Sirtuins, aging and diseases

por Guarente, Leonard
Publicado 2012

Calorie restriction and sirtuins revisited

por Guarente, Leonard
Publicado 2013

SIR2 Proteins Regulate Aging in Response to Nutrients

por Guarente, Leonard
Publicado 2001

Urea cycle regulation by mitochondrial sirtuin, SIRT5

por Nakagawa, Takashi, Guarente, Leonard
Publicado 2009

Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast

por Lin, Su-Ju, Guarente, Leonard
Publicado 2006

Sirtuin deacetylases in neurodegenerative diseases of aging

por Herskovits, Adrianna Z, Guarente, Leonard
Publicado 2013

It takes two to tango: NAD(+) and sirtuins in aging/longevity control

por Imai, Shin-ichiro, Guarente, Leonard
Publicado 2016

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

por Zainabadi, Kayvan, Liu, Cassie J., Guarente, Leonard
Publicado 2017

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo

por Bobrowska, Anna, Donmez, Gizem, Weiss, Andreas, Guarente, Leonard, Bates, Gillian
Publicado 2012

Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington’s Disease Phenotypes In Vivo

por Bobrowska, Anna, Donmez, Gizem, Weiss, Andreas, Guarente, Leonard, Bates, Gillian
Publicado 2021

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

por Chalkiadaki, Angeliki, Igarashi, Masaki, Nasamu, Armiyaw Sebastian, Knezevic, Jovana, Guarente, Leonard
Publicado 2014

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

por Zainabadi, Kayvan, Liu, Cassie J., Caldwell, Alison L. M., Guarente, Leonard
Publicado 2017

NAD(+) supplementation rejuvenates aged gut adult stem cells

por Igarashi, Masaki, Miura, Masaomi, Williams, Eric, Jaksch, Frank, Kadowaki, Takashi, Yamauchi, Toshimasa, Guarente, Leonard
Publicado 2019

Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

por Cunha-Santos, Janete, Duarte-Neves, Joana, Carmona, Vitor, Guarente, Leonard, Pereira de Almeida, Luís, Cavadas, Cláudia
Publicado 2016

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

por Dellinger, Ryan W., Santos, Santiago Roel, Morris, Mark, Evans, Mal, Alminana, Dan, Guarente, Leonard, Marcotulli, Eric
Publicado 2017

Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controll...

por Dellinger, Ryan W., Santos, Santiago Roel, Morris, Mark, Evans, Mal, Alminana, Dan, Guarente, Leonard, Marcotulli, Eric
Publicado 2018

Nicotinamide riboside with pterostilbene (NRPT) increases NAD(+) in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study o...

por Simic, Petra, Vela Parada, Xavier Fernando, Parikh, Samir M., Dellinger, Ryan, Guarente, Leonard P., Rhee, Eugene P.
Publicado 2020

SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis

por Herskovits, Adrianna Z., Hunter, Tegan A., Maxwell, Nicholas, Pereira, Katherine, Whittaker, Charles A., Valdez, Gregorio, Guarente, Leonard P.
Publicado 2018

4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations

por Tominaga, Kana, Tominaga, Naoomi, Williams, Eric O., Rufibach, Laura, Schöwel, Verena, Spuler, Simone, Viswanathan, Mohan, Guarente, Leonard P.
Publicado 2021

Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

por Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P
Publicado 2019