The biological function of β-secretase

por Haass, Christian
Publicado 2013

A lipid boundary separates APP and secretases and limits amyloid β-peptide generation

por Kaether, Christoph, Haass, Christian
Publicado 2004

If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?

por Haass, Christian, Selkoe, Dennis
Publicado 2022

Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models

por Kleinberger, Gernot, Capell, Anja, Haass, Christian, Van Broeckhoven, Christine
Publicado 2012

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

por Ehehalt, Robert, Keller, Patrick, Haass, Christian, Thiele, Christoph, Simons, Kai
Publicado 2003

Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology

por Solchenberger, Barbara, Russell, Claire, Kremmer, Elisabeth, Haass, Christian, Schmid, Bettina
Publicado 2015

γ‐Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics

por Steiner, Andrea, Schlepckow, Kai, Brunner, Bettina, Steiner, Harald, Haass, Christian, Hagn, Franz
Publicado 2020

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

por Schlepckow, Kai, Kleinberger, Gernot, Fukumori, Akio, Feederle, Regina, Lichtenthaler, Stefan F, Steiner, Harald, Haass, Christian
Publicado 2017

Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

por Kaether, Christoph, Lammich, Sven, Edbauer, Dieter, Ertl, Michaela, Rietdorf, Jens, Capell, Anja, Steiner, Harald, Haass, Christian
Publicado 2002

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

por Ohki, Yu, Wenninger-Weinzierl, Andrea, Hruscha, Alexander, Asakawa, Kazuhide, Kawakami, Koichi, Haass, Christian, Edbauer, Dieter, Schmid, Bettina
Publicado 2017

A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

por Pesämaa, Ida, Müller, Stephan A., Robinson, Sophie, Darcher, Alana, Paquet, Dominik, Zetterberg, Henrik, Lichtenthaler, Stefan F., Haass, Christian
Publicado 2023

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

por Götzl, Julia K., Colombo, Alessio-Vittorio, Fellerer, Katrin, Reifschneider, Anika, Werner, Georg, Tahirovic, Sabina, Haass, Christian, Capell, Anja
Publicado 2018

Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

por Fett, Mareike E., Pilsl, Anna, Paquet, Dominik, van Bebber, Frauke, Haass, Christian, Tatzelt, Jörg, Schmid, Bettina, Winklhofer, Konstanze F.
Publicado 2010

Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease

por McCarter, Joanna F., Liebscher, Sabine, Bachhuber, Teresa, Abou-Ajram, Claudia, Hübener, Mark, Hyman, Bradley T., Haass, Christian, Meyer-Luehmann, Melanie
Publicado 2013

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

por Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian
Publicado 2016

Aβ oligomers trigger and accelerate Aβ seeding

por Katzmarski, Natalie, Ziegler‐Waldkirch, Stephanie, Scheffler, Nina, Witt, Christian, Abou‐Ajram, Claudia, Nuscher, Brigitte, Prinz, Marco, Haass, Christian, Meyer‐Luehmann, Melanie
Publicado 2019

Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders

por Aly, Lilian, Strauß, Eva-Maria, Feucht, Nikolaus, Weiß, Isabella, Berthele, Achim, Mitsdoerffer, Meike, Haass, Christian, Hemmer, Bernhard, Maier, Mathias, Korn, Thomas, Knier, Benjamin
Publicado 2021

sTREM2 is associated with amyloid‐related p‐tau increases and glucose hypermetabolism in Alzheimer's disease

por Biel, Davina, Suárez‐Calvet, Marc, Hager, Paul, Rubinski, Anna, Dewenter, Anna, Steward, Anna, Roemer, Sebastian, Ewers, Michael, Haass, Christian, Brendel, Matthias, Franzmeier, Nicolai
Publicado 2023

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

por Kretner, Benedikt, Trambauer, Johannes, Fukumori, Akio, Mielke, Janina, Kuhn, Peer‐Hendrik, Kremmer, Elisabeth, Giese, Armin, Lichtenthaler, Stefan F, Haass, Christian, Arzberger, Thomas, Steiner, Harald
Publicado 2016

Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

por Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja
Publicado 2020