The Glucosylceramide Synthase Inhibitor PDMP Causes Lysosomal Lipid Accumulation and mTOR Inactivation

por Hartwig, Pia, Höglinger, Doris
Publicado 2021

A Click Cage: Organelle‐Specific Uncaging of Lipid Messengers

por Wagner, Nicolai, Stephan, Milena, Höglinger, Doris, Nadler, André
Publicado 2018

Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor

por Altuzar, Janathan, Notbohm, Judith, Stein, Frank, Haberkant, Per, Hempelmann, Pia, Heybrock, Saskia, Worsch, Jutta, Saftig, Paul, Höglinger, Doris
Publicado 2023

Intracellular sphingosine releases calcium from lysosomes

por Höglinger, Doris, Haberkant, Per, Aguilera-Romero, Auxiliadora, Riezman, Howard, Porter, Forbes D, Platt, Frances M, Galione, Antony, Schultz, Carsten
Publicado 2015

The sterol transporter STARD3 transports sphingosine at ER-lysosome contact sites

por Hempelmann, Pia, Lolicato, Fabio, Graziadei, Andrea, Brown, Ryan D. R., Spiegel, Sarah, Rappsilber, Juri, Nickel, Walter, Höglinger, Doris, Jamecna, Denisa
Publicado 2023

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

por Fineran, Paul, Lloyd-Evans, Emyr, Lack, Nathan A., Platt, Nick, Davis, Lianne C., Morgan, Anthony J., Höglinger, Doris, Tatituri, Raju Venkata V., Clark, Simon, Williams, Ian M., Tynan, Patricia, Al Eisa, Nada, Nazarova, Evgeniya, Williams, Ann, Galione, Antony, Ory, Daniel S., Besra, Gurdyal S., Russell, David G., Brenner, Michael B., Sim, Edith, Platt, Frances M.
Publicado 2017

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

por Griess, Kerstin, Rieck, Michael, Müller, Nadine, Karsai, Gergely, Hartwig, Sonja, Pelligra, Angela, Hardt, Robert, Schlegel, Caroline, Kuboth, Jennifer, Uhlemeyer, Celina, Trenkamp, Sandra, Jeruschke, Kay, Weiss, Jürgen, Peifer-Weiss, Leon, Xu, Weiwei, Cames, Sandra, Yi, Xiaoyan, Cnop, Miriam, Beller, Mathias, Stark, Holger, Kondadi, Arun Kumar, Reichert, Andreas S., Markgraf, Daniel, Wammers, Marianne, Häussinger, Dieter, Kuss, Oliver, Lehr, Stefan, Eizirik, Decio, Lickert, Heiko, Lammert, Eckhard, Roden, Michael, Winter, Dominic, Al-Hasani, Hadi, Höglinger, Doris, Hornemann, Thorsten, Brüning, Jens C., Belgardt, Bengt-Frederik
Publicado 2022