Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

por Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G
Publicado 2017

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

por Sullivan, Mark R, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Y, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G, Muir, Alexander
Publicado 2019

SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

por Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
Publicado 2015