Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV’s Envelope Protein on Viral Replication in Cell Culture

por Haddox, Hugh K., Dingens, Adam S., Bloom, Jesse D.
Publicado 2016

Mapping mutational effects along the evolutionary landscape of HIV envelope

por Haddox, Hugh K, Dingens, Adam S, Hilton, Sarah K, Overbaugh, Julie, Bloom, Jesse D
Publicado 2018

Jointly modeling deep mutational scans identifies shifted mutational effects among SARS-CoV-2 spike homologs

por Haddox, Hugh K., Galloway, Jared G., Dadonaite, Bernadeta, Bloom, Jesse D., Matsen IV, Frederick A., DeWitt, William S.
Publicado 2023

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation

por Kim, Tae-Eun, Tsuboyama, Kotaro, Houliston, Scott, Martell, Cydney M., Phoumyvong, Claire M., Lemak, Alexander, Haddox, Hugh K., Arrowsmith, Cheryl H., Rocklin, Gabriel J.
Publicado 2022

De novo design of obligate ABC-type heterotrimeric proteins

por Bermeo, Sherry, Favor, Andrew, Chang, Ya-Ting, Norris, Andrew, Boyken, Scott E., Hsia, Yang, Haddox, Hugh K., Xu, Chunfu, Brunette, T. J., Wysocki, Vicki H., Bhabha, Gira, Ekiert, Damian C., Baker, David
Publicado 2022

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

por Dingens, Adam S., Acharya, Priyamvada, Haddox, Hugh K., Rawi, Reda, Xu, Kai, Chuang, Gwo-Yu, Wei, Hui, Zhang, Baoshan, Mascola, John R., Carragher, Bridget, Potter, Clinton S., Overbaugh, Julie, Kwong, Peter D., Bloom, Jesse D.
Publicado 2018

De novo design of immunoglobulin-like domains

por Chidyausiku, Tamuka M., Mendes, Soraia R., Klima, Jason C., Nadal, Marta, Eckhard, Ulrich, Roel-Touris, Jorge, Houliston, Scott, Guevara, Tibisay, Haddox, Hugh K., Moyer, Adam, Arrowsmith, Cheryl H., Gomis-Rüth, F. Xavier, Baker, David, Marcos, Enrique
Publicado 2022

Computational design of sequence-specific DNA-binding proteins

por Glasscock, Cameron J., Pecoraro, Robert, McHugh, Ryan, Doyle, Lindsey A., Chen, Wei, Boivin, Olivier, Lonnquist, Beau, Na, Emily, Politanska, Yuliya, Haddox, Hugh K., Cox, David, Norn, Christoffer, Coventry, Brian, Goreshnik, Inna, Vafeados, Dionne, Lee, Gyu Rie, Gordan, Raluca, Stoddard, Barry L., DiMaio, Frank, Baker, David
Publicado 2023

Large-scale design and refinement of stable proteins using sequence-only models

por Singer, Jedediah M., Novotney, Scott, Strickland, Devin, Haddox, Hugh K., Leiby, Nicholas, Rocklin, Gabriel J., Chow, Cameron M., Roy, Anindya, Bera, Asim K., Motta, Francis C., Cao, Longxing, Strauch, Eva-Maria, Chidyausiku, Tamuka M., Ford, Alex, Ho, Ethan, Zaitzeff, Alexander, Mackenzie, Craig O., Eramian, Hamed, DiMaio, Frank, Grigoryan, Gevorg, Vaughn, Matthew, Stewart, Lance J., Baker, David, Klavins, Eric
Publicado 2022