β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation

por Nisha, Gut, Jiri, Rosenthal, Philip J., Kumar, Vipan
Publicado 2014

Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials

por Blank, Brian R., Gut, Jiri, Rosenthal, Philip J., Renslo, Adam R.
Publicado 2023

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

por Blank, Brian R., Gut, Jiri, Rosenthal, Philip J., Renslo, Adam R.
Publicado 2017

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

por Marcellino, Chris, Gut, Jiri, Lim, K. C., Singh, Rahul, McKerrow, James, Sakanari, Judy
Publicado 2012

Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

por Aguiar, Luísa, Biosca, Arnau, Lantero, Elena, Gut, Jiri, Vale, Nuno, Rosenthal, Philip J., Nogueira, Fátima, Andreu, David, Fernàndez-Busquets, Xavier, Gomes, Paula
Publicado 2019

Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon

por Boyom, Fabrice Fekam, Ngouana, Vincent, Kemgne, Eugenie Aimée Madiesse, Zollo, Paul Henri Amvam, Menut, Chantal, Bessiere, Jean Marie, Gut, Jiri, Rosenthal, Philip Jon
Publicado 2010

Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3

por Subramanian, Shoba, Hardt, Markus, Choe, Youngchool, Niles, Richard K., Johansen, Eric B., Legac, Jennifer, Gut, Jiri, Kerr, Iain D., Craik, Charles S., Rosenthal, Philip J.
Publicado 2009

[(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity

por de J. Parra, Yonathan, Andueza L, Felix D., Ferrer M, Rosa E., Bruno Colmenarez, Julia, Acosta, María E., Charris, Jaime, Rosenthal, Philip J., Gut, Jiri
Publicado 2019

Falcipain 2 inhibitors and antiplasmodial compounds from a bio-guided fractionation of the fruits of Sorindeia juglandifolia A. Rich. (Anacardiaceae) growing in Cameroon

por Boyom, Fabrice F, Madiesse, Eugénie K, Bankeu, Jean J, Tsouh, Valere P, Lenta, Bruno N, Mbacham, Wilfred F, Tsamo, Etienne, Zollo, Paul HA, Gut, Jiri, Rosenthal, Philip J
Publicado 2010

Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid

por Dude, Marie-Adrienne, Kaeppler, Ulrich, Herb, Monika, Schiller, Markus, Schulz, Franziska, Vedder, Birgit, Heppner, Saskia, Pradel, Gabriele, Gut, Jiri, Rosenthal, Philip J., Schirmeister, Tanja, Leippe, Matthias, Gelhaus, Christoph
Publicado 2008

Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugi...

por Fischer, Chelsea, Ibiricu Urriza, Iosune, Bulman, Christina A., Lim, KC, Gut, Jiri, Lachau-Durand, Sophie, Engelen, Marc, Quirynen, Ludo, Tekle, Fetene, Baeten, Benny, Beerntsen, Brenda, Lustigman, Sara, Sakanari, Judy
Publicado 2019

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

por Vieira, Debora F., Choi, Jun Yong, Calvet, Claudia M., Siqueira-Neto, Jair Lage, Johnston, Jonathan B., Kellar, Danielle, Gut, Jiri, Cameron, Michael D., McKerrow, James H., Roush, William R., Podust, Larissa M.
Publicado 2014

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

por Palencia, Andrés, Liu, Ru-Juan, Lukarska, Maria, Gut, Jiri, Bougdour, Alexandre, Touquet, Bastien, Wang, En-Duo, Li, Xianfeng, Alley, M. R. K., Freund, Yvonne R., Rosenthal, Philip J., Hakimi, Mohamed-Ali, Cusack, Stephen
Publicado 2016

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

por Yamthe, Lauve Rachel Tchokouaha, Fokou, Patrick Valere Tsouh, Mbouna, Cedric Derick Jiatsa, Keumoe, Rodrigue, Ndjakou, Bruno Lenta, Djouonzo, Paul Toukam, Mfopa, Alvine Ngoutane, Legac, Jennifer, Tsabang, Nole, Gut, Jiri, Rosenthal, Philip J., Boyom, Fabrice Fekam
Publicado 2015

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

por Ang, Kenny K. H., Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B., Skrzypczynska, Katarzyna M., Debnath, Anjan, Engel, Juan C., Rosenthal, Philip J., McKerrow, James H., Arkin, Michelle R., Renslo, Adam R.
Publicado 2011

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

por Gunatilleke, Shamila S., Calvet, Claudia M., Johnston, Jonathan B., Chen, Chiung-Kuang, Erenburg, Grigori, Gut, Jiri, Engel, Juan C., Ang, Kenny K. H., Mulvaney, Joseph, Chen, Steven, Arkin, Michelle R., McKerrow, James H., Podust, Larissa M.
Publicado 2012

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

por Kamkumo, Raceline G, Ngoutane, Alvine M, Tchokouaha, Lauve RY, Fokou, Patrick VT, Madiesse, Eugénie AK, Legac, Jennifer, Kezetas, Jean JB, Lenta, Bruno N, Boyom, Fabrice F, Dimo, Theophile, Mbacham, Wilfred F, Gut, Jiri, Rosenthal, Philip J
Publicado 2012

4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

por Calvet, Claudia M., Vieira, Debora F., Choi, Jun Yong, Kellar, Danielle, Cameron, Michael D., Siqueira-Neto, Jair Lage, Gut, Jiri, Johnston, Jonathan B., Lin, Li, Khan, Susan, McKerrow, James H., Roush, William R., Podust, Larissa M.
Publicado 2014

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

por Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Publicado 2019

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

por Choy, Jonathan W, Bryant, Clifford, Calvet, Claudia M, Doyle, Patricia S, Gunatilleke, Shamila S, Leung, Siegfried S F, Ang, Kenny K H, Chen, Steven, Gut, Jiri, Oses-Prieto, Juan A, Johnston, Jonathan B, Arkin, Michelle R, Burlingame, Alma L, Taunton, Jack, Jacobson, Matthew P, McKerrow, James M, Podust, Larissa M, Renslo, Adam R
Publicado 2013