A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

por Loeuillet, Corinne, Touquet, Bastien, Guichou, Jean François, Labesse, Gilles, Sereno, Denis
Publicado 2019

Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5

por Aguirre, Clémentine, Brink, Tim ten, Guichou, Jean-François, Cala, Olivier, Krimm, Isabelle
Publicado 2014

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA

por Eldin, Patrick, Chazal, Nathalie, Fenard, David, Bernard, Eric, Guichou, Jean-François, Briant, Laurence
Publicado 2014

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study

por Kaplan, Elise, Guichou, Jean-François, Chaloin, Laurent, Kunzelmann, Simone, Leban, Nadia, Serpersu, Engin H., Lionne, Corinne
Publicado 2016

Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention

por Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Brillet, Rozenn, Ahnou, Nazim, Hernandez, Eva, Pallier, Coralie, Pawlotsky, Jean-Michel
Publicado 2014

Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis

por Gorry, Rebecca L., Brennan, Kieran, Lavin, Paul T. M., Mazurski, Tayler, Mary, Charline, Matallanas, David, Guichou, Jean-François, Mc Gee, Margaret M.
Publicado 2023

A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice

por Jublot, Delphine, Cavaillès, Pierre, Kamche, Salima, Francisco, Denise, Fontinha, Diana, Prudêncio, Miguel, Guichou, Jean-Francois, Labesse, Gilles, Sereno, Denis, Loeuillet, Corinne
Publicado 2022

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity

por Sagnol, Sébastien, Yang, Yinshan, Bessin, Yannick, Allemand, Fréderic, Hapkova, Ilona, Notarnicola, Cécile, Guichou, Jean-François, Faure, Sandrine, Labesse, Gilles, de Santa Barbara, Pascal
Publicado 2014

The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia–reperfusion injury via mitoprotection

por Kheyar, Amel, Ahnou, Nazim, Ahmed-Belkacem, Abdelhakim, Hulin, Anne, Pressiat, Claire, Ghaleh, Bijan, Guichou, Jean-François, Morin, Didier, Pawlotsky, Jean-Michel, Teixeira-Clerc, Fatima
Publicado 2023

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

por Guca, Ewelina, Nagy, Gergely N., Hajdú, Fanni, Marton, Lívia, Izrael, Richard, Hoh, François, Yang, Yinshan, Vial, Henri, Vértessy, Beata G., Guichou, Jean-François, Cerdan, Rachel
Publicado 2018

Structural basis for chemically-induced homodimerization of a single domain antibody

por Lesne, Jean, Chang, Hung-Ju, De Visch, Angelique, Paloni, Matteo, Barthe, Philippe, Guichou, Jean-François, Mayonove, Pauline, Barducci, Alessandro, Labesse, Gilles, Bonnet, Jerome, Cohen-Gonsaud, Martin
Publicado 2019

Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity

por Van Bael, Jens, Vandenbulcke, Aline, Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Pawlotsky, Jean-Michel, Samyn, Jelle, Barendrecht, Arjan D., Maas, Coen, De Meyer, Simon F., Vanhoorelbeke, Karen, Tersteeg, Claudia
Publicado 2023

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

por Ahmed-Belkacem, Abdelhakim, Colliandre, Lionel, Ahnou, Nazim, Nevers, Quentin, Gelin, Muriel, Bessin, Yannick, Brillet, Rozenn, Cala, Olivier, Douguet, Dominique, Bourguet, William, Krimm, Isabelle, Pawlotsky, Jean-Michel, Guichou, Jean- François
Publicado 2016

Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity

por Nevers, Quentin, Ruiz, Isaac, Ahnou, Nazim, Donati, Flora, Brillet, Rozenn, Softic, Laurent, Chazal, Maxime, Jouvenet, Nolwenn, Fourati, Slim, Baudesson, Camille, Bruscella, Patrice, Gelin, Muriel, Guichou, Jean-François, Pawlotsky, Jean-Michel, Ahmed-Belkacem, Abdelhakim
Publicado 2018

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

por Lahaye, Xavier, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Silvin, Aymeric, Conrad, Cécile, Ahmed-Belkacem, Abdelhakim, Rodriguez, Elisa C., Guichou, Jean-François, Bosquet, Nathalie, Piel, Matthieu, Le Grand, Roger, King, Megan C., Pawlotsky, Jean-Michel, Manel, Nicolas
Publicado 2016

