Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas

por Liang, Jiaxin, Yu, Deyang, Luo, Chi, Bennett, Christopher, Jedrychowski, Mark, Gygi, Steve P., Widlund, Hans R., Puigserver, Pere
Publicado 2023

Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly

por Lucena, Rafael, Dephoure, Noah, Gygi, Steve P., Kellogg, Douglas R., Tallada, Victor A., Daga, Rafael R., Jimenez, Juan
Publicado 2015

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation

por Zeng, Xing, Jedrychowski, Mark P., Chen, Yi, Serag, Sara, Lavery, Gareth G., Gygi, Steve P., Spiegelman, Bruce M.
Publicado 2016

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells

por Soustek, Meghan S., Balsa, Eduardo, Barrow, Joeva J., Jedrychowski, Mark, Vogel, Rutger, Jan Smeitink, Gygi, Steve P., Puigserver, Pere
Publicado 2018

Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma

por Zhou, Shuang, Appleman, Vicky A, Rose, Christopher M, Jun, Hyun Jung, Yang, Juechen, Zhou, Yue, Bronson, Roderick T, Gygi, Steve P, Charest, Al
Publicado 2018

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition

por Ganji, Rakesh, Paulo, Joao A., Xi, Yuecheng, Kline, Ian, Zhu, Jiang, Clemen, Christoph S., Weihl, Conrad C., Purdy, John G., Gygi, Steve P., Raman, Malavika
Publicado 2023

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity

por Gyuris, Aron, Navarrete-Perea, Jose, Jo, Ala, Cristea, Simona, Zhou, Shuang, Fraser, Kyle, Wei, Zhiyun, Krichevsky, Anna M., Weissleder, Ralph, Lee, Hakho, Gygi, Steve P., Charest, Al
Publicado 2019

Tetracyclines promote survival and fitness in mitochondrial disease models

por Perry, Elizabeth A., Bennett, Christopher F., Luo, Chi, Balsa, Eduardo, Jedrychowski, Mark, O’Malley, Katherine, Latorre-Muro, Pedro, Ladley, Richard Porter, Reda, Kamar, Wright, Peter M., Gygi, Steve P., Myers, Andrew G., Puigserver, Pere
Publicado 2021

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

por Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.
Publicado 2016

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

por Jun, Hyun Jung, Appleman, Vicky A., Wu, Hua-Jun, Rose, Christopher M., Pineda, Javier J., Yeo, Alan T., Delcuze, Bethany, Lee, Charlotte, Gyuris, Aron, Zhu, Haihao, Woolfenden, Steve, Bronisz, Agnieszka, Nakano, Ichiro, Chiocca, Ennio A., Bronson, Roderick T., Ligon, Keith L., Sarkaria, Jann N., Gygi, Steve P., Michor, Franziska, Mitchison, Timothy J., Charest, Al
Publicado 2018