SUN-662 Praliciguat, a Clinical-Stage Soluble Guanylate Cyclase Stimulator, Improves Lipid Handling and Insulin Sensitivity in Diet-Induced Obese Mice

por Schwartzkopf, Chad D, Liu, Guang, Hadcock, John R, Currie, Mark G, Masferrer, Jamie L, Jones, Juli E
Publicado 2020

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

por Selimkhanov, Jangir, Thompson, W. Clayton, Patterson, Terrell A., Hadcock, John R., Scott, Dennis O., Maurer, Tristan S., Musante, Cynthia J.
Publicado 2016

Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

por Schwartzkopf, Chad D., Hadcock, John R., Liu, Guang, Germano, Peter, Roux, Julien, Shea, Courtney M., Buys, Emmanuel S., Jones, Juli E.
Publicado 2022

Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice

por Bernardo, Barbara L., Wachtmann, Timothy S., Cosgrove, Patricia G., Kuhn, Max, Opsahl, Alan C., Judkins, Kyle M., Freeman, Thomas B., Hadcock, John R., LeBrasseur, Nathan K.
Publicado 2010

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice

por Mukashyaka, Marie Claire, Wu, Chia-Ling, Ha, Kristin, Zhang, Jianbo, Wood, Jenna, Foley, Samantha, Mastis, Bryan, Jungels, Nino, Sun, Huadong, Shadid, Mohammad, Harriman, Shawn, Hadcock, John R.
Publicado 2021

Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons

por Sanchez-Alavez, Manuel, Tabarean, Iustin V., Osborn, Olivia, Mitsukawa, Kayo, Schaefer, Jean, Dubins, Jeffrey, Holmberg, Kristina H., Klein, Izabella, Klaus, Joe, Gomez, Luis F., Kolb, Hartmuth, Secrest, James, Jochems, Jeanine, Myashiro, Kevin, Buckley, Peter, Hadcock, John R., Eberwine, James, Conti, Bruno, Bartfai, Tamas
Publicado 2010

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB(1)) Receptor Antagonist

por Hadcock, John R, Carpino, Philip A, Iredale, Philip A, Dow, Robert L, Gautreau, Denise, Thiede, Lucinda, Kelly-Sullivan, Dawn, Lizano, Jeffrey S, Liu, Xingrong, Van Deusen, Jeffrey, Ward, Karen M, O'Connor, Rebecca E, Black, Shawn C, Griffith, David A, Scott, Dennis O
Publicado 2010

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

por Correia, Susana S., Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G., Tobin, Jenny V., Schwartzkopf, Chad D., Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R., Currie, Mark G., Hadcock, John R., Winrow, Christopher J., Jones, Juli E.
Publicado 2021

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

por Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Publicado 2021