Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function

por Guenaga, Javier, Wyatt, Richard T.
Publicado 2012

Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

por Guenaga, Javier, de Val, Natalia, Tran, Karen, Feng, Yu, Satchwell, Karen, Ward, Andrew B., Wyatt, Richard T.
Publicado 2015

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

por Landeras-Bueno, Sara, Oda, Shun-ichiro, Norris, Michael J., Li Salie, Zhe, Guenaga, Javier, Wyatt, Richard T., Saphire, Erica Ollmann
Publicado 2019

Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

por Guenaga, Javier, Dosenovic, Pia, Ofek, Gilad, Baker, David, Schief, William R., Kwong, Peter D., Karlsson Hedestam, Gunilla B., Wyatt, Richard T.
Publicado 2011

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

por Dubrovskaya, Viktoriya, Guenaga, Javier, de Val, Natalia, Wilson, Richard, Feng, Yu, Movsesyan, Arlette, Karlsson Hedestam, Gunilla B., Ward, Andrew B., Wyatt, Richard T.
Publicado 2017

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

por Soldemo, Martina, Àdori, Monika, Stark, Julian M., Feng, Yu, Tran, Karen, Wilson, Richard, Yang, Lifei, Guenaga, Javier, Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Publicado 2017

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

por Yang, Lifei, Sharma, Shailendra Kumar, Cottrell, Christopher, Guenaga, Javier, Tran, Karen, Wilson, Richard, Behrens, Anna-Janina, Crispin, Max, de Val, Natalia, Wyatt, Richard T.
Publicado 2018

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

por Guenaga, Javier, Garces, Fernando, de Val, Natalia, Stanfield, Robyn L., Dubrovskaya, Viktoriya, Higgins, Brett, Carrette, Barbara, Ward, Andrew B., Wilson, Ian A., Wyatt, Richard T.
Publicado 2017

Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

por Feng, Yu, Tran, Karen, Bale, Shridhar, Kumar, Shailendra, Guenaga, Javier, Wilson, Richard, de Val, Natalia, Arendt, Heather, DeStefano, Joanne, Ward, Andrew B., Wyatt, Richard T.
Publicado 2016

HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization

por Navis, Marjon, Tran, Karen, Bale, Shridhar, Phad, Ganesh E., Guenaga, Javier, Wilson, Richard, Soldemo, Martina, McKee, Krisha, Sundling, Christopher, Mascola, John, Li, Yuxing, Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Publicado 2014

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

por Bale, Shridhar, Yang, Lifei, Alirezaei, Mehrdad, Wilson, Richard, Ota, Takayuki, Doyle, Esmeralda D., Cottrell, Christopher A., Guenaga, Javier, Tran, Karen, Li, Wenjuan, Stamatatos, Leonidas, Nemazee, David, Ward, Andrew B., Wyatt, Richard T.
Publicado 2023

Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41

por Zhang, Mei-Yun, Yuan, Tingting, Li, Jingjing, Rosa Borges, Andrew, Watkins, Jennifer D., Guenaga, Javier, Yang, Zheng, Wang, Yanping, Wilson, Richard, Li, Yuxing, Polonis, Victoria R., Pincus, Seth H., Ruprecht, Ruth M., Dimitrov, Dimiter S.
Publicado 2012

HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

por Dai, Kaifan, Khan, Salar N, Wang, Yimeng, He, Linling, Guenaga, Javier, Ingale, Jidnyasa, Sundling, Christopher, O’Dell, Sijy, McKee, Krisha, Phad, Ganesh, Corcoran, Martin, Wilson, Richard, Mascola, John R, Zhu, Jiang, Li, Yuxing, Hedestam, Gunilla B Karlsson, Wyatt, Richard T
Publicado 2016

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

por Steinhardt, James J., Guenaga, Javier, Turner, Hannah L., McKee, Krisha, Louder, Mark K., O’Dell, Sijy, Chiang, Chi-I, Lei, Lin, Galkin, Andrey, Andrianov, Alexander K., A. Doria-Rose, Nicole, Bailer, Robert T., Ward, Andrew B., Mascola, John R., Li, Yuxing
Publicado 2018

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

por Parks, K. Rachael, MacCamy, Anna J., Trichka, Josephine, Gray, Matthew, Weidle, Connor, Borst, Andrew J., Khechaduri, Arineh, Takushi, Brittany, Agrawal, Parul, Guenaga, Javier, Wyatt, Richard T., Coler, Rhea, Seaman, Michael, LaBranche, Celia, Montefiori, David C., Veesler, David, Pancera, Marie, McGuire, Andrew, Stamatatos, Leonidas
Publicado 2019

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

por Cao, Liwei, Pauthner, Matthias, Andrabi, Raiees, Rantalainen, Kimmo, Berndsen, Zachary, Diedrich, Jolene K., Menis, Sergey, Sok, Devin, Bastidas, Raiza, Park, Sung-Kyu Robin, Delahunty, Claire M., He, Lin, Guenaga, Javier, Wyatt, Richard T., Schief, William R., Ward, Andrew B., Yates, John R., Burton, Dennis R., Paulson, James C.
Publicado 2018

Global site-specific N-glycosylation analysis of HIV envelope glycoprotein

por Cao, Liwei, Diedrich, Jolene K., Kulp, Daniel W., Pauthner, Matthias, He, Lin, Park, Sung-Kyu Robin, Sok, Devin, Su, Ching Yao, Delahunty, Claire M., Menis, Sergey, Andrabi, Raiees, Guenaga, Javier, Georgeson, Erik, Kubitz, Michael, Adachi, Yumiko, Burton, Dennis R., Schief, William R., Yates III, John R., Paulson, James C.
Publicado 2017

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

por Dubrovskaya, Viktoriya, Tran, Karen, Ozorowski, Gabriel, Guenaga, Javier, Wilson, Richard, Bale, Shridhar, Cottrell, Christopher A., Turner, Hannah L., Seabright, Gemma, O’Dell, Sijy, Torres, Jonathan L., Yang, Lifei, Feng, Yu, Leaman, Daniel P., Vázquez Bernat, Néstor, Liban, Tyler, Louder, Mark, McKee, Krisha, Bailer, Robert T., Movsesyan, Arlette, Doria-Rose, Nicole A., Pancera, Marie, Karlsson Hedestam, Gunilla B., Zwick, Michael B., Crispin, Max, Mascola, John R., Ward, Andrew B., Wyatt, Richard T.
Publicado 2019

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

por Pauthner, Matthias, Havenar-Daughton, Colin, Sok, Devin, Nkolola, Joseph P., Bastidas, Raiza, Boopathy, Archana V., Carnathan, Diane G., Chandrashekar, Abishek, Cirelli, Kimberly M., Cottrell, Christopher A., Eroshkin, Alexey M., Guenaga, Javier, Kaushik, Kirti, Kulp, Daniel W., Liu, Jinyan, McCoy, Laura E., Oom, Aaron L., Ozorowski, Gabriel, Post, Kai W., Sharma, Shailendra K., Steichen, Jon M., de Taeye, Steven W., Tokatlian, Talar, Torrents de la Peña, Alba, Butera, Salvatore T., LaBranche, Celia C., Montefiori, David C., Silvestri, Guido, Wilson, Ian A., Irvine, Darrell J., Sanders, Rogier W., Schief, William R., Ward, Andrew B., Wyatt, Richard T., Barouch, Dan H., Crotty, Shane, Burton, Dennis R.
Publicado 2017