Autophagy, Metabolism, and Cancer

por Guo, Jessie Yanxiang, White, Eileen
Publicado 2017

Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

por Khayati, Khoosheh, Bhatt, Vrushank, Hu, Zhixian Sherrie, Fahumy, Sajid, Luo, Xuefei, Guo, Jessie Yanxiang
Publicado 2020

Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells

por Mondal, Arindam, Jia, Dongxuan, Bhatt, Vrushank, Akel, Moumen, Roberge, Jacques, Guo, Jessie Yanxiang, Langenfeld, John
Publicado 2022

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

por Bhatt, Vrushank, Khayati, Khoosheh, Hu, Zhixian Sherrie, Lee, Amy, Kamran, Wali, Su, Xiaoyang, Guo, Jessie Yanxiang
Publicado 2019

Emi2-mediated Inhibition of E2-substrate Ubiquitin Transfer by the Anaphase-promoting Complex/Cyclosome through a D-Box–independent Mechanism

por Tang, Wanli, Wu, Judy Qiju, Chen, Chen, Yang, Chih-Sheng, Guo, Jessie Yanxiang, Freel, Christopher D., Kornbluth, Sally
Publicado 2010

Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1

por Qiu, Guihua, Liu, Jian, Cheng, Qianqian, Wang, Qingyang, Jing, Zhaofei, Pei, Yujun, Zhao, Min, Wang, Jing, Guo, Jessie Yanxiang, Zhang, Jiyan
Publicado 2017

CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer

por Jariwala, Nidhi, Mehta, Gaurav A, Bhatt, Vrushank, Hussein, Shaimaa, Parker, Kimberly A, Yunus, Neha, Parker, Joel S, Guo, Jessie Yanxiang, Gatza, Michael L
Publicado 2021

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

por Guo, Jessie Yanxiang, Teng, Xin, Laddha, Saurabh V., Ma, Sirui, Van Nostrand, Stephen C., Yang, Yang, Khor, Sinan, Chan, Chang S., Rabinowitz, Joshua D., White, Eileen
Publicado 2016

MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation

por Liu, Jia, Zhang, Qing, Ruan, Banlai, Chen, Wei, Zheng, Jianyu, Xu, Buxuan, Jiang, Peijia, Miao, Zhifeng, Li, Feng, Guo, Jessie Yanxiang, Cao, Liu, Wang, Guiling
Publicado 2019

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

por Liu, Yingying, Gokhale, Samantha, Jung, Jaeyong, Zhu, Sining, Luo, Chang, Saha, Debanjan, Guo, Jessie Yanxiang, Zhang, Huaye, Kyin, Saw, Zong, Wei-Xing, White, Eileen, Xie, Ping
Publicado 2021

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis

por Yue, Xuetian, Wang, Jianming, Chang, Chun-yuan, Liu, Juan, Yang, Xue, Zhou, Fan, Qiu, Xia, Bhatt, Vrushank, Guo, Jessie Yanxiang, Su, Xiaoyang, Zhang, Lanjing, Feng, Zhaohui, Hu, Wenwei
Publicado 2022

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration

por Huo, Yanying, Sawant, Akshada, Tan, Yongmei, Mahdi, Amar H, Li, Tao, Ma, Hui, Bhatt, Vrushank, Yan, Run, Coleman, Jake, Dreyfus, Cheryl F, Guo, Jessie Yanxiang, Mouradian, M. Maral, White, Eileen, Xia, Bing
Publicado 2022

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

por Lan, Taijin, Arastu, Sara, Wang, Samuel, Lam, Jarrick, Wang, Wenping, Bhatt, Vrushank, Lopes, Eduardo Cararo, Hu, Zhixian, Sun, Michael, Luo, Xuefei, Ghergurovich, Jonathan M., Li, Changlong, Su, Xiaoyang, Rabinowitz, Joshua D., White, Eileen, Guo, Jessie Yanxiang
Publicado 2023

