Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications

por Noridomi, Kaori, Watanabe, Go, Hansen, Melissa N, Han, Gye Won, Chen, Lin
Publicado 2017

Structural basis of the activation of a metabotropic GABA receptor

por Shaye, Hamidreza, Ishchenko, Andrii, Lam, Jordy Homing, Han, Gye Won, Xue, Li, Rondard, Philippe, Pin, Jean-Philippe, Katritch, Vsevolod, Gati, Cornelius, Cherezov, Vadim
Publicado 2020

The activation mechanism and antibody binding mode for orphan GPR20

por Lin, Xi, Jiang, Shan, Wu, Yiran, Wei, Xiaohu, Han, Gye-Won, Wu, Lijie, Liu, Junlin, Chen, Bo, Zhang, Zhibin, Zhao, Suwen, Cherezov, Vadim, Xu, Fei
Publicado 2023

Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase

por Lee, Ming-Yue, Geiger, James, Ishchenko, Andrii, Han, Gye Won, Barty, Anton, White, Thomas A., Gati, Cornelius, Batyuk, Alexander, Hunter, Mark S., Aquila, Andrew, Boutet, Sébastien, Weierstall, Uwe, Cherezov, Vadim, Liu, Wei
Publicado 2020

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G(s)

por Xu, Lu, Chen, Bo, Schihada, Hannes, Wright, Shane C., Turku, Ainoleena, Wu, Yiran, Han, Gye-Won, Kowalski-Jahn, Maria, Kozielewicz, Pawel, Bowin, Carl-Fredrik, Zhang, Xianjun, Li, Chao, Bouvier, Michel, Schulte, Gunnar, Xu, Fei
Publicado 2021

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

por Michaelian, Nairie, Sadybekov, Anastasiia, Besserer-Offroy, Élie, Han, Gye Won, Krishnamurthy, Harini, Zamlynny, Beata A., Fradera, Xavier, Siliphaivanh, Phieng, Presland, Jeremy, Spencer, Kerrie B., Soisson, Stephen M., Popov, Petr, Sarret, Philippe, Katritch, Vsevolod, Cherezov, Vadim
Publicado 2021

Full-length human GLP-1 receptor structure without orthosteric ligands

por Wu, Fan, Yang, Linlin, Hang, Kaini, Laursen, Mette, Wu, Lijie, Han, Gye Won, Ren, Qiansheng, Roed, Nikolaj Kulahin, Lin, Guangyao, Hanson, Michael A., Jiang, Hualiang, Wang, Ming-Wei, Reedtz-Runge, Steffen, Song, Gaojie, Stevens, Raymond C.
Publicado 2020

Toward G protein-coupled receptor structure-based drug design using X-ray lasers

por Ishchenko, Andrii, Stauch, Benjamin, Han, Gye Won, Batyuk, Alexander, Shiriaeva, Anna, Li, Chufeng, Zatsepin, Nadia, Weierstall, Uwe, Liu, Wei, Nango, Eriko, Nakane, Takanori, Tanaka, Rie, Tono, Kensuke, Joti, Yasumasa, Iwata, So, Moraes, Isabel, Gati, Cornelius, Cherezov, Vadim
Publicado 2019

Structure of the human kappa opioid receptor in complex with JDTic

por Wu, Huixian, Wacker, Daniel, Katritch, Vsevolod, Mileni, Mauro, Han, Gye Won, Vardy, Eyal, Liu, Wei, Thompson, Aaron A., Huang, Xi-Ping, Carroll, F. Ivy, Mascarella, S. Wayne, Westkaemper, Richard B., Mosier, Philip D., Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Publicado 2012

Agonist-bound structure of the human P2Y(12) receptor

por Zhang, Jin, Zhang, Kaihua, Gao, Zhan-Guo, Paoletta, Silvia, Zhang, Dandan, Han, Gye Won, Li, Tingting, Ma, Limin, Zhang, Wenru, Müller, Christa E., Yang, Huaiyu, Jiang, Hualiang, Cherezov, Vadim, Katritch, Vsevolod, Jacobson, Kenneth A., Stevens, Raymond C., Wu, Beili, Zhao, Qiang
Publicado 2014

GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A(2A) Adenosine Receptor

por Shiriaeva, Anna, Park, Daejin, Kim, Gyudong, Lee, Yoonji, Hou, Xiyan, Jarhad, Dnyandev B., Kim, Gibae, Yu, Jinha, Hyun, Young Eum, Kim, Woomi, Gao, Zhan-Guo, Jacobson, Kenneth A., Han, Gye Won, Stevens, Raymond C., Jeong, Lak Shin, Choi, Sun, Cherezov, Vadim
Publicado 2022

Crystal structure of misoprostol bound to the labor inducer prostaglandin E(2) receptor

por Audet, Martin, White, Kate L., Breton, Billy, Zarzycka, Barbara, Han, Gye Won, Lu, Yan, Gati, Cornelius, Batyuk, Alexander, Popov, Petr, Velasquez, Jeffrey, Manahan, David, Hu, Hao, Weierstall, Uwe, Liu, Wei, Shui, Wenqing, Katritch, Vsevolod, Cherezov, Vadim, Hanson, Michael A., Stevens, Raymond C.
Publicado 2018

