Cell senescence in neuropathology: A focus on neurodegeneration and tumours

por Carreno, Gabriela, Guiho, Romain, Martinez‐Barbera, Juan Pedro
Publicado 2021

HGG-07. RADIATION INDUCED SENESCENCE IN DIFFUSE INTRINSIC PONTINE GLIOMA CELLS REVEALS SELECTIVE VULNERABILITY TO BCL-XL INHIBITION

por Vardon, Ashley, Guiho, Romain, Carvalho, Diana, Jones, Chris, Hargrave, Darren, Martinez-Barbera, Juan-Pedro
Publicado 2021

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma

por Lamoureux, Francois, Baud'huin, Marc, Ory, Benjamin, Guiho, Romain, Zoubeidi, Amina, Gleave, Martin, Heymann, Dominique, Rédini, Françoise
Publicado 2014

TRAIL-Based Therapies Efficacy in Pediatric Bone Tumors Models Is Modulated by TRAIL Non-Apoptotic Pathway Activation via RIPK1 Recruitment

por Brion, Régis, Gantier, Malika, Biteau, Kevin, Taurelle, Julien, Brounais-Le Royer, Bénédicte, Verrecchia, Franck, Rédini, Françoise, Guiho, Romain
Publicado 2022

Galactose‐modified duocarmycin prodrugs as senolytics

por Guerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez‐Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús
Publicado 2020

LGG-09. SENOLYTIC AGENT NAVITOCLAX TARGETS VINBLASTINE- AND MAPK INHIBITORS-INDUCED SENESCENT TUMOUR CELLS IN PAEDIATRIC LOW GRADE GLIOMAS

por Guiho, Romain, Selt, Florian, Stone, Thomas, Jacques, Thomas, Hargrave, Darren, Gil, Jesús, Witt, Olaf, Milde, Till, Barbera, Juan Pedro Martinez
Publicado 2021

Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

por Georget, Mélina, Defois, Anaïs, Guiho, Romain, Bon, Nina, Allain, Sophie, Boyer, Cécile, Halgand, Boris, Waast, Denis, Grimandi, Gaël, Fouasson-Chailloux, Alban, Guicheux, Jérôme, Vinatier, Claire
Publicado 2023

DIPG-46. Radiation induced senescence in diffuse intrinsic pontine glioma cells reveals selective vulnerability to Bcl-XL inhibition

por Vardon, Ashley, Guiho, Romain, Carvalho, Diana, Boult, Jessica, Carter, Rebecca, Grabovska, Yura, Mackay, Alan, Zheng, Guangrong, Zhou, Daohong, Hiley, Crispin, Lythgoe, Mark, Jones, Chris, Hargrave, Darren, Martinez-, Juan-Pedro
Publicado 2022

LGG-17. Preventing recurrence: targeting molecular mechanisms driving tumor growth rebound after MAPKi withdrawal in pediatric low-grade glioma

por Kocher, Daniela, Selt, Florian, Valinciute, Gintvile, Zaman, Julia, Vonhören, David, Pusch, Stefan, Guiho, Romain, Martinez-Barbera, Juan Pedro, von Deimling, Andreas, Pfister, Stefan M, Jones, David T W, Brummer, Tilman, Witt, Olaf, Milde, Till, Sigaud, Romain
Publicado 2022

LGG-11. BH3-MIMETICS TARGETING BCL-XL SELECTIVELY IMPACT THE SENESCENT COMPARTMENT OF PILOCYTIC ASTROCYTOMA

por Selt, Florian, Sigaud, Romain, Sievers, Philipp, Zaman, Julia, Peterziel, Heike, Tsai, Jessica W, Guiho, Romain, Martínez-Barbera, Juan Pedro, Pusch, Stefan, Schuhmann, Martin U, El Damaty, Ahmed, Bandopadhayay, Pratiti, Pfister, Stefan M, Oehme, Ina, Sahm, Felix, Jones, David T W, Witt, Olaf, Milde, Till
Publicado 2021

Cardiac glycosides are broad-spectrum senolytics

por Guerrero, Ana, Herranz, Nicolás, Sun, Bin, Wagner, Verena, Gallage, Suchira, Guiho, Romain, Wolter, Katharina, Pombo, Joaquim, Irvine, Elaine E., Innes, Andrew J., Birch, Jodie, Glegola, Justyna, Manshaei, Saba, Heide, Danijela, Dharmalingam, Gopuraja, Harbig, Jule, Olona, Antoni, Behmoaras, Jacques, Dauch, Daniel, Uren, Anthony G., Zender, Lars, Vernia, Santiago, Martínez-Barbera, Juan Pedro, Heikenwalder, Mathias, Withers, Dominic J., Gil, Jesús
Publicado 2019

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pa...

por Apps, John R., Carreno, Gabriela, Gonzalez-Meljem, Jose Mario, Haston, Scott, Guiho, Romain, Cooper, Julie E., Manshaei, Saba, Jani, Nital, Hölsken, Annett, Pettorini, Benedetta, Beynon, Robert J., Simpson, Deborah M., Fraser, Helen C., Hong, Ying, Hallang, Shirleen, Stone, Thomas J., Virasami, Alex, Donson, Andrew M., Jones, David, Aquilina, Kristian, Spoudeas, Helen, Joshi, Abhijit R., Grundy, Richard, Storer, Lisa C. D., Korbonits, Márta, Hilton, David A., Tossell, Kyoko, Thavaraj, Selvam, Ungless, Mark A., Gil, Jesus, Buslei, Rolf, Hankinson, Todd, Hargrave, Darren, Goding, Colin, Andoniadou, Cynthia L., Brogan, Paul, Jacques, Thomas S., Williams, Hywel J., Martinez-Barbera, Juan Pedro
Publicado 2018