A randomized, single ascending dose study of intravenous BIIB092 in healthy participants

por Qureshi, Irfan A., Tirucherai, Giridhar, Ahlijanian, Michael K., Kolaitis, Gerry, Bechtold, Clifford, Grundman, Michael
Publicado 2018

Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases

por Lizama, Britney N., Kahle, Jennifer, Catalano, Susan M., Caggiano, Anthony O., Grundman, Michael, Hamby, Mary E.
Publicado 2023

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

por Vellas, Bruno, Black, R, Thal, Leon J, Fox, Nick C, Daniels, M, McLennan, G, Tompkins, C, Leibman, C, Pomfret, M, Grundman, Michael
Publicado 2009

First‐in‐human assessment of PRX002, an anti–α‐synuclein monoclonal antibody, in healthy volunteers

por Schenk, Dale B., Koller, Martin, Ness, Daniel K., Griffith, Sue G., Grundman, Michael, Zago, Wagner, Soto, Jay, Atiee, George, Ostrowitzki, Susanne, Kinney, Gene G.
Publicado 2016

Real-World Treatment Patterns and Characteristics Among Patients with Agitation and Dementia in the United States: Findings from a Large, Observational, Retrospective Chart Review

por Aigbogun, Myrlene Sanon, Cloutier, Martin, Gauthier-Loiselle, Marjolaine, Guerin, Annie, Ladouceur, Martin, Baker, Ross A., Grundman, Michael, Duffy, Ruth A., Hartry, Ann, Gwin, Keva, Fillit, Howard
Publicado 2020

A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease

por Grundman, Michael, Morgan, Roger, Lickliter, Jason D., Schneider, Lon S., DeKosky, Steven, Izzo, Nicholas J., Guttendorf, Robert, Higgin, Michelle, Pribyl, Julie, Mozzoni, Kelsie, Safferstein, Hank, Catalano, Susan M.
Publicado 2019

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease

por Faridar, Alireza, Eid, Abdulmunaim M., Thome, Aaron D., Zhao, Weihua, Beers, David R., Pascual, Maria B., Nakawah, Mohammad O., Roman, Gustavo C., Davis, Charles S., Grundman, Michael, Masdeu, Joseph C., Appel, Stanley H.
Publicado 2023

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

por Colom-Cadena, Martí, Spires-Jones, Tara, Zetterberg, Henrik, Blennow, Kaj, Caggiano, Anthony, DeKosky, Steven T., Fillit, Howard, Harrison, John E., Schneider, Lon S., Scheltens, Phillip, de Haan, Willem, Grundman, Michael, van Dyck, Christopher H., Izzo, Nicholas J., Catalano, Susan M.
Publicado 2020

Evaluation of smartphone‐based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial

por Lipsmeier, Florian, Taylor, Kirsten I., Kilchenmann, Timothy, Wolf, Detlef, Scotland, Alf, Schjodt‐Eriksen, Jens, Cheng, Wei‐Yi, Fernandez‐Garcia, Ignacio, Siebourg‐Polster, Juliane, Jin, Liping, Soto, Jay, Verselis, Lynne, Boess, Frank, Koller, Martin, Grundman, Michael, Monsch, Andreas U., Postuma, Ronald B., Ghosh, Anirvan, Kremer, Thomas, Czech, Christian, Gossens, Christian, Lindemann, Michael
Publicado 2018

A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

por LaBarbera, Kelsie M., Sheline, Yvette I., Izzo, Nicholas J., Yuede, Carla M., Waybright, Lora, Yurko, Raymond, Edwards, Hannah M., Gardiner, Woodrow D., Blennow, Kaj, Zetterberg, Henrik, Börjesson-Hanson, Anne, Morgan, Roger, Davis, Charles S., Guttendorf, Robert J., Schneider, Lon S., DeKosky, Steven, LeVine, Harry, Grundman, Michael, Caggiano, Anthony O., Cirrito, John R., Catalano, Susan M., Hamby, Mary E.
Publicado 2023

Value-Generating Exploratory Trials in Neurodegenerative Dementias

por Friedman, Lauren G., McKeehan, Nicholas, Hara, Yuko, Cummings, Jeffrey L., Matthews, Dawn C., Zhu, Jian, Mohs, Richard C., Wang, Deli, Hendrix, Suzanne B., Quintana, Melanie, Schneider, Lon S., Grundman, Michael, Dickson, Samuel P., Feldman, Howard H., Jaeger, Judith, Finger, Elizabeth C., Ryan, J. Michael, Niehoff, Debra, Dickinson, Susan L-J., Markowitz, Jessica T., Owen, Meriel, Travaglia, Alessio, Fillit, Howard M.
Publicado 2021

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

por Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.
Publicado 2021