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

por Zheng, Yi, Qin, Ling, Ortiz Zacarías, Natalia V., de Vries, Henk, Han, Gye Won, Gustavsson, Martin, Dabros, Marta, Zhao, Chunxia, Cherney, Robert J., Carter, Percy, Stamos, Dean, Abagyan, Ruben, Cherezov, Vadim, Stevens, Raymond C., IJzerman, Adriaan P., Heitman, Laura H., Tebben, Andrew, Kufareva, Irina, Handel, Tracy M.
Publicado 2016

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

por Zhang, Xianjun, Zhao, Fei, Wu, Yiran, Yang, Jun, Han, Gye Won, Zhao, Suwen, Ishchenko, Andrii, Ye, Lintao, Lin, Xi, Ding, Kang, Dharmarajan, Venkatasubramanian, Griffin, Patrick R., Gati, Cornelius, Nelson, Garrett, Hunter, Mark S., Hanson, Michael A., Cherezov, Vadim, Stevens, Raymond C., Tan, Wenfu, Tao, Houchao, Xu, Fei
Publicado 2017

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

por Claff, Tobias, Yu, Jing, Blais, Véronique, Patel, Nilkanth, Martin, Charlotte, Wu, Lijie, Han, Gye Won, Holleran, Brian J., Van der Poorten, Olivier, White, Kate L., Hanson, Michael A., Sarret, Philippe, Gendron, Louis, Cherezov, Vadim, Katritch, Vsevolod, Ballet, Steven, Liu, Zhi-Jie, Müller, Christa E., Stevens, Raymond C.
Publicado 2019

Structural insights into the human niacin receptor HCA2-G(i) signalling complex

por Yang, Yang, Kang, Hye Jin, Gao, Ruogu, Wang, Jingjing, Han, Gye Won, DiBerto, Jeffrey F., Wu, Lijie, Tong, Jiahui, Qu, Lu, Wu, Yiran, Pileski, Ryan, Li, Xuemei, Zhang, Xuejun Cai, Zhao, Suwen, Kenakin, Terry, Wang, Quan, Stevens, Raymond C., Peng, Wei, Roth, Bryan L., Rao, Zihe, Liu, Zhi-Jie
Publicado 2023

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

por Gusach, Anastasiia, Luginina, Aleksandra, Marin, Egor, Brouillette, Rebecca L., Besserer-Offroy, Élie, Longpré, Jean-Michel, Ishchenko, Andrii, Popov, Petr, Patel, Nilkanth, Fujimoto, Taku, Maruyama, Toru, Stauch, Benjamin, Ergasheva, Margarita, Romanovskaia, Daria, Stepko, Anastasiia, Kovalev, Kirill, Shevtsov, Mikhail, Gordeliy, Valentin, Han, Gye Won, Katritch, Vsevolod, Borshchevskiy, Valentin, Sarret, Philippe, Mishin, Alexey, Cherezov, Vadim
Publicado 2019

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

por Luginina, Aleksandra, Gusach, Anastasiia, Marin, Egor, Mishin, Alexey, Brouillette, Rebecca, Popov, Petr, Shiriaeva, Anna, Besserer-Offroy, Élie, Longpré, Jean-Michel, Lyapina, Elizaveta, Ishchenko, Andrii, Patel, Nilkanth, Polovinkin, Vitaly, Safronova, Nadezhda, Bogorodskiy, Andrey, Edelweiss, Evelina, Hu, Hao, Weierstall, Uwe, Liu, Wei, Batyuk, Alexander, Gordeliy, Valentin, Han, Gye Won, Sarret, Philippe, Katritch, Vsevolod, Borshchevskiy, Valentin, Cherezov, Vadim
Publicado 2019

Native phasing of x-ray free-electron laser data for a G protein–coupled receptor

por Batyuk, Alexander, Galli, Lorenzo, Ishchenko, Andrii, Han, Gye Won, Gati, Cornelius, Popov, Petr A., Lee, Ming-Yue, Stauch, Benjamin, White, Thomas A., Barty, Anton, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Boutet, Sébastien, Pu, Mengchen, Liu, Zhi-jie, Nelson, Garrett, James, Daniel, Li, Chufeng, Zhao, Yun, Spence, John C. H., Liu, Wei, Fromme, Petra, Katritch, Vsevolod, Weierstall, Uwe, Stevens, Raymond C., Cherezov, Vadim
Publicado 2016

Structural Basis for Selectivity and Diversity in Angiotensin II Receptors

por Zhang, Haitao, Han, Gye Won, Batyuk, Alexander, Ishchenko, Andrii, White, Kate L., Patel, Nilkanth, Sadybekov, Anastasiia, Zamlynny, Beata, Rudd, Michael T., Hollenstein, Kaspar, Tolstikova, Alexandra, White, Thomas A., Hunter, Mark S., Weierstall, Uwe, Liu, Wei, Babaoglu, Kerim, Moore, Eric L., Katz, Ryan D., Shipman, Jennifer M., Garcia-Calvo, Margarita, Sharma, Sujata, Sheth, Payal, Soisson, Stephen M., Stevens, Raymond C., Katritch, Vsevolod, Cherezov, Vadim
Publicado 2017