Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

por Martinez, Ricardo, Blasina, Alessandra, Hallin, Jill F., Hu, Wenyue, Rymer, Isha, Fan, Jeffery, Hoffman, Robert L., Murphy, Sean, Marx, Matthew, Yanochko, Gina, Trajkovic, Dusko, Dinh, Dac, Timofeevski, Sergei, Zhu, Zhou, Sun, Peiquing, Lappin, Patrick B., Murray, Brion W.
Publicado 2015

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRAS(G12C)-Mutant Non–Small Cell Lung Cancer

por Sabari, Joshua K., Velcheti, Vamsidhar, Shimizu, Kazuhide, Strickland, Matthew R., Heist, Rebecca S., Singh, Mohini, Nayyar, Naema, Giobbie-Hurder, Anita, Digumarthy, Subba R., Gainor, Justin F., Rajan, Anant P., Nieblas-Bedolla, Edwin, Burns, Aaron C., Hallin, Jill, Olson, Peter, Christensen, James G., Kurz, Sylvia C., Brastianos, Priscilla K., Wakimoto, Hiroaki
Publicado 2022

Efficacy of a Small-Molecule Inhibitor of Kras(G12D) in Immunocompetent Models of Pancreatic Cancer

por Kemp, Samantha B., Cheng, Noah, Markosyan, Nune, Sor, Rina, Kim, Il-Kyu, Hallin, Jill, Shoush, Jason, Quinones, Liz, Brown, Natalie V., Bassett, Jared B., Joshi, Nikhil, Yuan, Salina, Smith, Molly, Vostrejs, William P., Perez-Vale, Kia Z., Kahn, Benjamin, Mo, Feiyan, Donahue, Timothy R., Radu, Caius G., Clendenin, Cynthia, Christensen, James G., Vonderheide, Robert H., Stanger, Ben Z.
Publicado 2023

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

por Engstrom, Lars D., Aranda, Ruth, Waters, Laura, Moya, Krystal, Bowcut, Vickie, Vegar, Laura, Trinh, David, Hebbert, Allan, Smith, Christopher R., Kulyk, Svitlana, Lawson, J. David, He, Leo, Hover, Laura D., Fernandez-Banet, Julio, Hallin, Jill, Vanderpool, Darin, Briere, David M., Blaj, Alice, Marx, Matthew A., Rodon, Jordi, Offin, Michael, Arbour, Kathryn C., Johnson, Melissa L., Kwiatkowski, David J., Jänne, Pasi A., Haddox, Candace L., Papadopoulos, Kyriakos P., Henry, Jason T., Leventakos, Konstantinos, Christensen, James G., Shazer, Ronald, Olson, Peter
Publicado 2023