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

por Gibault, Floriane, Coevoet, Mathilde, Sturbaut, Manon, Farce, Amaury, Renault, Nicolas, Allemand, Frédéric, Guichou, Jean-François, Drucbert, Anne-Sophie, Foulon, Catherine, Magnez, Romain, Thuru, Xavier, Corvaisier, Matthieu, Huet, Guillemette, Chavatte, Philippe, Melnyk, Patricia, Bailly, Fabrice, Cotelle, Philippe
Publicado 2018

Proceedings of the Frontiers of Retrovirology Conference 2016

por Zurnic, Irena, Hütter, Sylvia, Lehmann, Ute, Stanke, Nicole, Reh, Juliane, Kern, Tobias, Lindel, Fabian, Gerresheim, Gesche, Hamann, Martin, Müllers, Erik, Lesbats, Paul, Cherepanov, Peter, Serrao, Erik, Engelman, Alan, Lindemann, Dirk, Da Silva Santos, Claire, Tartour, Kevin, Cimarelli, Andrea, Burdick, Rya, Chen, Jianbo, Sastri, Jaya, Hu, Wei-Shau, Pathak, Vinay, Keppler, Oliver T., Pradeau, Karine, Eiler, Sylvia, Levy, Nicolas, Lennon, Sarah, Cianferani, Sarah, Emiliani, Stéphane, Ruff, Marc, Parissi, Vincent, Rato, Sylvie, Rausell, Antonio, Munoz, Miguel, Telenti, Amalio, Ciuffi, Angela, Zhyvoloup, Alexander, Melamed, Anat, Anderson, Ian, Planas, Delphine, Kriston-Vizi, Janos, Ketteler, Robin, Lee, Chen- Hsuin, Merritt, Andy, Ancuta, Petronela, Bangham, Charles, Fassati, Ariberto, Rodari, Anthony, Van Driessche, Benoit, Galais, Mathilde, Delacourt, Nadége, Fauquenoy, Sylvain, Vanhulle, Caroline, Kula, Anna, Burny, Arsène, Rohr, Olivier, Van Lint, Carine, van Montfort, Thijs, van der Sluis, Renee, Speijer, Dave, Berkhout, Ben, Meng, Bo, Rutkowski, Andrzej, Berry, Neil, Dölken, Lars, Lever, Andrew, Schuster, Thomas, Asbach, Benedikt, Wagner, Ralf, Gross, Christine, Wiesmann, Veit, Kalmer, Martina, Wittenberg, Thomas, Gettemans, Jan, Thoma-Kress, Andrea K., Li, Minghua, Freed, Eric O., Liu, Shan-Lu, Müller, Janis, Münch, Jan, Sewald, Xaver, Uchil, Pradeep, Ladinsky, Mark, Beloor, Jagadish, Pi, Ruoxi, Herrmann, Christin, Motamedi, Nasim, Murooka, Thomas, Brehm, Michael, Greiner, Dale, Mempel, Thorsten, Bjorkman, Pamela, Kumar, Priti, Mothes, Walther, Joas, Simone, Parrish, Erica, Gnanadurai, Clement Wesley, Lump, Edina, Stürzel, Christina M., Parrish, Nicholas F., Sauermann, Ulrike, Töpfer, Katharina, Schultheiss, Tina, Bosinger, Steven, Silvestri, Guido, Apetrei, Cristian, Huot, Nicholas, Müller-Trutwin, Michaela, Sauter, Daniel, Hahn, Beatrice H., Stahl-Hennig, Christiane, Kirchhoff, Frank, Schumann, Gerald, Jung-Klawitter, Sabine, Fuchs, Nina V., Upton, Kyle R., Muñoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Gerdes, Patricia, Merkert, Sylvia, Pulgarin, Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltán, Izsvák, Zsuzsanna, Garcia-Perez, J., Faulkner, Geoffrey J., Hurst, Tara, Katzourakis, Aris, Magiorkinis, Gkikas, Schott, Kerstin, Derua, Rita, Seifried, Janna, Reuter, Andreas, Schmitz, Heike, Tondera, Christiane, Brandariz-Nuñez, Alberto, Diaz-Griffero, Felipe, Janssens, Veerle, König, Renate, Baldauf, Hanna-Mari, Stegmann, Lena, Schwarz, Sarah-Marie, Trotard, Maud, Martin, Margarethe, Lenzi, Gina, Burggraf, Manja, Pan, Xiaoyu, Fregoso, Oliver