Mouse Survival Motor Neuron Alleles That Mimic SMN2 Splicing and Are Inducible Rescue Embryonic Lethality Early in Development but Not Late

por Hammond, Suzan M., Gogliotti, Rocky G., Rao, Vamshi, Beauvais, Ariane, Kothary, Rashmi, DiDonato, Christine J.
Publicado 2010

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy

por Shabanpoor, Fazel, Hammond, Suzan M, Abendroth, Frank, Hazell, Gareth, Wood, Matthew J.A., Gait, Michael J.
Publicado 2017

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment

por Gait, Michael J., Arzumanov, Andrey A., McClorey, Graham, Godfrey, Caroline, Betts, Corinne, Hammond, Suzan, Wood, Matthew J.A.
Publicado 2019

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

por Betts, Corinne, Saleh, Amer F, Arzumanov, Andrey A, Hammond, Suzan M, Godfrey, Caroline, Coursindel, Thibault, Gait, Michael J, Wood, Matthew JA
Publicado 2012

Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

por Ahlskog, Nina, Hayler, Daniel, Krueger, Anja, Kubinski, Sabrina, Claus, Peter, Hammond, Suzan M., Wood, Matthew J. A., Yáñez-Muñoz, Rafael J., Bowerman, Melissa
Publicado 2020

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy

por Hammond, Suzan M., Abendroth, Frank, Goli, Larissa, Stoodley, Jessica, Burrell, Matthew, Thom, George, Gurrell, Ian, Ahlskog, Nina, Gait, Michael J., Wood, Matthew J.A., Webster, Carl I.
Publicado 2022

Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy

por Winkelsas, Audrey M., Grunseich, Christopher, Harmison, George G., Chwalenia, Katarzyna, Rinaldi, Carlo, Hammond, Suzan M., Johnson, Kory, Bowerman, Melissa, Arya, Sukrat, Talbot, Kevin, Wood, Matthew J., Fischbeck, Kenneth H.
Publicado 2021

PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice

por Kordala, Anna J, Stoodley, Jessica, Ahlskog, Nina, Hanifi, Muhammad, Garcia Guerra, Antonio, Bhomra, Amarjit, Lim, Wooi Fang, Murray, Lyndsay M, Talbot, Kevin, Hammond, Suzan M, Wood, Matthew JA, Rinaldi, Carlo
Publicado 2023

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

por Meijboom, Katharina E., Volpato, Viola, Monzón-Sandoval, Jimena, Hoolachan, Joseph M., Hammond, Suzan M., Abendroth, Frank, de Jong, Olivier G., Hazell, Gareth, Ahlskog, Nina, Wood, Matthew J.A., Webber, Caleb, Bowerman, Melissa
Publicado 2021

Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides

por Järver, Peter, Zaghloul, Eman M., Arzumanov, Andrey A., Saleh, Amer F., McClorey, Graham, Hammond, Suzan M., Hällbrink, Mattias, Langel, Ülo, Smith, C.I. Edvard, Wood, Matthew J.A., Gait, Michael J., EL Andaloussi, Samir
Publicado 2015

Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy

por Betts, Corinne A., Saleh, Amer F., Carr, Carolyn A., Muses, Sofia, Wells, Kim E., Hammond, Suzan M., Godfrey, Caroline, McClorey, Graham, Woffindale, Caroline, Clarke, Kieran, Wells, Dominic J., Gait, Michael J., Wood, Matthew J. A.
Publicado 2015

Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice

por Betts, Corinne A., Saleh, Amer F., Carr, Carolyn A., Hammond, Suzan M., Coenen-Stass, Anna M. L., Godfrey, Caroline, McClorey, Graham, Varela, Miguel A., Roberts, Thomas C., Clarke, Kieran, Gait, Michael J., Wood, Matthew J. A.
Publicado 2015

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides

por Hammond, Suzan M, McClorey, Graham, Nordin, Joel Z, Godfrey, Caroline, Stenler, Sofia, Lennox, Kim A, Smith, CI Edvard, Jacobi, Ashley M, Varela, Miguel A, Lee, Yi, Behlke, Mark A, Wood, Matthew J A, Andaloussi, Samir E L
Publicado 2014

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment

por Betts, Corinne A, McClorey, Graham, Healicon, Richard, Hammond, Suzan M, Manzano, Raquel, Muses, Sofia, Ball, Vicky, Godfrey, Caroline, Merritt, Thomas M, van Westering, Tirsa, O’Donovan, Liz, Wells, Kim E, Gait, Michael J, Wells, Dominic J, Tyler, Damian, Wood, Matthew J
Publicado 2019

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

por Ezzat, Kariem, EL Andaloussi, Samir, Zaghloul, Eman M., Lehto, Taavi, Lindberg, Staffan, Moreno, Pedro M. D., Viola, Joana R., Magdy, Tarek, Abdo, Rania, Guterstam, Peter, Sillard, Rannar, Hammond, Suzan M., Wood, Matthew J. A., Arzumanov, Andrey A., Gait, Michael J., Smith, C. I. Edvard, Hällbrink, Mattias, Langel, Ülo
Publicado 2011

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

por Walter, Lisa M., Deguise, Marc-Olivier, Meijboom, Katharina E., Betts, Corinne A., Ahlskog, Nina, van Westering, Tirsa L.E., Hazell, Gareth, McFall, Emily, Kordala, Anna, Hammond, Suzan M., Abendroth, Frank, Murray, Lyndsay M., Shorrock, Hannah K., Prosdocimo, Domenick A., Haldar, Saptarsi M., Jain, Mukesh K., Gillingwater, Thomas H., Claus, Peter, Kothary, Rashmi, Wood, Matthew J.A., Bowerman, Melissa
Publicado 2018

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

por Hammond, Suzan M, Aartsma‐Rus, Annemieke, Alves, Sandra, Borgos, Sven E, Buijsen, Ronald A M, Collin, Rob W J, Covello, Giuseppina, Denti, Michela A, Desviat, Lourdes R, Echevarría, Lucía, Foged, Camilla, Gaina, Gisela, Garanto, Alejandro, Goyenvalle, Aurelie T, Guzowska, Magdalena, Holodnuka, Irina, Jones, David R, Krause, Sabine, Lehto, Taavi, Montolio, Marisol, Van Roon‐Mom, Willeke, Arechavala‐Gomeza, Virginia
Publicado 2021