The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes

por Bahjat, Mahnoush, Guikema, Jeroen E. J.
Publicado 2017

Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences

por Stratigopoulou, Maria, van Dam, Tijmen P., Guikema, Jeroen E. J.
Publicado 2020

Metabolic Effects of Recurrent Genetic Aberrations in Multiple Myeloma

por Bloedjes, Timon A., de Wilde, Guus, Guikema, Jeroen E. J.
Publicado 2021

Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoires

por Pelissier, Aurelien, Luo, Siyuan, Stratigopoulou, Maria, Guikema, Jeroen E. J., Rodríguez Martínez, María
Publicado 2023

A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β

por Pei, De-Sheng, Yang, Xiao-Jie, Liu, Wei, Guikema, Jeroen E. J., Schrader, Carol E., Strauss, Phyllis R.
Publicado 2011

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

por Guikema, Jeroen E.J., Linehan, Erin K., Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Strauss, Phyllis R., Stavnezer, Janet, Schrader, Carol E.
Publicado 2007

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

por Guikema, Jeroen E.J., Linehan, Erin K., Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Strauss, Phyllis R., Stavnezer, Janet, Schrader, Carol E.
Publicado 2007

Convergent evolution and B-cell recirculation in germinal centers in a human lymph node

por Pelissier, Aurelien, Stratigopoulou, Maria, Donner, Naomi, Dimitriadis, Evangelos, Bende, Richard J, Guikema, Jeroen E, Rodriguez Martinez, Maria, van Noesel, Carel JM
Publicado 2023

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to...

por Merino Tejero, Elena, Lashgari, Danial, García-Valiente, Rodrigo, He, Jiaojiao, Robert, Philippe A., Meyer-Hermann, Michael, Guikema, Jeroen E. J., Hoefsloot, Huub, van Kampen, Antoine H. C.
Publicado 2021

Salivary Gland Mucosa‐Associated Lymphoid Tissue–Type Lymphoma From Sjögren’s Syndrome Patients in the Majority Express Rheumatoid Factors Affinity‐Selected for IgG

por Bende, Richard J., Janssen, Jerry, Beentjes, Anna, Wormhoudt, Thera A. M., Wagner, Koen, Haacke, Erlin A., Kroese, Frans G. M., Guikema, Jeroen E. J., van Noesel, Carel J. M.
Publicado 2020

Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation

por Thus, Yvonne J., de Rooij, Martin F.M., Swier, Nathalie, Beijersbergen, Roderick L., Guikema, Jeroen E.J., Kersten, Marie-José, Eldering, Eric, Pals, Steven T., Kater, Arnon P., Spaargaren, Marcel
Publicado 2022

Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing

por Reshetova, Polina, van Schaik, Barbera D. C., Klarenbeek, Paul L., Doorenspleet, Marieke E., Esveldt, Rebecca E. E., Tak, Paul-Peter, Guikema, Jeroen E. J., de Vries, Niek, van Kampen, Antoine H. C.
Publicado 2017

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

por Bahjat, Mahnoush, de Wilde, Guus, van Dam, Tijmen, Maas, Chiel, Bloedjes, Timon, Bende, Richard J., van Noesel, Carel J.M., Luijks, Dieuwertje M., Eldering, Eric, Kersten, Marie José, Guikema, Jeroen E.J.
Publicado 2019

A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi

por Hoogeboom, Robbert, van Kessel, Kok P.M., Hochstenbach, Frans, Wormhoudt, Thera A., Reinten, Roy J.A., Wagner, Koen, Kater, Arnon P., Guikema, Jeroen E.J., Bende, Richard J., van Noesel, Carel J.M.
Publicado 2013

AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity

por Bloedjes, Timon A., de Wilde, Guus, Khan, Gerarda H., Ashby, Timothy C., Shaughnessy, John D., Zhan, Fenghuang, Houtkooper, Riekelt H., Bende, Richard J., van Noesel, Carel J. M., Spaargaren, Marcel, Guikema, Jeroen E. J.
Publicado 2022

A Major Subset of Mutated CLL Expresses Affinity-selected and Functionally Proficient Rheumatoid Factors

por Janssen, Jerry, Donner, Naomi, Li, Zhen, Wormhoudt, Thera A.M., Wagner, Koen, Guikema, Jeroen E.J., van der Schoot, C. Ellen, Kater, Arnon P., Feizi, Ten, Bende, Richard J., van Noesel, Carel J.M.
Publicado 2021

Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Hel...

por Merino Tejero, Elena, Lashgari, Danial, García-Valiente, Rodrigo, Gao, Xuefeng, Crauste, Fabien, Robert, Philippe A., Meyer-Hermann, Michael, Martínez, María Rodríguez, van Ham, S. Marieke, Guikema, Jeroen E. J., Hoefsloot, Huub, van Kampen, Antoine H. C.
Publicado 2021

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

por Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz
Publicado 2023

Understanding repertoire sequencing data through a multiscale computational model of the germinal center

por García-Valiente, Rodrigo, Merino Tejero, Elena, Stratigopoulou, Maria, Balashova, Daria, Jongejan, Aldo, Lashgari, Danial, Pélissier, Aurélien, Caniels, Tom G., Claireaux, Mathieu A. F., Musters, Anne, van Gils, Marit J., Rodríguez Martínez, María, de Vries, Niek, Meyer-Hermann, Michael, Guikema, Jeroen E. J., Hoefsloot, Huub, van Kampen, Antoine H. C.
Publicado 2023

SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

por Leeksma, Alexander C., Derks, Ingrid A. M., Garrick, Brett, Jongejan, Aldo, Colombo, Martino, Bloedjes, Timon, Trowe, Torsten, Leisten, Jim C., Howarth, Michelle, Malek, Mehnaz, Mortensen, Deborah S., Blease, Kate, Groza, Mathew C., Narla, Rama Krishna, Loos, Remco, Kersten, Marie‐José, Moerland, Perry D., Guikema, Jeroen E. J., Kater, Arnon P., Eldering, Eric, Filvaroff, Ellen H.
Publicado 2022