A Benchmark Side-by-Side Comparison of Two Well-Established Protocols for in vitro Hematopoietic Differentiation From Human Pluripotent Stem Cells

por Gutierrez-Agüera, Francisco, Rodriguez-Cortez, Virginia, Petazzi, Paolo, Bueno, Clara, Menendez, Pablo
Publicado 2021

Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia

por Sánchez Martínez, Diego, Tirado, Néstor, Mensurado, Sofia, Martínez-Moreno, Alba, Romecín, Paola, Gutiérrez Agüera, Francisco, Correia, Daniel V, Silva-Santos, Bruno, Menéndez, Pablo
Publicado 2022

Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

por Sánchez‐Martínez, Diego, Gutiérrez‐Agüera, Francisco, Romecin, Paola, Vinyoles, Meritxell, Palomo, Marta, Tirado, Néstor, Zanetti, Samanta Romina, Juan, Manel, Carlet, Michela, Jeremias, Irmela, Menéndez, Pablo
Publicado 2021

CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity

por Bueno, Clara, Velasco-Hernandez, Talia, Gutiérrez-Agüera, Francisco, Zanetti, Samanta Romina, Baroni, Matteo L., Sánchez-Martínez, Diego, Molina, Oscar, Closa, Adria, Agraz-Doblás, Antonio, Marín, Pedro, Eyras, Eduardo, Varela, Ignacio, Menéndez, Pablo
Publicado 2019

Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells

por Petazzi, Paolo, Torres-Ruiz, Raul, Fidanza, Antonella, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Castaño, Julio, Rodriguez-Perales, Sandra, Díaz de la Guardia, Rafael, López-Millán, Belén, Bigas, Anna, Forrester, Lesley M., Bueno, Clara, Menéndez, Pablo
Publicado 2020

NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia

por Lopez-Millan, Belen, Sanchéz-Martínez, Diego, Roca-Ho, Heleia, Gutiérrez-Agüera, Francisco, Molina, Oscar, Diaz de la Guardia, Rafael, Torres-Ruiz, Raúl, Fuster, Jose Luís, Ballerini, Paola, Suessbier, Ute, Nombela-Arrieta, Cesar, Bueno, Clara, Menéndez, Pablo
Publicado 2019

Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope

por Velasco-Hernandez, Talia, Zanetti, Samanta Romina, Roca-Ho, Heleia, Gutierrez-Aguera, Francisco, Petazzi, Paolo, Sánchez-Martínez, Diego, Molina, Oscar, Baroni, Matteo Libero, Fuster, Jose Luis, Ballerini, Paola, Bueno, Clara, Fernandez-Fuentes, Narcis, Engel, Pablo, Menendez, Pablo
Publicado 2020

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

por Bueno, Clara, Calero-Nieto, Fernando J, Wang, Xiaonan, Valdés-Mas, Rafael, Gutiérrez-Agüera, Francisco, Roca-Ho, Heleia, Ayllon, Veronica, Real, Pedro J, Arambilet, David, Espinosa, Lluis, Torres-Ruiz, Raul, Agraz-Doblas, Antonio, Varela, Ignacio, de Boer, Jasper, Bigas, Anna, Gottgens, Bertie, Marschalek, Rolf, Menendez, Pablo
Publicado 2019

The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia

por Lopez-Millan, Belen, Costales, Paula, Gutiérrez-Agüera, Francisco, Díaz de la Guardia, Rafael, Roca-Ho, Heleia, Vinyoles, Meritxell, Rubio-Gayarre, Alba, Safi, Rémi, Castaño, Julio, Romecín, Paola Alejandra, Ramírez-Orellana, Manuel, Anguita, Eduardo, Jeremias, Irmela, Zamora, Lurdes, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Morís, Francisco, Menendez, Pablo
Publicado 2022

The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells

por Rodriguez-Cortez, Virginia C., Navarrete-Meneses, María Pilar, Molina, Oscar, Velasco-Hernandez, Talia, Gonzalez, Jessica, Romecin, Paola, Gutierrez-Agüera, Francisco, Roca-Ho, Heleia, Vinyoles, Meritxell, Kowarz, Eric, Marin, Pedro, Rodriguez-Perales, Sandra, Gomez-Marin, Carlos, Perez-Vera, Patricia, Cortes-Ledesma, Felipe, Bigas, Anna, Terron, Andrea, Bueno, Clara, Menendez, Pablo
Publicado 2021

