Barriers and opportunities for gemcitabine in pancreatic cancer therapy

por Beutel, Alica K., Halbrook, Christopher J.
Publicado 2023

Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis

por Halbrook, Christopher J., Wen, Hui-Ju, Ruggeri, Jeanine M., Takeuchi, Kenneth K., Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C.
Publicado 2016

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

por Schofield, Heather K., Tandon, Manuj, Park, Min-Jung, Halbrook, Christopher J., Ramakrishnan, Sadeesh K., Kim, Esther C., Shi, Jiaqi, Omary, M. Bishr, Shah, Yatrik M., Esni, Farzad, Pasca di Magliano, Marina
Publicado 2017

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway

por Boyer, Seth, Lee, Ho-Joon, Steele, Nina, Zhang, Li, Sajjakulnukit, Peter, Andren, Anthony, Ward, Matthew H, Singh, Rima, Basrur, Venkatesha, Zhang, Yaqing, Nesvizhskii, Alexey I, Pasca di Magliano, Marina, Halbrook, Christopher J, Lyssiotis, Costas A
Publicado 2022

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis

por Wang, Lidong, Yang, Huibin, Zamperone, Andrea, Diolaiti, Daniel, Palmbos, Phillip L., Abel, Ethan V., Purohit, Vinee, Dolgalev, Igor, Rhim, Andrew D., Ljungman, Mats, Hadju, Christina H., Halbrook, Christopher J., Bar-Sagi, Dafna, di Magliano, Marina Pasca, Crawford, Howard C., Simeone, Diane M.
Publicado 2019

PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance

por Roy, Nilotpal, Takeuchi, Kenneth K., Ruggeri, Jeanine M., Bailey, Peter, Chang, David, Li, Joey, Leonhardt, Laura, Puri, Sapna, Hoffman, Megan T., Gao, Shan, Halbrook, Christopher J., Song, Yan, Ljungman, Mats, Malik, Shivani, Wright, Christopher V.E., Dawson, David W., Biankin, Andrew V., Hebrok, Matthias, Crawford, Howard C.
Publicado 2016

Arginase 1 is a key driver of immune suppression in pancreatic cancer

por Menjivar, Rosa E, Nwosu, Zeribe C, Du, Wenting, Donahue, Katelyn L, Hong, Hanna S, Espinoza, Carlos, Brown, Kristee, Velez-Delgado, Ashley, Yan, Wei, Lima, Fatima, Bischoff, Allison, Kadiyala, Padma, Salas-Escabillas, Daniel, Crawford, Howard C, Bednar, Filip, Carpenter, Eileen, Zhang, Yaqing, Halbrook, Christopher J, Lyssiotis, Costas A, Pasca di Magliano, Marina
Publicado 2023

Hyaluronic acid fuels pancreatic cancer cell growth

por Kim, Peter K, Halbrook, Christopher J, Kerk, Samuel A, Radyk, Megan, Wisner, Stephanie, Kremer, Daniel M, Sajjakulnukit, Peter, Andren, Anthony, Hou, Sean W, Trivedi, Ayush, Thurston, Galloway, Anand, Abhinav, Yan, Liang, Salamanca-Cardona, Lucia, Welling, Samuel D, Zhang, Li, Pratt, Matthew R, Keshari, Kayvan R, Ying, Haoqiang, Lyssiotis, Costas A
Publicado 2021

Mutant p53(R270H) drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma

por Schofield, Heather K., Zeller, Jörg, Espinoza, Carlos, Halbrook, Christopher J., del Vecchio, Annachiara, Magnuson, Brian, Fabo, Tania, Daylan, Ayse Ece Cali, Kovalenko, Ilya, Lee, Ho-Joon, Yan, Wei, Feng, Ying, Karim, Saadia A., Kremer, Daniel M., Kumar-Sinha, Chandan, Lyssiotis, Costas A., Ljungman, Mats, Morton, Jennifer P., Galbán, Stefanie, Fearon, Eric R., Pasca di Magliano, Marina
Publicado 2018

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

por Nelson, Barbara S., Lin, Lin, Kremer, Daniel M., Sousa, Cristovão M., Cotta-Ramusino, Cecilia, Myers, Amy, Ramos, Johanna, Gao, Tina, Kovalenko, Ilya, Wilder-Romans, Kari, Dresser, Joseph, Davis, Mary, Lee, Ho-Joon, Nwosu, Zeribe C., Campit, Scott, Mashadova, Oksana, Nicolay, Brandon N., Tolstyka, Zachary P., Halbrook, Christopher J., Chandrasekaran, Sriram, Asara, John M., Crawford, Howard C., Cantley, Lewis C., Kimmelman, Alec C., Wahl, Daniel R., Lyssiotis, Costas A.
Publicado 2020

