Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

por Silva, M. Catarina, Haggarty, Stephen J.
Publicado 2020

SpectralNET – an application for spectral graph analysis and visualization

por Forman, Joshua J, Clemons, Paul A, Schreiber, Stuart L, Haggarty, Stephen J
Publicado 2005

Chemical Phylogenetics of Histone Deacetylases

por Bradner, James E., West, Nathan, Grachan, Melissa L., Greenberg, Edward F., Haggarty, Stephen J., Warnow, Tandy, Mazitschek, Ralph
Publicado 2010

HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells

por Iaconelli, Jonathan, Huang, Joanne H., Berkovitch, Shaunna S., Chattopadhyay, Shrikanta, Mazitschek, Ralph, Schreiber, Stuart L., Haggarty, Stephen J., Karmacharya, Rakesh
Publicado 2014

Identification of small molecules that Enhance Synaptogenesis using Synapse Microarrays

por Shi, Peng, Scott, Mark A, Ghosh, Balaram, Wan, Dongpeng, Wissner-Gross, Zachary, Mazitschek, Ralph, Haggarty, Stephen J., Yanik, Mehmet Fatih
Publicado 2011

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

por Sheridan, Steven D., Theriault, Kraig M., Reis, Surya A., Zhou, Fen, Madison, Jon M., Daheron, Laurence, Loring, Jeanne F., Haggarty, Stephen J.
Publicado 2011

An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration

por Petcherski, Anton, Chandrachud, Uma, Butz, Elisabeth S., Klein, Madeleine C., Zhao, Wen-Ning, Reis, Surya A., Haggarty, Stephen J., Ruonala, Mika O., Cotman, Susan L.
Publicado 2019

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

por Lalonde, Jasmin, Reis, Surya A., Sivakumaran, Sudhir, Holland, Carl S., Wesseling, Hendrik, Sauld, John F., Alural, Begum, Zhao, Wen-Ning, Steen, Judith A., Haggarty, Stephen J.
Publicado 2017

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

por Martin, Pauline, Wagh, Vilas, Reis, Surya A., Erdin, Serkan, Beauchamp, Roberta L., Shaikh, Ghalib, Talkowski, Michael, Thiele, Elizabeth, Sheridan, Steven D., Haggarty, Stephen J., Ramesh, Vijaya
Publicado 2020

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy

por Silva, M. Catarina, Nandi, Ghata, Donovan, Katherine A., Cai, Quan, Berry, Bethany C., Nowak, Radoslaw P., Fischer, Eric S., Gray, Nathanael S., Ferguson, Fleur M., Haggarty, Stephen J.
Publicado 2022

In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

por Wang, Changning, Schroeder, Frederick A., Wey, Hsiao-Ying, Borra, Ronald, Wagner, Florence F., Reis, Surya, Kim, Sung Won, Holson, Edward B., Haggarty, Stephen J., Hooker, Jacob M.
Publicado 2014

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

por Silva, M. Catarina, Nandi, Ghata A., Tentarelli, Sharon, Gurrell, Ian K., Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C., Brown, Dean G., Brandon, Nicholas J., Haggarty, Stephen J.
Publicado 2020

High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology

por Lin, Xudong, Duan, Xin, Jacobs, Claire, Ullmann, Jeremy, Chan, Chung-Yuen, Chen, Siya, Cheng, Shuk-Han, Zhao, Wen-Ning, Poduri, Annapurna, Wang, Xin, Haggarty, Stephen J., Shi, Peng
Publicado 2018

Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

por Poli, Valentina, Pui-Yan Ma, Victor, Di Gioia, Marco, Broggi, Achille, Benamar, Mehdi, Chen, Qian, Mazitschek, Ralph, Haggarty, Stephen J., Chatila, Talal A., Karp, Jeffrey M., Zanoni, Ivan
Publicado 2021

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

por Beauchamp, Roberta L., James, Marianne F., DeSouza, Patrick A., Wagh, Vilas, Zhao, Wen-Ning, Jordan, Justin T., Stemmer-Rachamimov, Anat, Plotkin, Scott R., Gusella, James F., Haggarty, Stephen J., Ramesh, Vijaya
Publicado 2015

HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination

por Strebl, Martin G., Campbell, Arthur J., Zhao, Wen-Ning, Schroeder, Frederick A., Riley, Misha M., Chindavong, Peter S., Morin, Thomas M., Haggarty, Stephen J., Wagner, Florence F., Ritter, Tobias, Hooker, Jacob M.
Publicado 2017

Rapid behavior—based identification of neuroactive small molecules in the zebrafish

por Kokel, David, Bryan, Jennifer, Laggner, Christian, White, Rick, Cheung, Chung Yan J., Mateus, Rita, Healey, David, Kim, Sonia, Werdich, Andreas A., Haggarty, Stephen J., MacRae, Calum A., Shoichet, Brian, Peterson, Randall T.
Publicado 2010

Dysregulation of miR-34a Links Neuronal Development to Genetic Risk Factors for Bipolar Disorder

por Bavamian, Sabine, Mellios, Nikolaos, Lalonde, Jasmin, Fass, Daniel M., Wang, Jennifer, Sheridan, Steven D., Madison, Jon M., Zhou, Fen, Rueckert, Erroll H., Barker, Doug, Perlis, Roy H., Sur, Mriganka, Haggarty, Stephen J.
Publicado 2015

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing

por Nguyen, Lien D., Wei, Zhiyun, Silva, M. Catarina, Barberán-Soler, Sergio, Zhang, Jiarui, Rabinovsky, Rosalia, Muratore, Christina R., Stricker, Jonathan M. S., Hortman, Colin, Young-Pearse, Tracy L., Haggarty, Stephen J., Krichevsky, Anna M.
Publicado 2023

Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes

por Reis, Surya A., Ghosh, Balaram, Hendricks, J. Adam, Szantai-Kis, D. Miklos, Törk, Lisa, Ross, Kenneth N., Lamb, Justin, Read-Button, Willis, Zheng, Baixue, Wang, Hongtao, Salthouse, Christopher, Haggarty, Stephen J., Mazitschek, Ralph
Publicado 2016