How to Culture, Record and Stimulate Neuronal Networks on Micro-electrode Arrays (MEAs)

por Hales, Chadwick M., Rolston, John D., Potter, Steve M.
Publicado 2010

Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson’s Disease

por Tandra, Gabriella, Yoone, Amy, Mathew, Rhea, Wang, Minzhi, Hales, Chadwick M., Mitchell, Cassie S.
Publicado 2023

Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays

por Hales, Chadwick M., Zeller-Townson, Riley, Newman, Jonathan P., Shoemaker, James T., Killian, Nathan J., Potter, Steve M.
Publicado 2012

Integrated Approaches for Analyzing U1-70K Cleavage in Alzheimer’s Disease

por Bai, Bing, Chen, Ping-Chung, Hales, Chadwick M., Wu, Zhiping, Pagala, Vishwajeeth, High, Anthony A., Levey, Allan I., Lah, James J., Peng, Junmin
Publicado 2014

TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration

por Lee, Samuel M, Asress, Seneshaw, Hales, Chadwick M, Gearing, Marla, Vizcarra, Juan C, Fournier, Christina N, Gutman, David A, Chin, Lih-Shen, Li, Lian, Glass, Jonathan D
Publicado 2019

Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism

por Borkowski, Kamil, Seyfried, Nicholas T., Arnold, Matthias, Lah, James J., Levey, Allan I., Hales, Chadwick M., Dammer, Eric B., Blach, Colette, Louie, Gregory, Kaddurah-Daouk, Rima, Newman, John W.
Publicado 2023

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

por Hales, Chadwick M, Seyfried, Nicholas T, Dammer, Eric B, Duong, Duc, Yi, Hong, Gearing, Marla, Troncoso, Juan C, Mufson, Elliott J, Thambisetty, Madhav, Levey, Allan I, Lah, James J
Publicado 2014

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

por Preininger, Marcela K., Jha, Rajneesh, Maxwell, Joshua T., Wu, Qingling, Singh, Monalisa, Wang, Bo, Dalal, Aarti, Mceachin, Zachary T., Rossoll, Wilfried, Hales, Chadwick M., Fischbach, Peter S., Wagner, Mary B., Xu, Chunhui
Publicado 2016

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

por Borkowski, Kamil, Pedersen, Theresa L., Seyfried, Nicholas T., Lah, James J., Levey, Allan I., Hales, Chadwick M., Dammer, Eric B., Blach, Colette, Louie, Gregory, Kaddurah-Daouk, Rima, Newman, John W.
Publicado 2021

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

por Holler, Christopher J., Taylor, Georgia, McEachin, Zachary T., Deng, Qiudong, Watkins, William J., Hudson, Kathryn, Easley, Charles A., Hu, William T., Hales, Chadwick M., Rossoll, Wilfried, Bassell, Gary J., Kukar, Thomas
Publicado 2016

5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease

por Kuehner, Janise N., Chen, Junyu, Bruggeman, Emily C., Wang, Feng, Li, Yangping, Xu, Chongchong, McEachin, Zachary T., Li, Ziyi, Chen, Li, Hales, Chadwick M., Wen, Zhexing, Yang, Jingjing, Yao, Bing
Publicado 2021

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

por Rangaraju, Srikant, Dammer, Eric B., Raza, Syed Ali, Gao, Tianwen, Xiao, Hailian, Betarbet, Ranjita, Duong, Duc M., Webster, James A., Hales, Chadwick M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Publicado 2018

CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease

por Hu, William T., Watts, Kelly D., Tailor, Prashant, Nguyen, Trung P., Howell, Jennifer C., Lee, Raven C., Seyfried, Nicholas T., Gearing, Marla, Hales, Chadwick M., Levey, Allan I., Lah, James J., Lee, Eva K.
Publicado 2016

A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy

por Gutierrez-Quiceno, Laura, Dammer, Eric B., Johnson, Ashlyn Grace, Webster, James A., Shah, Rhythm, Duong, Duc, Yin, Luming, Seyfried, Nicholas T., Alvarez, Victor E., Stein, Thor D., McKee, Ann C., Hales, Chadwick M.
Publicado 2021

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients

por Konrad, Csaba, Kawamata, Hibiki, Bredvik, Kirsten G., Arreguin, Andrea J., Cajamarca, Steven A., Hupf, Jonathan C., Ravits, John M., Miller, Timothy M., Maragakis, Nicholas J., Hales, Chadwick M., Glass, Jonathan D., Gross, Steven, Mitsumoto, Hiroshi, Manfredi, Giovanni
Publicado 2017

The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias

por Bender, Alexis A., McIntosh, Rebecca L., Sudduth, Sean, Harris, Michaela, Tuckey, Kathy, Morgan, John C., Jungerman, Joanna M., Cox, Abby, Moore, Miranda A., Ingram, Bryshia, Pier, Ellyn, Johnson, Theodore M., Loring, David W., Hepburn, Kenneth, Medders, Laura, Levey, Allan I., Lah, James J., Hales, Chadwick M.
Publicado 2022

CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual

por Yun, Yeomin, Hong, Sung-Ah, Kim, Ka-Kyung, Baek, Daye, Lee, Dongsu, Londhe, Ashwini M., Lee, Minhyung, Yu, Jihyeon, McEachin, Zachary T., Bassell, Gary J., Bowser, Robert, Hales, Chadwick M., Cho, Sung-Rae, Kim, Janghwan, Pae, Ae Nim, Cheong, Eunji, Kim, Sangwoo, Boulis, Nicholas M., Bae, Sangsu, Ha, Yoon
Publicado 2020

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

por Raj, Nisha, McEachin, Zachary T., Harousseau, William, Zhou, Ying, Zhang, Feiran, Merritt-Garza, Megan E., Taliaferro, J. Matthew, Kalinowska, Magdalena, Marro, Samuele G., Hales, Chadwick M., Berry-Kravis, Elizabeth, Wolf-Ochoa, Marisol W., Martinez-Cerdeño, Veronica, Wernig, Marius, Chen, Lu, Klann, Eric, Warren, Stephen T., Jin, Peng, Wen, Zhexing, Bassell, Gary J.
Publicado 2021

Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer’s Disease

por Tandon, Raghav, Zhao, Liping, Watson, Caroline M., Elmor, Morgan, Heilman, Craig, Sanders, Katherine, Hales, Chadwick M., Yang, Huiying, Loring, David W., Goldstein, Felicia C., Hanfelt, John J., Duong, Duc M., Johnson, Erik C.B., Wingo, Aliza P., Wingo, Thomas S., Roberts, Blaine R., Seyfried, Nicholas T., Levey, Allan I., Mitchell, Cassie S., Lah, James J.
Publicado 2023

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

por Chou, Ching-Chieh, Zhang, Yi, Umoh, Mfon E., Vaughan, Spencer W., Lorenzini, Ileana, Liu, Feilin, Sayegh, Melissa, Donlin-Asp, Paul G., Chen, Yu Han, Duong, Duc M., Seyfried, Nicholas T., Powers, Maureen A., Kukar, Thomas, Hales, Chadwick M., Gearing, Marla, Cairns, Nigel J., Boylan, Kevin B., Dickson, Dennis W., Rademakers, Rosa, Zhang, Yong-Jie, Petrucelli, Leonard, Sattler, Rita, Zarnescu, Daniela C., Glass, Jonathan D., Rossoll, Wilfried
Publicado 2018