Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

por Hall, Kelsi R, Robins, Katherine J, Williams, Elsie M, Rich, Michelle H, Calcott, Mark J, Copp, Janine N, Little, Rory F, Schwörer, Ralf, Evans, Gary B, Patrick, Wayne M, Ackerley, David F
Publicado 2020

A Conserved Second Sphere Residue Tunes Copper Site Reactivity in Lytic Polysaccharide Monooxygenases

por Hall, Kelsi R., Joseph, Chris, Ayuso-Fernández, Iván, Tamhankar, Ashish, Rieder, Lukas, Skaali, Rannei, Golten, Ole, Neese, Frank, Røhr, Åsmund K., Jannuzzi, Sergio A. V., DeBeer, Serena, Eijsink, Vincent G. H., Sørlie, Morten
Publicado 2023

NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

por Sharrock, Abigail V., Mulligan, Timothy S., Hall, Kelsi R., Williams, Elsie M., White, David T., Zhang, Liyun, Emmerich, Kevin, Matthews, Frazer, Nimmagadda, Saumya, Washington, Selena, Le, Katherine D., Meir-Levi, Danielle, Cox, Olivia L., Saxena, Meera T., Calof, Anne L., Lopez-Burks, Martha E., Lander, Arthur D., Ding, Ding, Ji, Hongkai, Ackerley, David F., Mumm, Jeff S.
Publicado 2022

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

por Zhang, Liyun, Chen, Conan, Fu, Jie, Lilley, Brendan, Berlinicke, Cynthia, Hansen, Baranda, Ding, Ding, Wang, Guohua, Wang, Tao, Shou, Daniel, Ye, Ying, Mulligan, Timothy, Emmerich, Kevin, Saxena, Meera T, Hall, Kelsi R, Sharrock, Abigail V, Brandon, Carlene, Park, Hyejin, Kam, Tae-In, Dawson, Valina L, Dawson, Ted M, Shim, Joong Sup, Hanes, Justin, Ji, Hongkai, Liu, Jun O, Qian, Jiang, Ackerley, David F, Rohrer, Baerbel, Zack, Donald J, Mumm, Jeff S
Publicado 2021