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

por Dai, Weiwei, Shen, Jianliang, Yan, Junrong, Bott, Alex J., Maimouni, Sara, Daguplo, Heineken Q., Wang, Yujue, Khayati, Khoosheh, Guo, Jessie Yanxiang, Zhang, Lanjing, Wang, Yongbo, Valvezan, Alexander, Ding, Wen-Xing, Chen, Xin, Su, Xiaoyang, Gao, Shenglan, Zong, Wei-Xing
Publicado 2022

Autophagy maintains tumor growth through circulating arginine

por Poillet-Perez, Laura, Xie, Xiaoqi, Zhan, Le, Yang, Yang, Sharp, Daniel W., Hu, Zhixian Sherrie, Su, Xiaoyang, Maganti, Anurag, Jiang, Cherry, Lu, Wenyun, Zheng, Haiyan, Bosenberg, Marcus W., Mehnert, Janice M., Guo, Jessie Yanxiang, Lattime, Edmund, Rabinowitz, Joshua D., White, Eileen
Publicado 2018

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors

por Bhatt, Vrushank, Lan, Taijin, Wang, Wenping, Kong, Jerry, Lopes, Eduardo Cararo, Wang, Jianming, Khayati, Khoosheh, Raju, Akash, Rangel, Michael, Lopez, Enrique, Hu, Zhixian Sherrie, Luo, Xuefei, Su, Xiaoyang, Malhotra, Jyoti, Hu, Wenwei, Pine, Sharon R., White, Eileen, Guo, Jessie Yanxiang
Publicado 2023

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

por Feng, William W., Wilkins, Owen, Bang, Scott, Ung, Matthew, Li, Jiaqi, An, Jennifer, del Genio, Carmen, Canfield, Kaleigh, DiRenzo, James, Wells, Wendy, Gaur, Arti, Robey, R. Brooks, Guo, Jessie Yanxiang, Powles, Ryan L., Sotiriou, Christos, Pusztai, Lajos, Febbraio, Maria, Cheng, Chao, Kinlaw, William B., Kurokawa, Manabu
Publicado 2019

Integrated metabolic and genetic analysis reveals distinct features of primary differentiated thyroid cancer and its metastatic potential in humans

por Cararo-Lopes, Eduardo, Sawant, Akshada, Moore, Dirk, Ke, Hua, Shi, Fuqian, Laddha, Saurabh, Chen, Ying, Sharma, Anchal, Naumann, Jake, Guo, Jessie Yanxiang, Gomez, Maria, Ibrahim, Maria, Smith, Tracey L, Riedlinger, Gregory M., Lattime, Edmund C., Trooskin, Stanley, Ganesan, Shridar, Su, Xiaoyang, Pasqualini, Renata, Arap, Wadih, De, Subhajyoti, Chan, Chang S., White, Eileen
Publicado 2023

Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer

por Cararo Lopes, Eduardo, Sawant, Akshada, Moore, Dirk, Ke, Hua, Shi, Fuqian, Laddha, Saurabh, Chen, Ying, Sharma, Anchal, Naumann, Jake, Guo, Jessie Yanxiang, Gomez, Maria, Ibrahim, Maria, Smith, Tracey L., Riedlinger, Gregory M., Lattime, Edmund C., Trooskin, Stanley, Ganesan, Shridar, Su, Xiaoyang, Pasqualini, Renata, Arap, Wadih, De, Subhajyoti, Chan, Chang S., White, Eileen
Publicado 2023

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

por Bott, Alex J., Shen, Jianliang, Tonelli, Claudia, Zhan, Le, Sivaram, Nithya, Jiang, Ya-Ping, Yu, Xufen, Bhatt, Vrushank, Chiles, Eric, Zhong, Hua, Maimouni, Sara, Dai, Weiwei, Velasquez, Stephani, Pan, Ji-An, Muthalagu, Nathiya, Morton, Jennifer, Anthony, Tracy G., Feng, Hui, Lamers, Wouter H., Murphy, Daniel J., Guo, Jessie Yanxiang, Jin, Jian, Crawford, Howard C., Zhang, Lanjing, White, Eileen, Lin, Richard Z., Su, Xiaoyang, Tuveson, David A., Zong, Wei-Xing
Publicado 2019