I., Lim, Efrem S., Abraham, Libin, Erikson, Elina, Nguyen, Laura, Ambiel, Ina, Rutsch, Frank, Kim, Baek, Emerman, Michael, Fackler, Oliver T., Wittmann, Sabine, Behrendt, Rayk, Volkmann, Bianca, Eissmann, Kristin, Gramberg, Thomas, Bolduan, Sebastian, Koppensteiner, Herwig, Regensburg, Stefanie, Brack-Werner, Ruth, Draenert, Rika, Schindler, Michael, Ducroux, Aurélie, Xu, Shuting, Ponnurangam, Aparna, Franz, Sergej, Malassa, Angelina, Ewald, Ellen, Goffinet, Christine, Fung, Sin-Yee, Chan, Ching-Ping, Yuen, Chun-Kit, Kok, Kin-Hang, Chan, Chin-Ping, Jin, Dong-Yan, Dittmer, Ulf, Kmiec, Dorota, Iyer, Shilpa, Stürzel, Christina, Hahn, Beatrice, Ariumi, Yasuo, Yasuda-Inoue, Mariko, Kawano, Koudai, Tateishi, Satoshi, Turelli, Priscilla, Compton, Alex, Roy, Nicolas, Porrot, Françoise, Billet, Anne, Casartelli, Nicoletta, Yount, Jacob, Liang, Chen, Schwartz, Oliver, Magnus, Carsten, Reh, Lucia, Moore, Penny, Uhr, Therese, Weber, Jacqueline, Morris, Lynn, Trkola, Alexandra, Grindberg, Rashel V., Schlaepfer, Erika, Schreiber, Gideon, Simon, Viviana, Speck, Roberto F., Debyser, Zeger, Vranckx, Lenard, Demeulemeester, Jonas, Saleh, Suha, Verdin, Eric, Cereseto, Anna, Christ, Frauke, Gijsbers, Rik, Wang, Gang, Zhao, Na, Das, Atze T., Köstler, Josef, Perdiguero, Beatriz, Esteban, Mariano, Jacobs, Bertram L., Montefiori, David C., LaBranche, Celia C., Yates, Nicole L., Tomaras, Georgia D., Ferrari, Guido, Foulds, Kathryn E., Roederer, Mario, Landucci, Gary, Forthal, Donald N., Seaman, Michael S., Hawkins, Natalie, Self, Steven G., Phogat, Sanjay, Tartaglia, James, Barnett, Susan W., Burke, Brian, Cristillo, Anthony D., Ding, Song, Heeney, Jonathan L., Pantaleo, Giuseppe, Stab, Viktoria, Ensser, Armin, Tippler, Bettina, Burton, Dennis, Tenbusch, Matthias, Überla, Klaus, Alter, Galit, Lofano, Giuseppe, Dugast, Anne-Sophie, Kulkarni, Viraj, Suscovich, Todd, Opazo, Tatiana, Barraza, Felipe, Herrera, Diego, Garces, Andrea, Schwenke, Tomas, Tapia, Diego, Cancino, Jorge, Arriagada, Gloria, Haußner, Christina, Damm, Dominik, Rohrhofer, Anette, Schmidt, Barbara, Eichler, Jutta, Midgley, Rebecca, Wheeldon, James, Piguet, Vincent, Khopkar, Priyanka, Rohamare, Megha, Kulkarni, Smita, Godinho-Santos, Ana, Hance, Allan, Goncalves, Joao, Mammano, Fabrizio, Gasser, Romain, Hamoudi, Meriem, Pellicciotta, Martina, Zhou, Zhicheng, Visdeloup, Clara, Colin, Philippe, Braibant, Martine, Lagane, Bernard, Negroni, Matteo, Wamara, Jula, Bannert, Norbert, Mesplede, Thibault, Osman, Nathan, Anstett, Kaitlin, Liang, Jiaming Calvin, Pham, Hanh