Using protein engineering to understand and modulate aggregation

por Ebo, Jessica S, Guthertz, Nicolas, Radford, Sheena E, Brockwell, David J
Publicado 2020

Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules

por Cawood, Emma E., Guthertz, Nicolas, Ebo, Jessica S., Karamanos, Theodoros K., Radford, Sheena E., Wilson, Andrew J.
Publicado 2020

The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

por Smith, Hugh I., Guthertz, Nicolas, Cawood, Emma E., Maya-Martinez, Roberto, Breeze, Alexander L., Radford, Sheena E.
Publicado 2020

Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2

por Gouge, Jerome, Satia, Karishma, Guthertz, Nicolas, Widya, Marcella, Thompson, Andrew James, Cousin, Pascal, Dergai, Oleksandr, Hernandez, Nouria, Vannini, Alessandro
Publicado 2015

Dimers of D76N-β(2)-microglobulin display potent antiamyloid aggregation activity

por Maya-Martinez, Roberto, Xu, Yong, Guthertz, Nicolas, Walko, Martin, Karamanos, Theodoros K., Sobott, Frank, Breeze, Alexander L., Radford, Sheena E.
Publicado 2022

Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

por Gouge, Jerome, Guthertz, Nicolas, Kramm, Kevin, Dergai, Oleksandr, Abascal-Palacios, Guillermo, Satia, Karishma, Cousin, Pascal, Hernandez, Nouria, Grohmann, Dina, Vannini, Alessandro
Publicado 2017

Disease-relevant β(2)-microglobulin variants share a common amyloid fold

por Wilkinson, Martin, Gallardo, Rodrigo U., Martinez, Roberto Maya, Guthertz, Nicolas, So, Masatomo, Aubrey, Liam D., Radford, Sheena E., Ranson, Neil A.
Publicado 2023

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

por Xu, Yong, Maya-Martinez, Roberto, Guthertz, Nicolas, Heath, George R., Manfield, Iain W., Breeze, Alexander L., Sobott, Frank, Foster, Richard, Radford, Sheena E.
Publicado 2022