Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

por Hall, Belinda S., Bot, Christopher, Wilkinson, Shane R.
Publicado 2011

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

por Hall, Belinda S., Hsieh, Louise Tzung-Harn, Sacre, Sandra, Simmonds, Rachel E.
Publicado 2022

Cognitive Enrichment in Practice: A Survey of Factors Affecting Its Implementation in Zoos Globally

por Hall, Belinda A., McGill, David M., Sherwen, Sally L., Doyle, Rebecca E.
Publicado 2021

Curious creatures: a multi-taxa investigation of responses to novelty in a zoo environment

por Hall, Belinda A., Melfi, Vicky, Burns, Alicia, McGill, David M., Doyle, Rebecca E.
Publicado 2018

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

por Hall, Belinda S., Hill, Kirsti, McKenna, Michael, Ogbechi, Joy, High, Stephen, Willis, Anne E., Simmonds, Rachel E.
Publicado 2014

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

por Ogbechi, Joy, Hall, Belinda S., Sbarrato, Thomas, Taunton, Jack, Willis, Anne E., Wek, Ronald C., Simmonds, Rachel E.
Publicado 2018

The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

por Ridewood, Sophie, Ooi, Cher‐Pheng, Hall, Belinda, Trenaman, Anna, Wand, Nadina Vasileva, Sioutas, Georgios, Scherwitzl, Iris, Rudenko, Gloria
Publicado 2017

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei

por Davies, Carys, Ooi, Cher-Pheng, Sioutas, Georgios, Hall, Belinda S, Sidhu, Haneesh, Butter, Falk, Alsford, Sam, Wickstead, Bill, Rudenko, Gloria
Publicado 2021

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

por Mejia, Ana Maria, Hall, Belinda S., Taylor, Martin C., Gómez-Palacio, Andrés, Wilkinson, Shane R., Triana-Chávez, Omar, Kelly, John M.
Publicado 2012

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

por Hall, Belinda S, Dos Santos, Scott J, Hsieh, Louise Tzung-Harn, Manifava, Maria, Ruf, Marie-Thérèse, Pluschke, Gerd, Ktistakis, Nicholas, Simmonds, Rachel E
Publicado 2021

Murine Norovirus Infection Results in Anti-inflammatory Response Downstream of Amino Acid Depletion in Macrophages

por Brocard, Michèle, Lu, Jia, Hall, Belinda, Borah, Khushboo, Moller-Levet, Carla, Georgana, Iliana, Sorgeloos, Frederic, Beste, Dany J. V., Goodfellow, Ian G., Locker, Nicolas
Publicado 2021

Mycolactone enhances the Ca(2+) leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca(2+) permeable state

por Bhadra, Pratiti, Dos Santos, Scott, Gamayun, Igor, Pick, Tillman, Neumann, Clarissa, Ogbechi, Joy, Hall, Belinda S., Zimmermann, Richard, Helms, Volkhard, Simmonds, Rachel E., Cavalié, Adolfo
Publicado 2021

Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans...

por Hsieh, Louise Tzung-Harn, Hall, Belinda S., Newcombe, Jane, Mendum, Tom A., Umrania, Yagnesh, Deery, Michael J., Shi, Wei Q., Salguero, Francisco J., Simmonds, Rachel E
Publicado 2023

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

por Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S., Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T., Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E.
Publicado 2015

Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation

por Brocard, Michèle, Iadevaia, Valentina, Klein, Philipp, Hall, Belinda, Lewis, Glenys, Lu, Jia, Burke, James, Willcocks, Margaret M., Parker, Roy, Goodfellow, Ian G., Ruggieri, Alessia, Locker, Nicolas
Publicado 2020

Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

por Hsieh, Louise Tzung-Harn, Dos Santos, Scott J., Hall, Belinda S., Ogbechi, Joy, Loglo, Aloysius D., Salguero, Francisco Javier, Ruf, Marie-Thérèse, Pluschke, Gerd, Simmonds, Rachel E.
Publicado 2022

Structure of the Inhibited State of the Sec Translocon

por Gérard, Samuel F., Hall, Belinda S., Zaki, Afroditi M., Corfield, Katherine A., Mayerhofer, Peter U., Costa, Catia, Whelligan, Daniel K., Biggin, Philip C., Simmonds, Rachel E., Higgins, Matthew K.
Publicado 2020

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma bru...

por de Carvalho, Alcione Silva, Salomão, Kelly, de Castro, Solange Lisboa, Conde, Taline Ramos, Zamith, Helena Pereira da Silva, Caffarena, Ernesto Raúl, Hall, Belinda Suzette, Wilkinson, Shane Robert, Boechat, Núbia
Publicado 2014

Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei

por Budzak, James, Kerry, Louise E., Aristodemou, Aris, Hall, Belinda S., Witmer, Kathrin, Kushwaha, Manish, Davies, Carys, Povelones, Megan L., McDonald, Jacquelyn R., Sur, Aakash, Myler, Peter J., Rudenko, Gloria
Publicado 2019

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

por O’Keefe, Sarah, Bhadra, Pratiti, Duah, Kwabena B., Zong, Guanghui, Tenay, Levise, Andrews, Lauren, Schneider, Hayden, Anderson, Ashley, Hu, Zhijian, Aljewari, Hazim S., Hall, Belinda S., Simmonds, Rachel E., Helms, Volkhard, High, Stephen, Shi, Wei Q.
Publicado 2022