Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder

por Salmena, Leonardo, Hakem, Razqallah
Publicado 2005

From photomorphogenesis to cancer: A CSN journey

por Salmena, Leonardo, Hakem, Razqallah
Publicado 2013

DNA double-strand break signaling and human disorders

por Bohgaki, Toshiyuki, Bohgaki, Miyuki, Hakem, Razqallah
Publicado 2010

BRCA1 and Metastasis: Outcome of Defective DNA Repair

por Krishnan, Rehna, Patel, Parasvi S., Hakem, Razqallah
Publicado 2021

Genome Integrity - a new open access journal

por Hakem, Razqallah, Hande, M Prakash, Petrini, John, Slijepcevic, Predrag
Publicado 2010

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim(−/−) mice

por Bohgaki, Toshiyuki, Mozo, Julien, Salmena, Leonardo, Matysiak-Zablocki, Elzbieta, Bohgaki, Miyuki, Sanchez, Otto, Strasser, Andreas, Hakem, Anne, Hakem, Razqallah
Publicado 2011

Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis

por Halaby, Marie-Jo, Hakem, Anne, Li, Li, El Ghamrasni, Samah, Venkatesan, Shriram, Hande, Prakash M., Sanchez, Otto, Hakem, Razqallah
Publicado 2013

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

por Kaiser, William J., Upton, Jason W., Long, Alyssa B., Livingston-Rosanoff, Devon, Daley, Lisa P., Hakem, Razqallah, Caspary, Tamara, Mocarski, Edward S.
Publicado 2011

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

por Li, Li, Halaby, Marie-Jo, Hakem, Anne, Cardoso, Renato, El Ghamrasni, Samah, Harding, Shane, Chan, Norman, Bristow, Robert, Sanchez, Otto, Durocher, Daniel, Hakem, Razqallah
Publicado 2010

Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome

por Bohgaki, Toshiyuki, Bohgaki, Miyuki, Cardoso, Renato, Panier, Stephanie, Zeegers, Dimphy, Li, Li, Stewart, Grant S., Sanchez, Otto, Hande, M. Prakash, Durocher, Daniel, Hakem, Anne, Hakem, Razqallah
Publicado 2011

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

por Jones, Russell G., Elford, Alisha R., Parsons, Michael J., Wu, Linda, Krawczyk, Connie M., Yeh, Wen-Chen, Hakem, Razqallah, Rottapel, Robert, Woodgett, James R., Ohashi, Pamela S.
Publicado 2002

Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer

por El Ghamrasni, Samah, Pamidi, Ashwin, Halaby, Marie Jo, Bohgaki, Miyuki, Cardoso, Renato, Li, Li, Venkatesan, Shriram, Sethu, Swaminathan, Hirao, Atsushi, Mak, Tak W., Hande, Manoor Prakash, Hakem, Anne, Hakem, Razqallah
Publicado 2011

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

por Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah
Publicado 2016

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

por Krajewska, Maryla, You, Zerong, Rong, Juan, Kress, Christina, Huang, Xianshu, Yang, Jinsheng, Kyoda, Tiffany, Leyva, Ricardo, Banares, Steven, Hu, Yue, Sze, Chia-Hung, Whalen, Michael J., Salmena, Leonardo, Hakem, Razqallah, Head, Brian P., Reed, John C., Krajewski, Stan
Publicado 2011

Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

por Patel, Parasvi S, Algouneh, Arash, Krishnan, Rehna, Reynolds, John J, Nixon, Kevin C J, Hao, Jun, Lee, Jihoon, Feng, Yue, Fozil, Chehronai, Stanic, Mia, Yerlici, Talya, Su, Peiran, Soares, Fraser, Liedtke, Elisabeth, Prive, Gil, Baider, Gary D, Pujana, Miquel Angel, Mekhail, Karim, He, Housheng Hansen, Hakem, Anne, Stewart, Grant S, Hakem, Razqallah
Publicado 2023

Systemic ceramide accumulation leads to severe and varied pathological consequences

por Alayoubi, Abdulfatah M, Wang, James C M, Au, Bryan C Y, Carpentier, Stéphane, Garcia, Virginie, Dworski, Shaalee, El-Ghamrasni, Samah, Kirouac, Kevin N, Exertier, Mathilde J, Xiong, Zi Jian, Privé, Gilbert G, Simonaro, Calogera M, Casas, Josefina, Fabrias, Gemma, Schuchman, Edward H, Turner, Patricia V, Hakem, Razqallah, Levade, Thierry, Medin, Jeffrey A
Publicado 2013

IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells

por Nachmias, Boaz, Khan, Dilshad H., Voisin, Veronique, Mer, Arvind S., Thomas, Geethu Emily, Segev, Nadav, St-Germain, Jonathan, Hurren, Rose, Gronda, Marcela, Botham, Aaron, Wang, Xiaoming, Maclean, Neil, Seneviratne, Ayesh K., Duong, Nathan, Xu, Changjiang, Arruda, Andrea, Orouji, Elias, Algouneh, Arash, Hakem, Razqallah, Shlush, Liran, Minden, Mark D., Raught, Brian, Bader, Gary D., Schimmer, Aaron D.
Publicado 2022

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

por Hakem, Anne, Bohgaki, Miyuki, Lemmers, Bénédicte, Tai, Elisabeth, Salmena, Leonardo, Matysiak-Zablocki, Elzbieta, Jung, Yong-Sam, Karaskova, Jana, Kaustov, Lilia, Duan, Shili, Madore, Jason, Boutros, Paul, Sheng, Yi, Chesi, Marta, Bergsagel, P. Leif, Perez-Ordonez, Bayardo, Mes-Masson, Anne-Marie, Penn, Linda, Squire, Jeremy, Chen, Xinbin, Jurisica, Igor, Arrowsmith, Cheryl, Sanchez, Otto, Benchimol, Samuel, Hakem, Razqallah
Publicado 2011

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

por Krishnan, Rehna, Lapierre, Mariah, Gautreau, Brandon, Nixon, Kevin C J, El Ghamrasni, Samah, Patel, Parasvi S, Hao, Jun, Yerlici, V Talya, Guturi, Kiran Kumar Naidu, St-Germain, Jonathan, Mateo, Francesca, Saad, Amine, Algouneh, Arash, Earnshaw, Rebecca, Shili, Duan, Seitova, Alma, Miller, Joshua, Khosraviani, Negin, Penn, Adam, Ho, Brandon, Sanchez, Otto, Hande, M Prakash, Masson, Jean-Yves, Brown, Grant W, Alaoui-Jamali, Moulay, Reynolds, John J, Arrowsmith, Cheryl, Raught, Brian, Pujana, Miguel A, Mekhail, Karim, Stewart, Grant S, Hakem, Anne, Hakem, Razqallah
Publicado 2023