Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress

por Hains, Avis Brennan, Yabe, Yoko, Arnsten, Amy F.T.
Publicado 2015

First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers

por Tang, Fei, Kunder, Rebecca, Chu, Tom, Hains, Avis, Nguyen, Allen, McBride, Jacqueline M., Zhong, Yu, Santagostino, Sara, Wilson, Maria, Trenchak, Abigail, Chen, Liuxi, Ly, Justin, Moein, Anita, Lewin‐Koh, Nicholas, Raghavan, Vibha, Osaghae, Uyi, Wynne, Chris, Owen, Ryan, Place, David
Publicado 2023

A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS

por Katz, Jonathan S., Rothstein, Jeffrey D., Cudkowicz, Merit E., Genge, Angela, Oskarsson, Björn, Hains, Avis B., Chen, Chen, Galanter, Joshua, Burgess, Braydon L., Cho, William, Kerchner, Geoffrey A., Yeh, Felix L., Ghosh, Arundhati Sengupta, Cheeti, Sravanthi, Brooks, Logan, Honigberg, Lee, Couch, Jessica A., Rothenberg, Michael E., Brunstein, Flavia, Sharma, Khema R., van den Berg, Leonard, Berry, James D., Glass, Jonathan D.
Publicado 2022