Data Mining and Machine Learning Models for Predicting Drug Likeness and Their Disease or Organ Category

por Yosipof, Abraham, Guedes, Rita C., García-Sosa, Alfonso T.
Publicado 2018

Computational Modulation of the V3 Region of Glycoprotein gp125 of HIV-2

por Serra, Patrícia A., Taveira, Nuno, Guedes, Rita C.
Publicado 2021

Synthesis of Computationally Designed 2,5(6)-Benzimidazole Derivatives via Pd-Catalyzed Reactions for Potential E. coli DNA Gyrase B Inhibition

por Aroso, Rafael T., Guedes, Rita C., Pereira, Mariette M.
Publicado 2021

Exploring the Chemical Space of Urease Inhibitors to Extract Meaningful Trends and Drivers of Activity

por Aniceto, Natália, Bonifácio, Vasco D. B., Guedes, Rita C., Martinho, Nuno
Publicado 2022

Recovering Actives in Multi-Antitarget and Target Design of Analogs of the Myosin II Inhibitor Blebbistatin

por Roman, Bart I., Guedes, Rita C., Stevens, Christian V., García-Sosa, Alfonso T.
Publicado 2018

Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview

por Guedes, Romina A., Serra, Patrícia, Salvador, Jorge A. R., Guedes, Rita C.
Publicado 2016

Using Machine Learning and Molecular Docking to Leverage Urease Inhibition Data for Virtual Screening

por Aniceto, Natália, Albuquerque, Tânia S., Bonifácio, Vasco D. B., Guedes, Rita C., Martinho, Nuno
Publicado 2023

Exploring EZH2-Proteasome Dual-Targeting Drug Discovery through a Computational Strategy to Fight Multiple Myeloma

por Estrada, Filipe G. A., Miccoli, Silvia, Aniceto, Natália, García-Sosa, Alfonso T., Guedes, Rita C.
Publicado 2021

Diazaborines as New Inhibitors of Human Neutrophil Elastase

por António, João P. M., Gonçalves, Lídia M., Guedes, Rita C., Moreira, Rui, Gois, Pedro M. P.
Publicado 2018

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design

por Guedes, Romina A., Aniceto, Natália, Andrade, Marina A. P., Salvador, Jorge A. R., Guedes, Rita C.
Publicado 2019

Multi-Targeting Approach in Glioblastoma Using Computer-Assisted Drug Discovery Tools to Overcome the Blood–Brain Barrier and Target EGFR/PI3Kp110β Signaling

por Franco, Catarina, Kausar, Samina, Silva, Margarida F. B., Guedes, Rita C., Falcao, Andre O., Brito, Maria Alexandra
Publicado 2022

Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors

por Aniceto, Natália, Marques, Vanda, Amaral, Joana D., Serra, Patrícia A., Moreira, Rui, Rodrigues, Cecília M. P., Guedes, Rita C.
Publicado 2022

Influence of dual task and frailty on gait parameters of older community-dwelling individuals

por Guedes, Rita C., Dias, Rosângela C., Pereira, Leani S. M., Silva, Sílvia L. A., Lustosa, Lygia P., Dias, João M. D.
Publicado 2014

An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles

por Rocha, Sónia, Aniceto, Natália, Guedes, Rita C., Albuquerque, Hélio M. T., Silva, Vera L. M., Silva, Artur M. S., Corvo, Maria Luísa, Fernandes, Eduarda, Freitas, Marisa
Publicado 2022

Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models

por Proença, Susana, Antunes, Bernardo, Guedes, Rita C., Ramilo-Gomes, Filipa, Cabral, M. Fátima, Costa, Judite, Fernandes, Ana S., Castro, Matilde, Oliveira, Nuno G., Miranda, Joana P.
Publicado 2019

Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance

por Leonardo-Sousa, Carlota, Carvalho, Andreia Neves, Guedes, Romina A., Fernandes, Pedro M. P., Aniceto, Natália, Salvador, Jorge A. R., Gama, Maria João, Guedes, Rita C.
Publicado 2022

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation

por Oliveira, Sara R., Dionísio, Pedro A., Brito, Hugo, Franco, Lídia, Rodrigues, Catarina A. B., Guedes, Rita C., Afonso, Carlos A. M., Amaral, Joana D., Rodrigues, Cecília M. P.
Publicado 2018

Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action

por Alves, Celso, Silva, Joana, Pintéus, Susete, Guedes, Romina A., Guedes, Rita C., Alvariño, Rebeca, Freitas, Rafaela, Goettert, Márcia I., Gaspar, Helena, Alfonso, Amparo, Alpoím, Maria C., Botana, Luis M., Pedrosa, Rui
Publicado 2022

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

por Brito, Hugo, Marques, Vanda, Afonso, Marta B., Brown, Dean G., Börjesson, Ulf, Selmi, Nidhal, Smith, David M., Roberts, Ieuan O., Fitzek, Martina, Aniceto, Natália, Guedes, Rita C., Moreira, Rui, Rodrigues, Cecília M. P.
Publicado 2020

Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response

por Pais, Teresa F., Ali, Hajrabibi, Moreira da Silva, Joana, Duarte, Nádia, Neres, Rita, Chhatbar, Chintan, Acúrcio, Rita C., Guedes, Rita C., Strano Moraes, Maria Carolina, Costa-Silva, Bruno, Kalinke, Ulrich, Penha-Gonçalves, Carlos
Publicado 2022