Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

por Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Publicado 2020

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

por Hölting, Tilman L. B., Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J., Funk, Cornelius M., Geyer, Florian H., Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L., Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Künkele, Annette, Klauschen, Frederick, Grünewald, Thomas G. P., Knott, Maximilian M. L.
Publicado 2022

Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma

por Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela C., Hölting, Tilman L. B., Musa, Julian, Knott, Max M. L., Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S., Romero-Pérez, Laura, Gerke, Julia S., Orth, Martin F., Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas G. P.
Publicado 2019

Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

por Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J., Romero-Pérez, Laura, Wehweck, Fabienne S., Musa, Julian, Bestvater, Felix, Knott, Maximilian M. L., Hölting, Tilman L. B., Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Publicado 2021

Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer

por Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Publicado 2021

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

por Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.
Publicado 2020

Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

por Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.
Publicado 2020

Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients

por Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.
Publicado 2019

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma

por Orth, Martin F., Hölting, Tilman L. B., Dallmayer, Marlene, Wehweck, Fabienne S., Paul, Tanja, Musa, Julian, Baldauf, Michaela C., Surdez, Didier, Delattre, Olivier, Knott, Maximilian M. L., Romero-Pérez, Laura, Kasan, Merve, Cidre-Aranaz, Florencia, Gerke, Julia S., Ohmura, Shunya, Li, Jing, Marchetto, Aruna, Henssen, Anton G., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Kanaseki, Takayuki, Bertram, Stefanie, Dirksen, Uta, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G. P.
Publicado 2020

Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma

por Cidre-Aranaz, Florencia, Li, Jing, Hölting, Tilman L. B., Orth, Martin F., Imle, Roland, Kutschmann, Stefanie, Ammirati, Giulia, Ceranski, Katharina, Carreño-Gonzalez, Martha Julia, Kasan, Merve, Marchetto, Aruna, Funk, Cornelius M., Bestvater, Felix, Bersini, Simone, Arrigoni, Chiara, Moretti, Matteo, Thiel, Uwe, Baumhoer, Daniel, Sahm, Felix, Pfister, Stefan M., Hartmann, Wolfgang, Dirksen, Uta, Romero-Pérez, Laura, Banito, Ana, Ohmura, Shunya, Musa, Julian, Kirchner, Thomas, Knott, Maximilian M. L., Grünewald, Thomas G. P.
Publicado 2022

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

por Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.
Publicado 2019