Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots

por Foliaki, Simote T., Haigh, Cathryn L.
Publicado 2023

Endoproteolytic cleavage as a molecular switch regulating and diversifying prion protein function

por Haigh, Cathryn L., Collins, Steven J.
Publicado 2016

Using our mini-brains: cerebral organoids as an improved cellular model for human prion disease

por Groveman, Bradley R., Walters, Ryan, Haigh, Cathryn L.
Publicado 2019

Cytosolic caspases mediate mislocalised SOD2 depletion in an in vitro model of chronic prion infection

por Sinclair, Layla, Lewis, Victoria, Collins, Steven J., Haigh, Cathryn L.
Publicado 2013

Cerebral organoids as a new model for prion disease

por Groveman, Bradley R., Smith, Anna, Williams, Katie, Haigh, Cathryn L.
Publicado 2021

The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses

por Haigh, Cathryn L., Tumpach, Carolin, Drew, Simon C., Collins, Steven J.
Publicado 2015

Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression

por Collins, Steven J., Tumpach, Carolin, Groveman, Bradley R., Drew, Simon C., Haigh, Cathryn L.
Publicado 2018

Reduced SOD2 expression does not influence prion disease course or pathology in mice

por Foliaki, Simote T., Race, Brent, Williams, Katie, Baune, Chase, Groveman, Bradley R., Haigh, Cathryn L.
Publicado 2021

Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model

por Williams, Katie, Foliaki, Simote T., Race, Brent, Smith, Anna, Thomas, Tina, Groveman, Bradley R., Haigh, Cathryn L.
Publicado 2023

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP(res )level disparity

por Lewis, Victoria, Haigh, Cathryn L, Masters, Colin L, Hill, Andrew F, Lawson, Victoria A, Collins, Steven J
Publicado 2012

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

por Groveman, Bradley R., Foliaki, Simote T., Orru, Christina D., Zanusso, Gianluigi, Carroll, James A., Race, Brent, Haigh, Cathryn L.
Publicado 2019

Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease

por Foliaki, Simote T., Groveman, Bradley R., Yuan, Jue, Walters, Ryan, Zhang, Shulin, Tesar, Paul, Zou, Wenquan, Haigh, Cathryn L.
Publicado 2020

Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein

por Foliaki, Simote T., Wood, Aleksandar, Williams, Katie, Smith, Anna, Walters, Ryan O., Baune, Chase, Groveman, Bradley R., Haigh, Cathryn L.
Publicado 2023

Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice

por Groveman, Bradley R., Race, Brent, Foliaki, Simote T., Williams, Katie, Hughson, Andrew G., Baune, Chase, Zanusso, Gianluigi, Haigh, Cathryn L.
Publicado 2023

A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways

por Groveman, Bradley R., Schwarz, Benjamin, Bohrnsen, Eric, Foliaki, Simote T., Carroll, James A., Wood, Aleksandar R., Bosio, Catharine M., Haigh, Cathryn L.
Publicado 2023

Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function

por Wood, Aleksandar R., Foliaki, Simote T., Groveman, Bradley R., Walters, Ryan O., Williams, Katie, Yuan, Jue, Zou, Wen-Quan, Haigh, Cathryn L.
Publicado 2022

Stress and viral insults do not trigger E200K PrP conversion in human cerebral organoids

por Smith, Anna, Groveman, Bradley R., Winkler, Clayton, Williams, Katie, Walters, Ryan, Yuan, Jue, Zou, Wenquan, Peterson, Karin, Foliaki, Simote T., Haigh, Cathryn L.
Publicado 2022

The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

por Collins, Steven J, Tumpach, Carolin, Li, Qiao-Xin, Lewis, Victoria, Ryan, Timothy M, Roberts, Blaine, Drew, Simon C, Lawson, Victoria A, Haigh, Cathryn L
Publicado 2015

Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease

por Groveman, Bradley R., Ferreira, Natalia C., Foliaki, Simote T., Walters, Ryan O., Winkler, Clayton W., Race, Brent, Hughson, Andrew G., Zanusso, Gianluigi, Haigh, Cathryn L.
Publicado 2021

Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction

por Foliaki, Simote T., Smith, Anna, Schwarz, Benjamin, Bohrnsen, Eric, Bosio, Catharine M., Williams, Katie, Orrú, Christina D., Lachenauer, Hailey, Groveman, Bradley R., Haigh, Cathryn L.
Publicado 2023