Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

por Holler, Marina, Grottke, Astrid, Mueck, Katharina, Manes, Julia, Jücker, Manfred, Rodemann, H. Peter, Toulany, Mahmoud
Publicado 2016

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

por Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T., Nashan, Björn, Jücker, Manfred
Publicado 2015

Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells

por Toulany, Mahmoud, Maier, Julia, Iida, Mari, Rebholz, Simone, Holler, Marina, Grottke, Astrid, Jüker, Manfred, Wheeler, Deric L, Rothbauer, Ulrich, Rodemann, H Peter
Publicado 2017

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

por Grottke, Astrid, Ewald, Florian, Lange, Tobias, Nörz, Dominik, Herzberger, Christiane, Bach, Johanna, Grabinski, Nicole, Gräser, Lareen, Höppner, Frank, Nashan, Björn, Schumacher, Udo, Jücker, Manfred
Publicado 2016

PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

por Hohensee, Ina, Chuang, Han-Ning, Grottke, Astrid, Werner, Stefan, Schulte, Alexander, Horn, Stefan, Lamszus, Katrin, Bartkowiak, Kai, Witzel, Isabell, Westphal, Manfred, Matschke, Jakob, Glatzel, Markus, Jücker, Manfred, Pukrop, Tobias, Pantel, Klaus, Wikman, Harriet
Publicado 2016

Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

por Kempska, Joanna, Oliveira-Ferrer, Leticia, Grottke, Astrid, Qi, Minyue, Alawi, Malik, Meyer, Felix, Borgmann, Kerstin, Hamester, Fabienne, Eylmann, Kathrin, Rossberg, Maila, Smit, Daniel J., Jücker, Manfred, Laakmann, Elena, Witzel, Isabell, Schmalfeldt, Barbara, Müller, Volkmar, Legler, Karen
Publicado 2023