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

por Nwosu, Zeribe C., Ward, Matthew H., Sajjakulnukit, Peter, Poudel, Pawan, Ragulan, Chanthirika, Kasperek, Steven, Radyk, Megan, Sutton, Damien, Menjivar, Rosa E., Andren, Anthony, Apiz-Saab, Juan J., Tolstyka, Zachary, Brown, Kristee, Lee, Ho-Joon, Dzierozynski, Lindsey N., He, Xi, PS, Hari, Ugras, Julia, Nyamundanda, Gift, Zhang, Li, Halbrook, Christopher J., Carpenter, Eileen S., Shi, Jiaqi, Shriver, Leah P., Patti, Gary J., Muir, Alexander, Pasca di Magliano, Marina, Sadanandam, Anguraj, Lyssiotis, Costas A.
Publicado 2023

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

por Zhou, Weihua, Yao, Yangyang, Scott, Andrew J., Wilder-Romans, Kari, Dresser, Joseph J., Werner, Christian K., Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zhao, Shuang G., Davis, Mary, Nelson, Barbara S., Halbrook, Christopher J., Zhang, Li, Gatto, Francesco, Umemura, Yoshie, Walker, Angela K., Kachman, Maureen, Sarkaria, Jann N., Xiong, Jianping, Morgan, Meredith A., Rehemtualla, Alnawaz, Castro, Maria G., Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore S., Lyssiotis, Costas A., Wahl, Daniel R.
Publicado 2020

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

por Kerk, Samuel A, Lin, Lin, Myers, Amy L, Sutton, Damien J, Andren, Anthony, Sajjakulnukit, Peter, Zhang, Li, Zhang, Yaqing, Jiménez, Jennifer A, Nelson, Barbara S, Chen, Brandon, Robinson, Anthony, Thurston, Galloway, Kemp, Samantha B, Steele, Nina G, Hoffman, Megan T, Wen, Hui-Ju, Long, Daniel, Ackenhusen, Sarah E, Ramos, Johanna, Gao, Xiaohua, Nwosu, Zeribe C, Galban, Stefanie, Halbrook, Christopher J, Lombard, David B, Piwnica-Worms, David R, Ying, Haoqiang, Pasca di Magliano, Marina, Crawford, Howard C, Shah, Yatrik M, Lyssiotis, Costas A
Publicado 2022

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

por Halbrook, Christopher J., Thurston, Galloway, Boyer, Seth, Anaraki, Cecily, Jiménez, Jennifer A., McCarthy, Amy, Steele, Nina G., Kerk, Samuel A., Hong, Hanna S., Lin, Lin, Law, Fiona V., Felton, Catherine, Scipioni, Lorenzo, Sajjakulnukit, Peter, Andren, Anthony, Beutel, Alica K., Singh, Rima, Nelson, Barbara S., Van Den Bergh, Fran, Krall, Abigail S., Mullen, Peter J., Zhang, Li, Batra, Sandeep, Morton, Jennifer P., Stanger, Ben Z., Christofk, Heather R., Digman, Michelle A., Beard, Daniel A., Viale, Andrea, Zhang, Ji, Crawford, Howard C., Pasca di Magliano, Marina, Jorgensen, Claus, Lyssiotis, Costas A.
Publicado 2022

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

por Kremer, Daniel M., Nelson, Barbara S., Lin, Lin, Yarosz, Emily L., Halbrook, Christopher J., Kerk, Samuel A., Sajjakulnukit, Peter, Myers, Amy, Thurston, Galloway, Hou, Sean W., Carpenter, Eileen S., Andren, Anthony C., Nwosu, Zeribe C., Cusmano, Nicholas, Wisner, Stephanie, Mbah, Nneka E., Shan, Mengrou, Das, Nupur K., Magnuson, Brian, Little, Andrew C., Savani, Milan R., Ramos, Johanna, Gao, Tina, Sastra, Stephen A., Palermo, Carmine F., Badgley, Michael A., Zhang, Li, Asara, John M., McBrayer, Samuel K., di Magliano, Marina Pasca, Crawford, Howard C., Shah, Yatrik M., Olive, Kenneth P., Lyssiotis, Costas A.
Publicado 2021