Perturbing Enhancer Activity in Cancer Therapy

por Hamdan, Feda H., Johnsen, Steven A.
Publicado 2019

Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer

por Kutschat, Ana P., Johnsen, Steven A., Hamdan, Feda H.
Publicado 2021

ATRT-07. DEFINING LOST AND GAINED TRANSCRIPTIONAL REGULATORY NETWORKS IN ATYPICAL TERATOID RHABDOID TUMOR

por Nesvick, Cody, Zhang, Liang, Wixom, Alex, Hamdan, Feda, Johnsen, Steven, Daniels, David
Publicado 2021

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer

por Flebbe, Hannah, Hamdan, Feda H., Kari, Vijayalakshmi, Kitz, Julia, Gaedcke, Jochen, Ghadimi, B. Michael, Johnsen, Steven A., Grade, Marian
Publicado 2019

Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas

por Wang, Xin, Kutschat, Ana P., Yamada, Moyuru, Prokakis, Evangelos, Böttcher, Patricia, Tanaka, Koji, Doki, Yuichiro, Hamdan, Feda H., Johnsen, Steven A.
Publicado 2021

Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells

por Wiese, Maria, Hamdan, Feda H., Kubiak, Klaudia, Diederichs, Christopher, Gielen, Gerrit H., Nussbaumer, Gunther, Carcaboso, Angel M., Hulleman, Esther, Johnsen, Steven A., Kramm, Christof M.
Publicado 2020

The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells

por Schneider, Deborah, Chua, Robert Lorenz, Molitor, Nicole, Hamdan, Feda H., Rettenmeier, Eva Maria, Prokakis, Evangelos, Mishra, Vivek Kumar, Kari, Vijayalakshmi, Wegwitz, Florian, Johnsen, Steven A., Kosinsky, Robyn Laura
Publicado 2019

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

por Sen, Madhobi, Wang, Xin, Hamdan, Feda H., Rapp, Jacobe, Eggert, Jessica, Kosinsky, Robyn Laura, Wegwitz, Florian, Kutschat, Ana Patricia, Younesi, Fereshteh S., Gaedcke, Jochen, Grade, Marian, Hessmann, Elisabeth, Papantonis, Argyris, Strӧbel, Philipp, Johnsen, Steven A.
Publicado 2019

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells

por Nagarajan, Sankari, Bedi, Upasana, Budida, Anusha, Hamdan, Feda H., Mishra, Vivek Kumar, Najafova, Zeynab, Xie, Wanhua, Alawi, Malik, Indenbirken, Daniela, Knapp, Stefan, Chiang, Cheng-Ming, Grundhoff, Adam, Kari, Vijayalakshmi, Scheel, Christina H., Wegwitz, Florian, Johnsen, Steven A.
Publicado 2017

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

por Patzak, Melanie S., Kari, Vijayalakshmi, Patil, Shilpa, Hamdan, Feda H., Goetze, Robert G., Brunner, Marius, Gaedcke, Jochen, Kitz, Julia, Jodrell, Duncan I., Richards, Frances M., Pilarsky, Christian, Gruetzmann, Robert, Rümmele, Petra, Knösel, Thomas, Hessmann, Elisabeth, Ellenrieder, Volker, Johnsen, Steven A., Neesse, Albrecht
Publicado 2019

STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma

por Zhang, Liang, Nesvick, Cody L, Day, Charlie A, Choi, Jonghoon, Lu, Victor M, Peterson, Timothy, Power, Erica A, Anderson, Jacob B, Hamdan, Feda H, Decker, Paul A, Simons, Renae, Welby, John P, Siada, Ruby, Ge, Jizhi, Kaptzan, Tatiana, Johnsen, Steven A, Hinchcliffe, Edward H, Daniels, David J
Publicado 2022

Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation

por Jalan‐Sakrikar, Nidhi, De Assuncao, Thiago M., Navarro‐Corcuera, Amaia, Hamdan, Feda H., Loarca, Lorena, Kirkeby, Lindsey A., Resch, Zachary T., O’Hara, Steven P., Juran, Brian D., Lazaridis, Konstantinos N., Rosen, Charles B., Heimbach, Julie K., Taner, Timucin, Shah, Vijay H., LaRusso, Nicholas F., Huebert, Robert C.
Publicado 2021

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis

por Liu, Mengfei, Cao, Sheng, He, Li, Gao, Jinhang, Arab, Juan P., Cui, Huarui, Xuan, Weixia, Gao, Yandong, Sehrawat, Tejasav S., Hamdan, Feda H., Ventura-Cots, Meritxell, Argemi, Josepmaria, Pomerantz, William C. K., Johnsen, Steven A., Lee, Jeong-Heon, Gao, Fei, Ordog, Tamas, Mathurin, Philippe, Revzin, Alexander, Bataller, Ramon, Yan, Huihuang, Shah, Vijay H.
Publicado 2021

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

por Aspros, Kirsten G. M., Carter, Jodi M., Hoskin, Tanya L., Suman, Vera J., Subramaniam, Malayannan, Emch, Michael J., Ye, Zhenqing, Sun, Zhifu, Sinnwell, Jason P., Thompson, Kevin J., Tang, Xiaojia, Rodman, Esther P. B., Wang, Xiyin, Nelson, Adam W., Chernukhin, Igor, Hamdan, Feda H., Bruinsma, Elizabeth S., Carroll, Jason S., Fernandez-Zapico, Martin E., Johnsen, Steven A., Kalari, Krishna R., Huang, Haojie, Leon-Ferre, Roberto A., Couch, Fergus J., Ingle, James N., Goetz, Matthew P., Hawse, John R.
Publicado 2022