A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent

por Pedersen, Lykke, Hagedorn, Peter H, Lindholm, Marie Wickström, Lindow, Morten
Publicado 2014

Managing the sequence-specificity of antisense oligonucleotides in drug discovery

por Hagedorn, Peter H., Hansen, Bo R., Koch, Troels, Lindow, Morten
Publicado 2017

RNase H sequence preferences influence antisense oligonucleotide efficiency

por Kiełpiński, Łukasz J., Hagedorn, Peter H., Lindow, Morten, Vinther, Jeppe
Publicado 2017

RNase H sequence preferences influence antisense oligonucleotide efficiency

por Kiełpiński, Łukasz J, Hagedorn, Peter H, Lindow, Morten, Vinther, Jeppe
Publicado 2019

Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers

por Kiełpiński, Łukasz J., Funder, Erik Daa, Schmidt, Steffen, Hagedorn, Peter H.
Publicado 2021

Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties

por Papargyri, Natalia, Pontoppidan, Malene, Andersen, Mikael R., Koch, Troels, Hagedorn, Peter H.
Publicado 2019

Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes

por Bang-Berthelsen, Claus H, Pedersen, Lykke, Fløyel, Tina, Hagedorn, Peter H, Gylvin, Titus, Pociot, Flemming
Publicado 2011

Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs

por Rukov, Jakob Lewin, Hagedorn, Peter H., Høy, Isabel Bro, Feng, Yanping, Lindow, Morten, Vinther, Jeppe
Publicado 2015

A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides

por Dieckmann, Andreas, Hagedorn, Peter H., Burki, Yvonne, Brügmann, Christine, Berrera, Marco, Ebeling, Martin, Singer, Thomas, Schuler, Franz
Publicado 2017

Long Noncoding RNA Expression during Human B-Cell Development

por Petri, Andreas, Dybkær, Karen, Bøgsted, Martin, Thrue, Charlotte Albæk, Hagedorn, Peter H., Schmitz, Alexander, Bødker, Julie Støve, Johnsen, Hans Erik, Kauppinen, Sakari
Publicado 2015

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

por Hagedorn, Peter H, Pontoppidan, Malene, Bisgaard, Tina S, Berrera, Marco, Dieckmann, Andreas, Ebeling, Martin, Møller, Marianne R, Hudlebusch, Heidi, Jensen, Marianne L, Hansen, Henrik F, Koch, Troels, Lindow, Morten
Publicado 2018

Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features

por Hagedorn, Peter H., Brown, Jeffrey M., Easton, Amy, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E., Mercer, Stephen E., Li, Dong, Loy, James, Høg, Anja M., Jensen, Marianne L., Gill, Martin, Cacace, Angela M.
Publicado 2022

Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides

por Anderson, Brian R., Jensen, Marianne L., Hagedorn, Peter H., Little, Sean C., Olson, Richard E., Ammar, Ron, Kienzle, Bernadette, Thompson, John, McDonald, Ivar, Mercer, Stephen, Vikesaa, Jonas, Nordbo, Bettina, Iben, Larry, Cao, Yang, Natale, Joanne, Dalton-Kay, Greg, Cacace, Angela, Hansen, Bo R., Hedtjärn, Maj, Koch, Troels, Bristow, Linda J.
Publicado 2020

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

por Easton, Amy, Jensen, Marianne L., Wang, Congwei, Hagedorn, Peter H., Li, Yuwen, Weed, Michael, Meredith, Jere E., Guss, Valerie, Jones, Kelli, Gill, Martin, Krause, Carol, Brown, Jeffrey M., Hunihan, Lisa, Natale, Joanne, Fernandes, Alda, Lu, Yifeng, Polino, Joe, Bookbinder, Mark, Cadelina, Greg, Benitex, Yulia, Sane, Ramola, Morrison, John, Drexler, Dieter, Mercer, Stephen E., Bon, Charlotte, Pandya, Nikhil J., Jagasia, Ravi, Ou Yang, Tai-Hsien, Distler, Tania, Grüninger, Fiona, Meldgaard, Michael, Terrigno, Marco, Macor, John E., Albright, Charles F., Loy, James, Hoeg, Anja M., Olson, Richard E., Cacace, Angela M.
Publicado 2022