Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations

por Chen, Chao, Guan, Min-Xin
Publicado 2023

A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation

por Chen, Chao, Chen, Ye, Guan, Min-Xin
Publicado 2015

Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity

por Gao, Zewen, Chen, Ye, Guan, Min-Xin
Publicado 2017

Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

por Chen, Jing, Riazifar, Hamidreza, Guan, Min-Xin, Huang, Taosheng
Publicado 2016

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

por Li, Qianqian, Gao, Zewen, Chen, Ye, Guan, Min-Xin
Publicado 2017

Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

por Yao, Shihao, Ma, Boyuan, Yi, Qiuzi, Guan, Min-Xin, Cang, Xiaohui
Publicado 2022

Frequency and spectrum of MT-TT variants associated with Leber’s hereditary optic neuropathy in a Chinese cohort of subjects

por Lyu, Yuanyuan, Xu, Man, Chen, Jie, Ji, YanChun, Guan, Min-Xin, Zhang, Juanjuan
Publicado 2019

Species identification through mitochondrial rRNA genetic analysis

por Yang, Li, Tan, Zongqing, Wang, Daren, Xue, Ling, Guan, Min-xin, Huang, Taosheng, Li, Ronghua
Publicado 2014

Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier

por Yao, Shihao, Yi, Qiuzi, Ma, Boyuan, Mao, Xiaoting, Chen, Ye, Guan, Min-Xin, Cang, Xiaohui
Publicado 2022

Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids

por Zhao, Xiaoxu, Han, Jiamin, Zhu, Ling, Xiao, Yun, Wang, Chenghui, Hong, Fang, Jiang, Pingping, Guan, Min-Xin
Publicado 2018

Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function

por Zhang, Qinghai, Zhang, Luwen, Chen, Danni, He, Xiao, Yao, Shihao, Zhang, Zengming, Chen, Ye, Guan, Min-Xin
Publicado 2018

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility

por Meng, Yanzi, Liu, Xiaoling, Ma, Kai, Zhang, Lili, Lu, Mao, Zhao, Minsu, Guan, Min‐Xin, Qin, Guijun
Publicado 2019

Tissue-specific expression atlas of murine mitochondrial tRNAs

por He, Qiufen, He, Xiao, Xiao, Yun, Zhao, Qiong, Ye, Zhenzhen, Cui, Limei, Chen, Ye, Guan, Min-Xin
Publicado 2021

FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

por Fan, Wenlu, Jin, Xiaoye, Xu, Man, Xi, Yongmei, Lu, Weiguo, Yang, Xiaohang, Guan, Min-Xin, Ge, Wanzhong
Publicado 2021

Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber’s hereditary optic neuropathy

por Nie, Zhipeng, Wang, Chenghui, Chen, Jiarong, Ji, Yanchun, Zhang, Hongxing, Zhao, Fuxin, Zhou, Xiangtian, Guan, Min-Xin
Publicado 2022

Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

por Wang, Jing, Ji, Yanchun, Ai, Cheng, Chen, Jia-Rong, Gan, Dingyi, Zhang, Juanjuan, Mo, Jun Q., Guan, Min-Xin
Publicado 2023

A coronary artery disease-associated tRNA(Thr) mutation altered mitochondrial function, apoptosis and angiogenesis

por Jia, Zidong, Zhang, Ye, Li, Qiang, Ye, Zhenzhen, Liu, Yuqi, Fu, Changzhu, Cang, Xiaohui, Wang, Meng, Guan, Min-Xin
Publicado 2019

GJB2 Mutation Spectrum and Genotype-Phenotype Correlation in 1067 Han Chinese Subjects with Non-Syndromic Hearing Loss

por Zheng, Jing, Ying, Zhengbiao, Cai, Zhaoyang, Sun, Dongmei, He, Zheyun, Gao, Yinglong, Zhang, Ting, Zhu, Yi, Chen, Ye, Guan, Min-Xin
Publicado 2015

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism

por Chen, Danni, Zhang, Zengming, Chen, Chao, Yao, Shihao, Yang, Qingxian, Li, Feng, He, Xiao, Ai, Cheng, Wang, Meng, Guan, Min-Xin
Publicado 2019

Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts

por Xiao, Yun, Wang, Meng, He, Qiufen, Xu, Lei, Zhang, Qinghai, Meng, Feilong, Jia, Zidong, Zhang, Fengguo, Wang, Haibo, Guan, Min-Xin
Publicado 2020