An Automated Approach to Efficiently Reformat a Large Collection of Compounds

por Cui, Jimmy, Chai, Sergio C, Shelat, Anang A, Guy, R. Kiplin, Chen, Taosheng
Publicado 2011

Amine Containing Analogs of Sulindac for Cancer Prevention

por Mathew, Bini, Hobrath, Judith V., Connelly, Michele C., Guy, R. Kiplin, Reynolds, Robert C.
Publicado 2018

Oxazole and thiazole analogs of sulindac for cancer prevention

por Mathew, Bini, Hobrath, Judith V, Connelly, Michele C, Guy, R Kiplin, Reynolds, Robert C
Publicado 2018

Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia

por Jarusiewicz, Jamie A., Jeon, Jae Yoon, Connelly, Michele C., Chen, Yizhe, Yang, Lei, Baker, Sharyn D., Guy, R. Kiplin
Publicado 2017

Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

por Mathew, Bini, Hobrath, Judith Varady, Ross, Larry, Connelly, Michele C., Lofton, Hava, Rajagopalan, Malini, Guy, R. Kiplin, Reynolds, Robert C.
Publicado 2016

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

por Pettersson, Mariell, Quant, Maria, Min, Jaeki, Iconaru, Luigi, Kriwacki, Richard W., Waddell, M. Brett, Guy, R. Kiplin, Luthman, Kristina, Grøtli, Morten
Publicado 2015

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

por Pettersson, Mariell, Bliman, David, Jacobsson, Jimmy, Nilsson, Jesper R., Min, Jaeki, Iconaru, Luigi, Guy, R. Kiplin, Kriwacki, Richard W., Andréasson, Joakim, Grøtli, Morten
Publicado 2015

Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M

por Kim, Ho Shin, Hammill, Jared T., Scott, Daniel C., Chen, Yizhe, Rice, Amy L., Pistel, William, Singh, Bhuvanesh, Schulman, Brenda A., Guy, R. Kiplin
Publicado 2021

Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–P...

por Vara, Brandon A., Mayasundari, Anand, Tellis, John C., Danneman, Michael W., Arredondo, Vanessa, Davis, Tyler A., Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N.
Publicado 2014

Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma

por Pritchard, Eleanor M., Stewart, Elizabeth, Zhu, Fangyi, Bradley, Cori, Griffiths, Lyra, Yang, Lei, Suryadevara, Praveen Kumar, Zhang, Jiakun, Freeman, Burgess B., Guy, R. Kiplin, Dyer, Michael A.
Publicado 2014

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

por Ortiz, Diana, Guiguemde, W. Armand, Johnson, Alex, Elya, Carolyn, Anderson, Johanna, Clark, Julie, Connelly, Michele, Yang, Lei, Min, Jaeki, Sato, Yuko, Guy, R. Kiplin, Landfear, Scott M.
Publicado 2015

Anticancer Properties of Distinct Antimalarial Drug Classes

por Hooft van Huijsduijnen, Rob, Guy, R. Kiplin, Chibale, Kelly, Haynes, Richard K., Peitz, Ingmar, Kelter, Gerhard, Phillips, Margaret A., Vennerstrom, Jonathan L., Yuthavong, Yongyuth, Wells, Timothy N. C.
Publicado 2013

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

por Zhao, Yu, Cushing, Patrick R., Smithson, David C., Pellegrini, Maria, Pletnev, Alexandre A., Al-Ayyoubi, Sahar, Grassetti, Andrew V., Gerber, Scott A., Guy, R. Kiplin, Madden, Dean R.
Publicado 2018

Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain

por Zhao, Yu, Cushing, Patrick R., Smithson, David C., Pellegrini, Maria, Pletnev, Alexandre A., Al-Ayyoubi, Sahar, Grassetti, Andrew V., Gerber, Scott A., Guy, R. Kiplin, Madden, Dean R.
Publicado 2018

Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

por Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L., Shackleford, David M., O’Loughlin, Kathleen G., Charman, Susan A., Mirsalis, Jon C., Guy, R. Kiplin
Publicado 2021

On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53

por Bista, Michal, Smithson, David, Pecak, Aleksandra, Salinas, Gabriella, Pustelny, Katarzyna, Min, Jaeki, Pirog, Artur, Finch, Kristin, Zdzalik, Michal, Waddell, Brett, Wladyka, Benedykt, Kedracka-Krok, Sylwia, Dyer, Michael A., Dubin, Grzegorz, Guy, R. Kiplin
Publicado 2012

Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

por SheelaNair, Arya, Romanczuk, Aleksandra S., Aogo, Rosemary A., Haldar, Rohit Nemai, Lansink, Lianne I. M., Cromer, Deborah, Salinas, Yandira G., Guy, R. Kiplin, McCarthy, James S., Davenport, Miles P., Haque, Ashraful, Khoury, David S.
Publicado 2022

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

por Ortiz, Diana, Guiguemde, W. Armand, Hammill, Jared T., Carrillo, Angela K., Chen, Yizhe, Connelly, Michele, Stalheim, Kayla, Elya, Carolyn, Johnson, Alex, Min, Jaeki, Shelat, Anang, Smithson, David C., Yang, Lei, Zhu, Fangyi, Guy, R. Kiplin, Landfear, Scott M.
Publicado 2017

Repositioning: the fast track to new anti-malarial medicines?

por Lotharius, Julie, Gamo-Benito, Francisco Javier, Angulo-Barturen, Iñigo, Clark, Julie, Connelly, Michele, Ferrer-Bazaga, Santiago, Parkinson, Tanya, Viswanath, Pavithra, Bandodkar, Balachandra, Rautela, Nikhil, Bharath, Sowmya, Duffy, Sandra, Avery, Vicky M, Möhrle, Jörg J, Guy, R Kiplin, Wells, Timothy
Publicado 2014

A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML

por Drenberg, Christina D., Shelat, Anang, Dang, Jinjun, Cotton, Anitria, Orwick, Shelley J., Li, Mengyu, Jeon, Jae Yoon, Fu, Qiang, Buelow, Daelynn R., Pioso, Marissa, Hu, Shuiying, Inaba, Hiroto, Ribeiro, Raul C., Rubnitz, Jeffrey E., Gruber, Tanja A., Guy, R. Kiplin, Baker, Sharyn D.
Publicado 2019