Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

por Trunkfield, Amy E., Gurcha, Sudagar S., Besra, Gurdyal S., Bugg, Timothy D.H.
Publicado 2010

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

por Usha, Veeraraghavan, Hobrath, Judith V., Gurcha, Sudagar S., Reynolds, Robert C., Besra, Gurdyal S.
Publicado 2012

DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

por Abrahams, Katherine A., Batt, Sarah M., Gurcha, Sudagar S., Veerapen, Natacha, Bashiri, Ghader, Besra, Gurdyal S.
Publicado 2023

Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria

por Rana, Amrita K., Singh, Albel, Gurcha, Sudagar S., Cox, Liam R., Bhatt, Apoorva, Besra, Gurdyal S.
Publicado 2012

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

por Dao, Dee N., Sweeney, Kari, Hsu, Tsungda, Gurcha, Sudagar S., Nascimento, Ivan P., Roshevsky, Dan, Besra, Gurdyal S., Chan, John, Porcelli, Steven A., Jacobs, William R.
Publicado 2008

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant

por Mishra, Arun K., Klein, Christina, Gurcha, Sudagar S., Alderwick, Luke J., Babu, Ponnusamy, Hitchen, Paul G., Morris, Howard R., Dell, Anne, Besra, Gurdyal S., Eggeling, Lothar
Publicado 2008

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis

por Sambandan, Dhinakaran, Dao, Dee N., Weinrick, Brian C., Vilchèze, Catherine, Gurcha, Sudagar S., Ojha, Anil, Kremer, Laurent, Besra, Gurdyal S., Hatfull, Graham F., Jacobs, William R.
Publicado 2013

NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo

por Singh, Padam, Rawat, Srishti, Agrahari, Ashish Kumar, Singh, Manisha, Chugh, Saurabh, Gurcha, Sudagar, Singh, Albel, Abrahams, Katherine, Besra, Gurdyal S., Asthana, Shailendra, Rawat, Diwan S., Singh, Ramandeep
Publicado 2022

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

por Ivanova, Irina M., Nepogodiev, Sergey A., Saalbach, Gerhard, O'Neill, Ellis C., Urbaniak, Michael D., Ferguson, Michael A.J., Gurcha, Sudagar S., Besra, Gurdyal S., Field, Robert A.
Publicado 2017

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

por Kendall, Sharon L, Withers, Mike, Soffair, Catherine N, Moreland, Nicole J, Gurcha, Sudagar, Sidders, Ben, Frita, Rosangela, ten Bokum, Annemieke, Besra, Gurdyal S, Lott, J Shaun, Stoker, Neil G
Publicado 2007

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis

por Jankute, Monika, Alderwick, Luke J., Moorey, Alice R., Joe, Maju, Gurcha, Sudagar S., Eggeling, Lothar, Lowary, Todd L., Dell, Anne, Pang, Poh-Choo, Yang, Tiandi, Haslam, Stuart, Besra, Gurdyal S.
Publicado 2018

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

por Stoop, Esther J. M., Schipper, Tim, Rosendahl Huber, Sietske K., Nezhinsky, Alexander E., Verbeek, Fons J., Gurcha, Sudagar S., Besra, Gurdyal S., Vandenbroucke-Grauls, Christina M. J. E., Bitter, Wilbert, van der Sar, Astrid M.
Publicado 2011

Structure of the priming arabinosyltransferase AftA required for AG biosynthesis of Mycobacterium tuberculosis

por Gong, Yicheng, Wei, Chuancun, Wang, Jun, Mu, Nengjiang, Lu, Qinhong, Wu, Chengyao, Yan, Ning, Yang, Huifang, Zhao, Yao, Yang, Xiuna, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Hao, Zhiqiang, Da, Lintai, Besra, Gurdyal S., Rao, Zihe, Zhang, Lu
Publicado 2023

Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target

por Gurcha, Sudagar S., Usha, Veeraraghavan, Cox, Jonathan A. G., Fütterer, Klaus, Abrahams, Katherine A., Bhatt, Apoorva, Alderwick, Luke J., Reynolds, Robert C., Loman, Nicholas J., Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J., Ballell, Lluis, Hobrath, Judith V., Besra, Gurdyal S.
Publicado 2014

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

por Franklin, Aaron, Layton, Abigail J., Mize, Todd, Salgueiro, Vivian C., Sullivan, Rudi, Benedict, Samuel T., Gurcha, Sudagar S., Anso, Itxaso, Besra, Gurdyal S., Banzhaf, Manuel, Lovering, Andrew L., Williams, Spencer J., Guerin, Marcelo E., Scott, Nichollas E., Prados-Rosales, Rafael, Lowe, Elisabeth C., Moynihan, Patrick J.
Publicado 2023

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2)

por Zhang, Lu, Zhao, Yao, Gao, Ruogu, Li, Jun, Yang, Xiuna, Gao, Yan, Zhao, Wei, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Besra, Kajelle Kaur, Xu, Wenqing, Bi, Lijun, Zhang, Xian’en, Guddat, Luke W., Yang, Haitao, Wang, Quan, Besra, Gurdyal S., Rao, Zihe
Publicado 2020

Identification of KasA as the cellular target of an anti-tubercular scaffold

por Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Publicado 2016