A novel and efficient tandem CD19- and CD22-directed CAR for B cell ALL

por Zanetti, Samanta Romina, Velasco-Hernandez, Talia, Gutierrez-Agüera, Francisco, Díaz, Víctor M., Romecín, Paola Alejandra, Roca-Ho, Heleia, Sánchez-Martínez, Diego, Tirado, Néstor, Baroni, Matteo Libero, Petazzi, Paolo, Torres-Ruiz, Raúl, Molina, Oscar, Bataller, Alex, Fuster, José Luis, Ballerini, Paola, Juan, Manel, Jeremias, Irmela, Bueno, Clara, Menéndez, Pablo
Publicado 2022

Engraftment characterization of risk-stratified AML in NSGS mice

por Díaz de la Guardia, Rafael, Velasco-Hernandez, Talía, Gutiérrez-Agüera, Francisco, Roca-Ho, Heleia, Molina, Oscar, Nombela-Arrieta, Cesar, Bataller, Alex, Fuster, Jose Luis, Anguita, Eduardo, Vives, Susana, Zamora, Lurdes, Nomdedeu, Josep, Gómez-Casares, María Teresa, Ramírez-Orellana, Manuel, Lapillonne, Helene, Ramos-Mejia, Verónica, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Lopez-Millan, Belen, Menéndez, Pablo
Publicado 2021

IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/...

por Lopez-Millan, Belen, Diaz de la Guardia, Rafael, Roca-Ho, Heleia, Anguita, Eduardo, Islam, Abul B. M. M. K., Romero-Moya, Damia, Prieto, Cristina, Gutierrez-Agüera, Francisco, Bejarano-Garcia, Jose Antonio, Perez-Simon, Jose Antonio, Costales, Paula, Rovira, Montse, Marín, Pedro, Menendez, Silvia, Iglesias, Mar, Fuster, Jose Luis, Urbano-Ispizua, Alvaro, Anjos-Afonso, Fernando, Bueno, Clara, Menendez, Pablo
Publicado 2018

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

por Baroni, Matteo Libero, Sanchez Martinez, Diego, Gutierrez Aguera, Francisco, Roca Ho, Heleia, Castella, Maria, Zanetti, Samanta Romina, Velasco Hernandez, Talia, Diaz de la Guardia, Rafael, Castaño, Julio, Anguita, Eduardo, Vives, Susana, Nomdedeu, Josep, Lapillone, Helene, Bras, Anne E, van der Velden, Vincent H J, Junca, Jordi, Marin, Pedro, Bataller, Alex, Esteve, Jordi, Vick, Binje, Jeremias, Irmela, Lopez, Angel, Sorigue, Marc, Bueno, Clara, Menendez, Pablo
Publicado 2020

CD34(+)CD19(−)CD22(+) B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

por Bueno, Clara, Barrera, Susana, Bataller, Alex, Ortiz-Maldonado, Valentín, Elliot, Natalina, O’Byrne, Sorcha, Wang, Guanlin, Rovira, Montse, Gutierrez-Agüera, Francisco, Trincado, Juan L., González-González, María, Morgades, Mireia, Sorigué, Marc, Bárcena, Paloma, Zanetti, Samanta Romina, Torrebadell, Montse, Vega-Garcia, Nerea, Rives, Susana, Mallo, Mar, Sole, Francesc, Mead, Adam J., Roberts, Irene, Thongjuea, Supat, Psaila, Bethan, Juan, Manel, Delgado, Julio, Urbano-Ispizúa, Alvaro, Ribera, Josep María, Orfao, Alberto, Roy, Anindita, Menendez, Pablo
Publicado 2022

Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers

por Blanco, Belén, Ramírez-Fernández, Ángel, Bueno, Clara, Argemí-Muntadas, Lidia, Fuentes, Patricia, Aguilar-Sopeña, Óscar, Gutierrez-Agüera, Francisco, Zanetti, Samanta Romina, Tapia-Galisteo, Antonio, Díez-Alonso, Laura, Segura-Tudela, Alejandro, Castellà, Maria, Marzal, Berta, Betriu, Sergi, Harwood, Seandean L., Compte, Marta, Lykkemark, Simon, Erce-Llamazares, Ainhoa, Rubio-Pérez, Laura, Jiménez-Reinoso, Anaïs, Domínguez-Alonso, Carmen, Neves, Maria, Morales, Pablo, Paz-Artal, Estela, Guedan, Sonia, Sanz, Laura, Toribio, María L., Roda-Navarro, Pedro, Juan, Manel, Menéndez, Pablo, Álvarez-Vallina, Luis
Publicado 2022