Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of δ opioid receptors in mice

por Singleton, Sam, Sneddon, Claire, Bakina, Alice, Lambert, Jeremy J., Hales, Tim G.
Publicado 2023

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy

por John, Scott, Walwyn, David R., DeFea, Kathryn, Hales, Tim G., Walwyn, Wendy
Publicado 2023

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src

por Bull, Fiona A., Baptista-Hon, Daniel T., Lambert, Jeremy J., Walwyn, Wendy, Hales, Tim G.
Publicado 2017

The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning

por Sharma, Kirti Kumari, Hales, Tim G., Rao, Vaidya Jayathirtha, NicDaeid, Niamh, McKenzie, Craig
Publicado 2018

Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2

por Lam, Hoa, Maga, Matthew, Pradhan, Amynah, Evans, Christopher J, Maidment, Nigel T, Hales, Tim G, Walwyn, Wendy
Publicado 2011

Mutagenic Analysis of the Intracellular Portals of the Human 5-HT(3)A Receptor

por Carland, Jane E., Cooper, Michelle A., Livesey, Matthew R., Hales, Tim G., Peters, John A., Lambert, Jeremy J.
Publicado 2013

Cross-sectional study examining the epidemiology of chronic pain in Nepal

por Higgins, Cassie, Sharma, Saurab, Bimali, Inosha, Hales, Tim G., Cameron, Paul A., Smith, Blair H., Colvin, Lesley A.
Publicado 2023

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

por Dawson, Alice, Trumper, Paul, de Souza, Juliana Oliveira, Parker, Holly, Jones, Mathew J., Hales, Tim G., Hunter, William N.
Publicado 2019

Activation of μ‐opioid receptors by MT‐45 (1‐cyclohexyl‐4‐(1,2‐diphenylethyl)piperazine) and its fluorinated derivatives

por Baptista‐Hon, Daniel T., Smith, Mark, Singleton, Samuel, Antonides, Lysbeth H., Nic Daeid, Niamh, McKenzie, Craig, Hales, Tim G.
Publicado 2020

Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

por Lopez-Charcas, Osbaldo, Pukkanasut, Piyasuda, Velu, Sadanandan E., Brackenbury, William J., Hales, Tim G., Besson, Pierre, Gomora, Juan Carlos, Roger, Sébastien
Publicado 2021

Structural Determinants of Ca(2+) Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor

por Livesey, Matthew R., Cooper, Michelle A., Deeb, Tarek Z., Carland, Jane E., Kozuska, Janna, Hales, Tim. G., Lambert, Jeremy J., Peters, John A.
Publicado 2008

Voltage-gated Na(+) Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

por House, Carrie D., Wang, Bi-Dar, Ceniccola, Kristin, Williams, Russell, Simaan, May, Olender, Jacqueline, Patel, Vyomesh, Baptista-Hon, Daniel T., Annunziata, Christina M., Silvio Gutkind, J., Hales, Tim G., Lee, Norman H.
Publicado 2015

Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes

por Kuo, Chien-Wen S., Dobi, Sara, Gök, Caglar, Da Silva Costa, Ana, Main, Alice, Robertson-Gray, Olivia, Baptista-Hon, Daniel, Wypijewski, Krzysztof J., Costello, Hannah, Hales, Tim G., MacQuaide, Niall, Smith, Godfrey L., Fuller, William
Publicado 2023

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

por Meng, Weihua, Chan, Brian W, Harris, Cameron, Freidin, Maxim B, Hebert, Harry L, Adams, Mark J, Campbell, Archie, Hayward, Caroline, Zheng, Hua, Zhang, Xianwei, Colvin, Lesley A, Hales, Tim G, Palmer, Colin N A, Williams, Frances M K, McIntosh, Andrew, Smith, Blair H
Publicado 2020

How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence

por Forget, Patrice, Aguirre, Jose A., Bencic, Ivanka, Borgeat, Alain, Cama, Allessandro, Condron, Claire, Eintrei, Christina, Eroles, Pilar, Gupta, Anil, Hales, Tim G., Ionescu, Daniela, Johnson, Mark, Kabata, Pawel, Kirac, Iva, Ma, Daqing, Mokini, Zhirajr, Guerrero Orriach, Jose Luis, Retsky, Michael, Sandrucci, Sergio, Siekmann, Wiebke, Štefančić, Ljilja, Votta-Vellis, Gina, Connolly, Cara, Buggy, Donal
Publicado 2019