RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

por East, Philip, Kelly, Gavin P., Biswas, Dhruva, Marani, Michela, Hancock, David C., Creasy, Todd, Sachsenmeier, Kris, Swanton, Charles, Downward, Julian, de Carné Trécesson, Sophie
Publicado 2022

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

por Steckel, Michael, Molina-Arcas, Miriam, Weigelt, Britta, Marani, Michaela, Warne, Patricia H, Kuznetsov, Hanna, Kelly, Gavin, Saunders, Becky, Howell, Michael, Downward, Julian, Hancock, David C
Publicado 2012

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

por Cooley, Rachel, Kara, Neesha, Hui, Ning Sze, Tart, Jonathan, Roustan, Chloë, George, Roger, Hancock, David C., Binkowski, Brock F., Wood, Keith V., Ismail, Mohamed, Downward, Julian
Publicado 2020

AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons

por Soutar, Marc P. M., Kempthorne, Liam, Miyakawa, Shuichi, Annuario, Emily, Melandri, Daniela, Harley, Jasmine, O’Sullivan, Gregory A., Wray, Selina, Hancock, David C., Cookson, Mark R., Downward, Julian, Carlton, Mark, Plun-Favreau, Hélène
Publicado 2018

RAC1(P29S) Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

por Lionarons, Daniël A., Hancock, David C., Rana, Sareena, East, Philip, Moore, Christopher, Murillo, Miguel M., Carvalho, Joana, Spencer-Dene, Bradley, Herbert, Eleanor, Stamp, Gordon, Damry, Djamil, Calado, Dinis P., Rosewell, Ian, Fritsch, Ralph, Neubig, Richard R., Molina-Arcas, Miriam, Downward, Julian
Publicado 2019

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

por Ismail, Mohamed, Martin, Stephen R., George, Roger, Houghton, Francesca, Kelly, Geoff, Chaleil, Raphaël A. G., Anastasiou, Panayiotis, Wang, Xinyue, O’Reilly, Nicola, Federico, Stefania, Joshi, Dhira, Nagaraj, Hemavathi, Cooley, Rachel, Hui, Ning Sze, Molina-Arcas, Miriam, Hancock, David C., Tavassoli, Ali, Downward, Julian
Publicado 2023