmola, Faisal M., Machanick, Philip, Mbiyavanga, Mamana, Panji, Sumir, Wright, Galen E. B., Adebamowo, Clement, Matshaba, Mogomotsi, Ramsay, Michéle, Simo, Gustave, Simuunza, Martin C., Tiemessen, Caroline T., Baldwin, Sandra, Chiano, Mathias, Cox, Charles, Gross, Annette S., Thomas, Pamela, Gamo, Francisco-Javier, Hazelhurst, Scott
Publicado 2021

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

por Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J., Latomanski, Eleanor A., Newton, Hayley J., Guérillot, Romain J. R., Hachani, Abderrahman, Stinear, Timothy P., Ong, Sze Ying, Chandran, Yogeswari, Hartland, Elizabeth L., Kobe, Bostjan, Stow, Jennifer L., Sauer-Eriksson, A. Elisabeth, Begun, Jakob, Kling, Jessica C., Blumenthal, Antje
Publicado 2022