In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome

por Haify, Saif N., Botta-Orfila, Teresa, Hukema, Renate K., Tartaglia, Gian Gaetano
Publicado 2020

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

por Haify, Saif N., Mankoe, Ruchira S. D., Boumeester, Valerie, van der Toorn, Esmay C., Verhagen, Rob F. M., Willemsen, Rob, Hukema, Renate K., Bosman, Laurens W. J.
Publicado 2020

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation

por Haify, Saif N, Buijsen, Ronald A M, Verwegen, Lucas, Severijnen, Lies-Anne W F M, de Boer, Helen, Boumeester, Valerie, Monshouwer, Roos, Yang, Wang-Yong, Cameron, Michael D, Willemsen, Rob, Disney, Matthew D, Hukema, Renate K
Publicado 2021

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pa...

por Wenzel, H. Jürgen, Murray, Karl D., Haify, Saif N., Hunsaker, Michael R., Schwartzer, Jared J., Kim, Kyoungmi, La Spada, Albert R., Sopher, Bryce L., Hagerman, Paul J., Raske, Christopher, Severijnen, Lies-Anne W.F.M., Willemsen, Rob, Hukema, Renate K., Berman, Robert F.
Publicado 2019

Neuropathology of FMR1-premutation carriers presenting with dementia and neuropsychiatric symptoms

por Dijkstra, Anke A, Haify, Saif N, Verwey, Niek A, Prins, Niels D, van der Toorn, Esmay C, Rozemuller, Annemieke J M, Bugiani, Marianna, den Dunnen, Wilfred F A, Todd, Peter K, Charlet-Berguerand, Nicolas, Willemsen, Rob, Hukema, Renate K, Hoozemans, Jeroen J M
Publicado 2021