No back seat for a progression event—K-RAS as a therapeutic target in CRC

por Poulin, Emily J., Haigis, Kevin M.
Publicado 2017

Computational translation of genomic responses from experimental model systems to humans

por Brubaker, Douglas K., Proctor, Elizabeth A., Haigis, Kevin M., Lauffenburger, Douglas A.
Publicado 2019

BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner

por Lau, Ken S., Zhang, Tinghu, Kendall, Krystle R., Lauffenburger, Douglas, Gray, Nathanael S., Haigis, Kevin M.
Publicado 2012

Comparative Analysis of Radiosensitizers for K-RAS Mutant Rectal Cancers

por Kleiman, Laura B., Krebs, Angela M., Kim, Stephen Y., Hong, Theodore S., Haigis, Kevin M.
Publicado 2013

The origins and genetic interactions of KRAS mutations are allele- and tissue-specific

por Cook, Joshua H., Melloni, Giorgio E. M., Gulhan, Doga C., Park, Peter J., Haigis, Kevin M.
Publicado 2021

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium

por Lau, Ken S., Cortez-Retamozo, Virna, Philips, Sarah R., Pittet, Mikael J., Lauffenburger, Douglas A., Haigis, Kevin M.
Publicado 2012

Correction: Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium

por Lau, Ken S., Cortez-Retamozo, Virna, Philips, Sarah R., Pittet, Mikael J., Lauffenburger, Douglas A., Haigis, Kevin M.
Publicado 2012

Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation

por Cho, Hansang, Hashimoto, Tadafumi, Wong, Elisabeth, Hori, Yukiko, Wood, Levi B., Zhao, Lingzhi, Haigis, Kevin M., Hyman, Bradley T., Irimia, Daniel
Publicado 2013

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

por Suarez-Lopez, Lucia, Kong, Yi Wen, Sriram, Ganapathy, Patterson, Jesse C., Rosenberg, Samantha, Morandell, Sandra, Haigis, Kevin M., Yaffe, Michael B.
Publicado 2021

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation

por Suarez-Lopez, Lucia, Shui, Bing, Brubaker, Douglas K., Hill, Marza, Bergendorf, Alexander, Changelian, Paul S., Laguna, Aisha, Starchenko, Alina, Lauffenburger, Douglas A., Haigis, Kevin M.
Publicado 2021

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

por Wood, Levi B., Winslow, Ashley R., Proctor, Elizabeth A., McGuone, Declan, Mordes, Daniel A., Frosch, Matthew P., Hyman, Bradley T., Lauffenburger, Douglas A., Haigis, Kevin M.
Publicado 2015

Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

por Johnson, Christian W., Lin, Yi-Jang, Reid, Derion, Parker, Jillian, Pavlopoulos, Spiro, Dischinger, Patrick, Graveel, Carrie, Aguirre, Andrew J., Steensma, Matthew, Haigis, Kevin M., Mattos, Carla
Publicado 2019

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

por Lyons, Jesse, Ghazi, Phaedra C., Starchenko, Alina, Tovaglieri, Alessio, Baldwin, Katherine R., Poulin, Emily J., Gierut, Jessica J., Genetti, Casie, Yajnik, Vijay, Breault, David T., Lauffenburger, Douglas A., Haigis, Kevin M.
Publicado 2018

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

por Nicolay, Brandon N., Danielian, Paul S., Kottakis, Filippos, Lapek, John D., Sanidas, Ioannis, Miles, Wayne O., Dehnad, Mantre, Tschöp, Katrin, Gierut, Jessica J., Manning, Amity L., Morris, Robert, Haigis, Kevin, Bardeesy, Nabeel, Lees, Jacqueline A., Haas, Wilhelm, Dyson, Nicholas J.
Publicado 2015

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

por Imamura, Yu, Lochhead, Paul, Yamauchi, Mai, Kuchiba, Aya, Qian, Zhi Rong, Liao, Xiaoyun, Nishihara, Reiko, Jung, Seungyoun, Wu, Kana, Nosho, Katsuhiko, Wang, Yaoyu E, Peng, Shouyong, Bass, Adam J, Haigis, Kevin M, Meyerhardt, Jeffrey A, Chan, Andrew T, Fuchs, Charles S, Ogino, Shuji
Publicado 2014

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

por La Rocca, Gaspare, King, Bryan, Shui, Bing, Li, Xiaoyi, Zhang, Minsi, Akat, Kemal M, Ogrodowski, Paul, Mastroleo, Chiara, Chen, Kevin, Cavalieri, Vincenzo, Ma, Yilun, Anelli, Viviana, Betel, Doron, Vidigal, Joana, Tuschl, Thomas, Meister, Gunter, Thompson, Craig B, Lindsten, Tullia, Haigis, Kevin, Ventura, Andrea
Publicado 2021

A UV-independent pathway to melanoma carcinogenesis in the redhair-fairskin background

por Mitra, Devarati, Luo, Xi, Morgan, Ann, Wang, Jin, Hoang, Mai P., Lo, Jennifer, Guerrero, Candace R., Lennerz, Jochen K., Mihm, Martin C., Wargo, Jennifer A., Robinson, Kathleen C., Devi, Suprabha P., Vanover, Jillian C., D’Orazio, John A., McMahon, Martin, Bosenberg, Marcus W., Haigis, Kevin M., Haber, Daniel A., Wang, Yinsheng, Fisher, David E.
Publicado 2012

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

por Kaiser, Sergio, Park, Young-Kyu, Franklin, Jeffrey L, Halberg, Richard B, Yu, Ming, Jessen, Walter J, Freudenberg, Johannes, Chen, Xiaodi, Haigis, Kevin, Jegga, Anil G, Kong, Sue, Sakthivel, Bhuvaneswari, Xu, Huan, Reichling, Timothy, Azhar, Mohammad, Boivin, Gregory P, Roberts, Reade B, Bissahoyo, Anika C, Gonzales, Fausto, Bloom, Greg C, Eschrich, Steven, Carter, Scott L, Aronow, Jeremy E, Kleimeyer, John, Kleimeyer, Michael, Ramaswamy, Vivek, Settle, Stephen H, Boone, Braden, Levy, Shawn, Graff, Jonathan M, Doetschman, Thomas, Groden, Joanna, Dove, William F, Threadgill, David W, Yeatman, Timothy J, Coffey, Robert J, Aronow, Bruce J
Publicado 2007

Discovery of a selective inhibitor of Doublecortin Like Kinase 1

por Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.
Publicado 2020