Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease

por Hallett, Penelope J., Engelender, Simone, Isacson, Ole
Publicado 2019

Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease

por Isacson, Ole, Brekk, Oeystein R., Hallett, Penelope J.
Publicado 2019

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

por Brekk, Oeystein R., Moskites, Alyssa, Isacson, Ole, Hallett, Penelope J.
Publicado 2018

Advantages and Recent Developments of Autologous Cell Therapy for Parkinson’s Disease Patients

por Osborn, Teresia M., Hallett, Penelope J., Schumacher, James M., Isacson, Ole
Publicado 2020

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

por Thomas, Ria, Moloney, Elizabeth B., Macbain, Zachary K., Hallett, Penelope J., Isacson, Ole
Publicado 2021

Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

por Brekk, Oeystein Roed, Honey, Jonathan R., Lee, Seungil, Hallett, Penelope J., Isacson, Ole
Publicado 2020

Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson’s disease

por Kumar, Manoj, Srikanth, Manasa P, Deleidi, Michela, Hallett, Penelope J, Isacson, Ole, Feldman, Ricardo A
Publicado 2023

Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

por Connolly, Kyle J., Margaria, Juliette, Di Biase, Erika, Cooper, Oliver, Hallett, Penelope J., Isacson, Ole
Publicado 2023

Progressive decline of glucocerebrosidase in aging and Parkinson's disease

por Rocha, Emily M, Smith, Gaynor A, Park, Eric, Cao, Hongmei, Brown, Eilish, Hallett, Penelope, Isacson, Ole
Publicado 2015

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain

por Thomas, Ria, Connolly, Kyle J., Brekk, Oeystein R., Hinrich, Anthony J., Hastings, Michelle L., Isacson, Ole, Hallett, Penelope J.
Publicado 2023

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

por Huebecker, Mylene, Moloney, Elizabeth B., van der Spoel, Aarnoud C., Priestman, David A., Isacson, Ole, Hallett, Penelope J., Platt, Frances M.
Publicado 2019

Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

por Huebecker, Mylene, Moloney, Elizabeth B., van der Spoel, Aarnoud C., Priestman, David A., Isacson, Ole, Hallett, Penelope J., Platt, Frances M.
Publicado 2020

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain

por Hallett, Penelope J., Huebecker, Mylene, Brekk, Oeystein R., Moloney, Elizabeth B., Rocha, Emily M., Priestman, David A., Platt, Frances M., Isacson, Ole
Publicado 2018

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

por Korecka, Joanna A., Thomas, Ria, Hinrich, Anthony J., Moskites, Alyssa M., Macbain, Zach K., Hallett, Penelope J., Isacson, Ole, Hastings, Michelle L.
Publicado 2020

Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease

por Wallom, Kerri-Lee, Fernández-Suárez, María E., Priestman, David A., te Vruchte, Danielle, Huebecker, Mylene, Hallett, Penelope J., Isacson, Ole, Platt, Frances M.
Publicado 2021

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

por Davies, Sian E., Hallett, Penelope J., Moens, Thomas, Smith, Gaynor, Mangano, Emily, Kim, Hyoung Tae, Goldberg, Alfred L., Liu, Ji-Long, Isacson, Ole, Tofaris, George K.
Publicado 2014

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

por Smith, Gaynor A., Rocha, Emily M., Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R., Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J., Isacson, Ole
Publicado 2015

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

por Brekk, Oeystein R., Korecka, Joanna A., Crapart, Cecile C., Huebecker, Mylene, MacBain, Zachary K., Rosenthal, Sara Ann, Sena-Esteves, Miguel, Priestman, David A., Platt, Frances M., Isacson, Ole, Hallett, Penelope J.
Publicado 2020

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

por Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R., Hayes, Melissa A., Beagan, Jonathan, Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J., Isacson, Ole
Publicado 2015

Neurite Collapse and Altered ER Ca(2+) Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

por Korecka, Joanna A., Talbot, Sebastien, Osborn, Teresia M., de Leeuw, Sherida M., Levy, Simon A., Ferrari, Eliza J., Moskites, Alyssa, Atkinson, Elise, Jodelka, Francine M., Hinrich, Anthony J., Hastings, Michelle L., Woolf, Clifford J., Hallett, Penelope J., Isacson, Ole
Publicado 2018