The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal

por Halestrap, Andrew P.
Publicado 2014

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore

por Varanyuwatana, Pinadda, Halestrap, Andrew P.
Publicado 2012

Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

por Richardson, Andrew P., Halestrap, Andrew P.
Publicado 2016

The role of mitochondria in protection of the heart by preconditioning

por Halestrap, Andrew P., Clarke, Samantha J., Khaliulin, Igor
Publicado 2007

Consecutive pharmacological activation of PKA and PKC mimics the potent cardioprotection of temperature preconditioning

por Khaliulin, Igor, Parker, Joanna E., Halestrap, Andrew P.
Publicado 2010

Temperature preconditioning is optimal at 26°C and confers additional protection to hypothermic cardioplegic ischemic arrest

por Khaliulin, Igor, Halestrap, Andrew P, Suleiman, M-Saadeh
Publicado 2011

Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity

por Nancolas, Bethany, Sessions, Richard B., Halestrap, Andrew P.
Publicado 2015

The role of hexokinase in cardioprotection – mechanism and potential for translation

por Halestrap, Andrew P, Pereira, Gonçalo C, Pasdois, Philippe
Publicado 2015

Real-Time Fluorescence Measurements of ROS and [Ca(2+)] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by...

por Andrienko, Tatyana, Pasdois, Philippe, Rossbach, Andreas, Halestrap, Andrew P
Publicado 2016

The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic...

por Manoharan, Christine, Wilson, Marieangela C., Sessions, Richard B., Halestrap, Andrew P.
Publicado 2006

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

por Pasdois, Philippe, Parker, Joanne E., Griffiths, Elinor J., Halestrap, Andrew P.
Publicado 2011

Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle

por Wilson, Marieangela C., Meredith, David, Bunnun, Chotirote, Sessions, Richard B., Halestrap, Andrew P.
Publicado 2009

Switching Back to Normal Diet Following High-Fat Diet Feeding Reduces Cardiac Vulnerability to Ischaemia and Reperfusion Injury

por Littlejohns, Ben, Lin, Hua, Angelini, Gianni D., Halestrap, Andrew P., Suleiman, M. Saadeh
Publicado 2014

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

por Ovens, Matthew J., Manoharan, Christine, Wilson, Marieangela C., Murray, Clarey M., Halestrap, Andrew P.
Publicado 2010

The role of succinate and ROS in reperfusion injury – A critical appraisal

por Andrienko, Tatyana N., Pasdois, Philippe, Pereira, Gonçalo C., Ovens, Matthew J., Halestrap, Andrew P.
Publicado 2017

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

por Ovens, Matthew J., Davies, Andrew J., Wilson, Marieangela C., Murray, Clare M., Halestrap, Andrew P.
Publicado 2010

Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-Cells Leads to Relative Hyperinsulinism During Exercise

por Pullen, Timothy J., Sylow, Lykke, Sun, Gao, Halestrap, Andrew P., Richter, Erik A., Rutter, Guy A.
Publicado 2012

Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

por Khaliulin, Igor, Halestrap, Andrew P, Bryant, Simon M, Dudley, Declan J, James, Andrew F, Suleiman, M-Saadeh
Publicado 2014

The Neuroplastin Adhesion Molecules Are Accessory Proteins That Chaperone the Monocarboxylate Transporter MCT2 to the Neuronal Cell Surface

por Wilson, Marieangela C., Kraus, Michaela, Marzban, Hassan, Sarna, Justyna R., Wang, Yisong, Hawkes, Richard, Halestrap, Andrew P., Beesley, Philip W.
Publicado 2013

Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia

por Pereira, Gonçalo C., Lee, Laura, Rawlings, Nadiia, Ouwendijk, Joke, Parker, Joanne E., Andrienko, Tatyana N., Henley, Jeremy M., Halestrap, Andrew P.
Publicado 2020