Thi, Wainberg, Mark, Shao, Wei, Shan, Jigui, Kearney, Mary, Wu, Xiaolin, Maldarelli, Frank, Mellors, John, Luke, Brian, Coffin, John, Hughes, Stephen, Fricke, Thomas, Opp, Silvana, Shepard, Caitlin, Ivanov, Dmitri, Valle-Casuso, Jose, Kanja, Marine, Cappy, Pierre, Negroni, Matteo, Lener, Daniela, Knyazhanskaya, Ekaterina, Anisenko, Andrey, Zatsepin, Timofey, Gottikh, Marina, Komkov, Alexander, Minervina, Anastasia, Nugmanov, Gaiaz, Nazarov, Vadim, Khodosevich, Konstantin, Mamedov, Ilgar, Lebedev, Yuri, Colomer-Lluch, Marta, Serra-Moreno, Ruth, Sarracino, Ambra, Gharu, Lavina, Pasternak, Alexander, Marcello, Alessandro, McCartin, Ann Marie, Kulkarni, Anurag, Le Douce, Valentin, Gautier, Virginie, Baeyens, Ann, Naessens, Evelien, Van Nuffel, Anouk, Weening, Karin, Reilly, Anne- Marie, Claeys, Eva, Trypsteen, Wim, Vandekerckhove, Linos, Eyckerman, Sven, Gevaert, Kris, Verhasselt, Bruno, Mok, Hoi Ping, Norton, Nicholas, Fun, Axel, Hirst, Jack, Wills, Mark, Miklik, Dalibor, Senigl, Filip, Hejnar, Jiri, Sakuragi, Jun-ichi, Sakuragi, Sayuri, Yokoyama, Masaru, Shioda, Tatsuo, Sato, Hironori, Bodem, Jochen, Moschall, Rebecca, Denk, Sarah, Erkelenz, Steffen, Schenk, Christian, Schaal, Heiner, Donhauser, Norbert, Socher, Ellen, Millen, Sebastian, Sticht, Heinrich, Gross, Christine, Mann, Melanie, Wei, Guochao, Betts, Matthew J., Liu, Yang, Kehl, Timo, Russell, Robert B., Löchelt, Martin, Hohn, Oliver, Mostafa, Saeed, Hanke, Kirsten, Norley, Stephen, Chen, Chia-Yen, Shingai, Masashi, Borrego, Pedro, Taveira, Nuno, Strebel, Klaus, Hellmund, Chris, Meng, Bo, Friedrich, Melanie, Hahn, Friedrich, Setz, Christian, Rauch, Pia, Fraedrich, Kirsten, Matthaei, Alina, Henklein, Petra, Traxdorf, Maximilian, Fossen, Torgils, Schubert, Ulrich, Khwaja, Aya, Galilee, Meytal, Alian, Akram, Schwalbe, Birco, Hauser, Heiko, Schreiber, Michael, Scherpenisse, Mirte, Cho, Young-Keol, Kim, Jungeun, Jeong, Daeun, Trejbalova, Katerina, Benesova, Martina, Kucerova, Dana, Vernerova, Zdenka, Amouroux, Rachel, Hajkova, Petra, Elleder, Daniel, Hron, Tomas, Farkasova, Helena, Padhi, Abinash, Paces, Jan, Zhu, Henan, Gifford, Robert, Murcia, Pablo, Carrozza, Maria Luisa, Niewiadomska, Anna-Maria, Mazzei, Maurizio, Abi-Said, Mounir, Hughes, Joseph, Hué, Stéphane, Gifford, Robert, Obasa, Adetayo, Jacobs, Graeme, Engelbrecht, Susan, Mack, Katharina, Starz, Kathrin, Geyer, Matthias, Bibollet-Ruche, Frederic, Stürzel, Christina, Leoz, Marie, Plantier, Jean Christophe, Argaw-Denboba, Ayele, Balestrieri, Emanuela, Serafino, Annalucia, Bucci, Ilaria, Cipriani, Chiara, Spadafora, Corrado, Sinibaldi-Vallebona, Paolo, Matteucci, Claudia, Jayashree, S. Nandi, Neogi, Ujjwal, Chhangani, Anil K., Rathore, Shravan Sing, Mathur, Bajrang R. J., Abati, Adeyemi, Koç, B. Taylan, Oğuzoğlu, Tuba Çiğdem, Shimauchi, Takatoshi, Caucheteux, Stephan, Turpin, Jocelyn, Finsterbusch, Katja, Tokura, Yoshiki, Souriant, Shanti, Balboa, Luciana, Pingris, Karine, Kviatcowsky, Denise, Raynaud-Messina, Brigitte, Cougoule, Céline, Mercier, Ingrid, Kuroda, Marcelo, González-Montaner, Pablo, Inwentarz, Sandra, Moraña, Eduardo Jose, del Carmen Sasiain, Maria, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, Vérollet, Christel, Herrmann, Alexandra, Thomas, Dominique, Bouzas, Nerea