Synergistic treatment of TS

por Gurkar, Aditi U., Finkel, Toren
Publicado 2017

Lipids as Regulators of Cellular Senescence

por Hamsanathan, Shruthi, Gurkar, Aditi U.
Publicado 2022

A Chemoptogenetic Tool for Spatiotemporal Induction of Oxidative DNA Lesions In Vivo

por Han, Suhao, Sims, Austin, Aceto, Anthony, Schmidt, Brigitte F., Bruchez, Marcel P., Gurkar, Aditi U.
Publicado 2023

Exonic Variants in Aging-Related Genes Are Predictive of Phenotypic Aging Status

por Breitbach, Megan E., Greenspan, Susan, Resnick, Neil M., Perera, Subashan, Gurkar, Aditi U., Absher, Devin, Levine, Arthur S.
Publicado 2019

c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks

por Barkley, Laura R., Palle, Komaraiah, Durando, Michael, Day, Tovah A., Gurkar, Aditi, Kakusho, Naoko, Li, Jianying, Masai, Hisao, Vaziri, Cyrus
Publicado 2012

Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress

por Gurkar, Aditi U., Chu, Kiki, Raj, Lakshmi, Bouley, Richard, Lee, Seung-Hwan, Kim, Young-Bum, Dunn, Sandra E., Mandinova, Anna, Lee, Sam W.
Publicado 2013

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

por Martinez, Bryan A, Reis Rodrigues, Pedro, Nuñez Medina, Ricardo M, Mondal, Prosenjit, Harrison, Neale J, Lone, Museer A, Webster, Amanda, Gurkar, Aditi U, Grill, Brock, Gill, Matthew S
Publicado 2020

Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

por Hamsanathan, Shruthi, Anthonymuthu, Tamil, Han, Suhao, Shinglot, Himaly, Siefken, Ella, Sims, Austin, Sen, Payel, Pepper, Hannah L., Snyder, Nathaniel W., Bayir, Hulya, Kagan, Valerian, Gurkar, Aditi U.
Publicado 2022

Selective killing of cancer cells with a small molecule targeting stress response to ROS

por Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U, Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Publicado 2011

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

por Gurkar, Aditi U., Robinson, Andria R., Cui, Yuxiang, Li, Xuesen, Allani, Shailaja K., Webster, Amanda, Muravia, Mariya, Fallahi, Mohammad, Weissbach, Herbert, Robbins, Paul D., Wang, Yinsheng, Kelley, Eric E., Croix, Claudette M. St., Niedernhofer, Laura J., Gill, Matthew S.
Publicado 2018

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

por Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.
Publicado 2020

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

por Zhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J., Li, Xuesen, Gurkar, Aditi U., McGowan, Sara J., Angelini, Luise, O’Kelly, Ryan, Li, Hongshuai, Corbo, Lana, Sano, Tokio, Nick, Heather, Pola, Enrico, Pilla, Smitha P.S., Ladiges, Warren C., Vo, Nam, Huard, Johnny, Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2020

Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy

por Henpita, Chathurika, Vyas, Rajesh, Healy, Chastity L., Kieu, Tra L., Gurkar, Aditi U., Yousefzadeh, Matthew J., Cui, Yuxiang, Lu, Aiping, Angelini, Luise A., O'Kelly, Ryan D., McGowan, Sara J., Chandrasekhar, Sanjay, Vanderpool, Rebecca R., Hennessy‐Wack, Danielle, Ross, Mark A., Bachman, Timothy N., McTiernan, Charles, Pillai, Smitha P. S., Ladiges, Warren, Lavasani, Mitra, Huard, Johnny, Beer‐Stolz, Donna, St. Croix, Claudette M., Watkins, Simon C., Robbins, Paul D., Mora, Ana L., Kelley, Eric E., Wang, Yinsheng, O'Connell, Timothy D., Niedernhofer, Laura J.
Publicado 2023

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

por Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C, Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K, Ikeno, Yuji, Hubbard, Gene B, Lenburg, Marc, O’Hara, Steven P, LaRusso, Nicholas F, Miller, Jordan D, Roos, Carolyn M, Verzosa, Grace C, LeBrasseur, Nathan K, Wren, Jonathan D, Farr, Joshua N, Khosla, Sundeep, Stout, Michael B, McGowan, Sara J, Fuhrmann-Stroissnigg, Heike, Gurkar, Aditi U, Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S, Navarro, Diana C, Sano, Tokio, Robbins, Paul D, Niedernhofer, Laura J, Kirkland, James L
Publicado 2015

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

por Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M., Frantz, Marie-Céline, Bell-Temin, Harris, Pope-Varsalona, Hannah, Gurkar, Aditi U., Nasto, Luigi A., Robinson, Renã A.S., Fuhrmann-Stroissnigg, Heike, Czerwinska, Jolanta, McGowan, Sara J., Cantu-Medellin, Nadiezhda, Harris, Jamie B., Maniar, Salony, Ross, Mark A., Trussoni, Christy E., LaRusso, Nicholas F., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Tudek, Barbara, Vo, Nam V., Rigatti, Lora H., Opresko, Patricia L., Stolz, Donna B., Watkins, Simon C., Burd, Christin E., Croix, Claudette M. St., Siuzdak, Gary, Yates, Nathan A., Robbins, Paul D., Wang, Yinsheng, Wipf, Peter, Kelley, Eric E., Niedernhofer, Laura J.
Publicado 2018