A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies

por Rosskopf, Sandra, Leitner, Judith, Paster, Wolfgang, Morton, Laura T., Hagedoorn, Renate S., Steinberger, Peter, Heemskerk, Mirjam H.M.
Publicado 2018

Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4(+) T Cells

por van Loenen, Marleen M., Hagedoorn, Renate S., de Boer, Renate, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Publicado 2013

Reprogramming of Virus-specific T Cells into Leukemia-reactive T Cells Using T Cell Receptor Gene Transfer

por Heemskerk, Mirjam H.M., Hoogeboom, Manja, Hagedoorn, Renate, Kester, Michel G.D., Willemze, Roel, Falkenburg, J.H. Frederik
Publicado 2004

Combining BCMA-targeting CAR T cells with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma

por Wachsmann, Tassilo L. A., Meeuwsen, Miranda H., Remst, Dennis F. G., Buchner, Karen, Wouters, Anne K., Hagedoorn, Renate S., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Publicado 2023

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

por Luk, Sietse J, van der Steen, Dirk M, Hagedoorn, Renate S, Jordanova, Ekaterina S, Schilham, Marco W, Bovée, Judith VMG, Cleven, Arjen HG, Falkenburg, JH Frederik, Szuhai, Karoly, Heemskerk, Mirjam HM
Publicado 2018

SARS-CoV-2-specific CD4(+) and CD8(+) T cell responses can originate from cross-reactive CMV-specific T cells

por Pothast, Cilia R, Dijkland, Romy C, Thaler, Melissa, Hagedoorn, Renate S, Kester, Michel GD, Wouters, Anne K, Hiemstra, Pieter S, van Hemert, Martijn J, Gras, Stephanie, Falkenburg, JH Frederik, Heemskerk, Mirjam HM
Publicado 2022

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential

por van Amerongen, Rosa A., Morton, Laura T., Chaudhari, Umesh G., Remst, Dennis F.G., Hagedoorn, Renate S., van den Berg, Cathelijne W., Freund, Christian, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Publicado 2023

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

por Wachsmann, Tassilo L. A., Wouters, Anne K., Remst, Dennis F. G., Hagedoorn, Renate S., Meeuwsen, Miranda H., van Diest, Eline, Leusen, Jeanette, Kuball, Jürgen, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Publicado 2022

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer

por Jahn, Lorenz, Hagedoorn, Renate S., van der Steen, Dirk M., Hombrink, Pleun, Kester, Michel G.D., Schoonakker, Marjolein P., de Ridder, Daniëlle, van Veelen, Peter A., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Publicado 2016

Generation of CD20-specific TCRs for TCR gene therapy of CD20(low) B-cell malignancies insusceptible to CD20-targeting antibodies

por Jahn, Lorenz, van der Steen, Dirk M., Hagedoorn, Renate S., Hombrink, Pleun, Kester, Michel G.D., Schoonakker, Marjolein P., de Ridder, Daniëlle, van Veelen, Peter A., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Publicado 2016

Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells

por van der Wulp, Willemijn, Gram, Anna M., Bleijlevens, Boris, Hagedoorn, Renate S., Araman, Can, Kim, Robbert Q., Drijfhout, Jan Wouter, Parren, Paul W. H. I., Hibbert, Richard G., Hoeben, Rob C., van Kasteren, Sander I., Schuurman, Janine, Ressing, Maaike E., Heemskerk, Mirjam H. M.
Publicado 2023

HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical St...

por van Balen, Peter, Jedema, Inge, van Loenen, Marleen M., de Boer, Renate, van Egmond, H. M., Hagedoorn, Renate S., Hoogstaten, Conny, Veld, Sabrina A. J., Hageman, Lois, van Liempt, P. A. G., Zwaginga, Jaap-Jan, Meij, Pauline, Veelken, H., Falkenburg, J. H. F., Heemskerk, Mirjam H. M.
Publicado 2020

WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma

por van Amerongen, Rosa A, Hagedoorn, Renate S, Remst, Dennis F G, Assendelft, Danique C, van der Steen, Dirk M, Wouters, Anne K, van de Meent, Marian, Kester, Michel G D, de Ru, Arnoud H, Griffioen, Marieke, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Publicado 2022

Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain

por Meeuwsen, Miranda H., Wouters, Anne K., Wachsmann, Tassilo L. A., Hagedoorn, Renate S., Kester, Michel G. D., Remst, Dennis F. G., van der Steen, Dirk M., de Ru, Arnoud H., van Hees, Els P., Kremer, Martijn, Griffioen, Marieke, van Veelen, Peter A., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Publicado 2023

A library of cancer testis specific T cell receptors for T cell receptor gene therapy

por de Rooij, Marije A.J., Remst, Dennis F.G., van der Steen, Dirk M., Wouters, Anne K., Hagedoorn, Renate S., Kester, Michel G.D., Meeuwsen, Miranda H., Wachsmann, Tassilo L.A., de Ru, Arnoud H., van Veelen, Peter A., Verdegaal, Els M.E., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Publicado 2023

A library of cancer testis specific T cell receptors for T cell receptor gene therapy

por de Rooij, Marije A.J., Remst, Dennis F.G., van der Steen, Dirk M., Wouters, Anne K., Hagedoorn, Renate S., Kester, Michel G.D., Meeuwsen, Miranda H., Wachsmann, Tassilo L.A., de Ru, Arnoud H., van Veelen, Peter A., Verdegaal, Els M.E., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Publicado 2022

PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer

por van Amerongen, Rosa A., Tuit, Sander, Wouters, Anne K., van de Meent, Marian, Siekman, Sterre L., Meeuwsen, Miranda H., Wachsmann, Tassilo L. A., Remst, Dennis F. G., Hagedoorn, Renate S., van der Steen, Dirk M., de Ru, Arnoud H., Verdegaal, Els M. E., van Veelen, Peter A., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Publicado 2023

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

por van der Lee, Dyantha I., Koutsoumpli, Georgia, Reijmers, Rogier M., Honders, M. Willy, de Jong, Rob C. M., Remst, Dennis F. G., Wachsmann, Tassilo L. A., Hagedoorn, Renate S., Franken, Kees L. M. C., Kester, Michel G. D., Harber, Karl J., Roelofsen, Lisanne M., Schouten, Annemiek M., Mulder, Arend, Drijfhout, Jan W., Veelken, Hendrik, van Veelen, Peter A., Heemskerk, Mirjam H. M., Falkenburg, J. H. Frederik, Griffioen, Marieke
Publicado 2021