Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity

por Tokatlian, Talar, Asuelime, Grace E., Naradikian, Martin S., Mock, Jee-Young, Daris, Mark E., Martin, Aaron D., Toledo Warshaviak, Dora, Kamb, Alexander, Hamburger, Agnes E.
Publicado 2022

HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen

por Mock, Jee-Young, Winters, Aaron, Riley, Timothy P., Bruno, Richele, Naradikian, Martin S., Sharma, Shruti, Jette, Claudia A., Elshimali, Ryan, Gahrs, Casey, Toledo-Warshaviak, Dora, West, Anthony P., Kamb, Alexander, Hamburger, Agnes E.
Publicado 2022

Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells

por Tokatlian, Talar, Asuelime, Grace E, Mock, Jee-Young, DiAndreth, Breanna, Sharma, Shruti, Toledo Warshaviak, Dora, Daris, Mark E, Bolanos, Kristian, Luna, Breanna L, Naradikian, Martin S, Deshmukh, Kiran, Hamburger, Agnes E, Kamb, Alexander
Publicado 2022

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

por Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R., Alba, Benjamin M., Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W., Véniant, Murielle M., Li, Yang
Publicado 2013