Ferreirós, Lahaye, Xavier, Bhargava, Anvita, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Silvin, Aymeric, Conrad, Cécile, Ahmed-Belkacem, Hakim, Rodriguez, Elisa C., Guichou, Jean-François, Bosquet, Nathalie, Piel, Matthieu, Le Grand, Roger, King, Megan, Pawlotsky, Jean-Michel, Manel, Nicolas, Hofmann, Henning, Vanwalscappel, Benedicte, Bloch, Nicolin, Landau, Nathaniel, Indik, Stanislav, Hagen, Benedikt, Valle-Casuso, José Carlos, Allouch, Awatef, David, Annie, Barré-Sinoussi, Françoise, Benkirane, Monsef, Pancino, Gianfranco, Saez-Cirion, Asier, Lee, Wing-Yiu, Sloan, Richard, Schulte, Bianca, Opp, Silvana, Blomberg, Jonas, Vargiu, Luana, Rodriguez-Tomé, Patricia, Tramontano, Enzo, Sperber, Göran, Kumari, Namita, Ammosova, Tatiana, Diaz, Sharmeen, Oneal, Patricia, Nekhai, Sergei, Fahrny, Audrey, Gers-Huber, Gustavo, Audigé, Annette, Jayaprakash, Anitha, Sachidanandam, Ravi, Hernandez, Matt, Dillon-White, Marsha, Souriant, Shanti, Pingris, Karine, Raynaud-Messina, Brigitte, Cougoule, Céline, Mercier, Ingrid, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, Maze, Emmanuel, Ham, Claire, Almond, Neil, Towers, Greg, Belshaw, Robert, de Sousa-Pereira, Patrícia, Abrantes, Joana, Pizzato, Massimo, Esteves, Pedro J., Kahle, Tanja, Schmitt, Sven, Merkel, Laura, Reuter, Nina, Stamminger, Thomas, Rosa, Ilaria Dalla, Bishop, Kate, Spinazzola, Antonella, Groom, Harriet, Vieyres, Gabrielle, Müsken, Mathias, Zillinger, Thomas, Hornung, Veit, Barchet, Winfried, Häussler, Susanne, Pietschmann, Thomas, Javed, Aneela, Leuchte, Nicole, Salinas, Gabriela, Opitz, Lennart, Sopper, Sieghart, Mummert, Christiane, Hofmann, Christian, Hückelhoven, Angela G., Bergmann, Silke, Müller-Schmucker, Sandra M., Harrer, Ellen G., Dörrie, Jan, Schaft, Niels, Harrer, Thomas, Cardinaux, Laure, Zahno, M.- L., Vogt, H.- R., Zanoni, R., Bertoni, G., Muenchhoff, Maximilian, Goulder, Philip, Keppler, Oliver, Rebensburg, Stephanie, Helfer, Markus, Zhang, Yuwei, Chen, Huicheng, Bernier, Annie, Gosselin, Annie, Routy, Jean- Pierre, Wöhrl, Birgitta, Schneider, Anna, Corona, Angela, Spöring, Imke, Jordan, Mareike, Buchholz, Bernd, Maccioni, Elias, Di Santo, Roberto, Schweimer, Kristian, Schölz, Christian, Weinert, Brian, Wagner, Sebastian, Beli, Petra, Miyake, Yasuyuki, Qi, Jun, Jensen, Lars, Streicher, Werner, McCarthy, Anna, Westwood, Nicholas, Lain, Sonia, Cox, Jürgen, Matthias, Patrick, Mann, Matthias, Bradner, James, Choudhary, Chunaram, Stern, Marcel, Valletta, Elena, Frezza, Caterina, Marino-Merlo, Francesca, Grelli, Sandro, Serafino, Anna Lucia, Mastino, Antonio, Macchi, Beatrice, Kaulfuß, Meike, Windmann, Sonja, Bayer, Wibke, Mikasi, Sello, Jacobs, Graeme, Heß, Rebecca, Bonsmann, Michael Storcksdieck gen., Kirschning, Carsten, Lepenies, Bernd, Kolenbrander, Anne, Temchura, Vladimir, Iijima, Kenta, Kobayashi, Junya, Ishizaka, Yukihito
Publicado 2016