Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements

por Esposito, Maria Teresa, Hagström-Andersson, Anna, Stam, Ronald W., Bortoluzzi, Stefania
Publicado 2022

P479: TREATMENT IS SHAPING CLONAL EVOLUTION AND RESISTANCE PATTERNS IN MURINE KMT2A-REARRANGED LEUKEMIA WITH SUBCLONAL FLT3N676K

por Falqués-Costa, Ton, Pilheden, Mattias, Zhang, Qirui, Ahlgren, Louise, Sturesson, Helena, Rönnstrand, Lars, Hyrenius-Wittsten, Axel, Kazi, Julhash U., Hagström-Andersson, Anna K.
Publicado 2023

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance

por Åbacka, Hannah, Hansen, Jesper S., Huang, Peng, Venskutonytė, Raminta, Hyrenius-Wittsten, Axel, Poli, Giulio, Tuccinardi, Tiziano, Granchi, Carlotta, Minutolo, Filippo, Hagström-Andersson, Anna K., Lindkvist-Petersson, Karin
Publicado 2021

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

por Chapellier, Marion, Peña-Martínez, Pablo, Ramakrishnan, Ramprasad, Eriksson, Mia, Talkhoncheh, Mehrnaz Safaee, Orsmark-Pietras, Christina, Lilljebjörn, Henrik, Högberg, Carl, Hagström-Andersson, Anna, Fioretos, Thoas, Larsson, Jonas, Järås, Marcus
Publicado 2019

FLT3(N676K) drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis

por Hyrenius-Wittsten, Axel, Pilheden, Mattias, Falqués-Costa, Antoni, Eriksson, Mia, Sturesson, Helena, Schneider, Pauline, Wander, Priscilla, Garcia-Ruiz, Cristian, Liu, Jian, Ågerstam, Helena, Hultquist, Anne, Lilljebjörn, Henrik, Stam, Ronald W., Järås, Marcus, Hagström-Andersson, Anna K.
Publicado 2019

CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

por Ramakrishnan, Ramprasad, Peña-Martínez, Pablo, Agarwal, Puneet, Rodriguez-Zabala, Maria, Chapellier, Marion, Högberg, Carl, Eriksson, Mia, Yudovich, David, Shah, Mansi, Ehinger, Mats, Nilsson, Björn, Larsson, Jonas, Hagström-Andersson, Anna, Ebert, Benjamin L., Bhatia, Ravi, Järås, Marcus
Publicado 2020

Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

por Rodriguez-Zabala, Maria, Ramakrishnan, Ramprasad, Reinbach, Katrin, Ghosh, Somadri, Oburoglu, Leal, Falqués-Costa, Antoni, Bellamkonda, Kishan, Ehinger, Mats, Peña-Martínez, Pablo, Puente-Moncada, Noelia, Lilljebjörn, Henrik, Cammenga, Jörg, Pronk, Cornelis Jan, Lazarevic, Vladimir, Fioretos, Thoas, Hagström-Andersson, Anna K., Woods, Niels-Bjarne, Järås, Marcus
Publicado 2023

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

por Hyrenius-Wittsten, Axel, Pilheden, Mattias, Sturesson, Helena, Hansson, Jenny, Walsh, Michael P., Song, Guangchun, Kazi, Julhash U., Liu, Jian, Ramakrishan, Ramprasad, Garcia-Ruiz, Cristian, Nance, Stephanie, Gupta, Pankaj, Zhang, Jinghui, Rönnstrand, Lars, Hultquist, Anne, Downing, James R., Lindkvist-Petersson, Karin, Paulsson, Kajsa, Järås, Marcus, Gruber, Tanja A., Ma, Jing, Hagström-Andersson, Anna K.
Publicado 2018

Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia

por Pilheden, Mattias, Ahlgren, Louise, Hyrenius-Wittsten, Axel, Gonzalez-Pena, Veronica, Sturesson, Helena, Hansen Marquart, Hanne Vibeke, Lausen, Birgitte, Castor, Anders, Pronk, Cornelis Jan, Barbany, Gisela, Pokrovskaja Tamm, Katja, Fogelstrand, Linda, Lohi, Olli, Norén-Nyström, Ulrika, Asklin, Johanna, Chen, Yilun, Song, Guangchun, Walsh, Michael, Ma, Jing, Zhang, Jinghui, Saal, Lao H., Gawad, Charles, Hagström-Andersson, Anna K.
Publicado 2022