NMR Spectroscopic and Bioinformatic Analyses of the LTBP1 C-Terminus Reveal a Highly Dynamic Domain Organisation

por Robertson, Ian B., Handford, Penny A., Redfield, Christina
Publicado 2014

Assembly assay identifies a critical region of human fibrillin-1 required for 10–12 nm diameter microfibril biogenesis

por Jensen, Sacha A., Atwa, Ondine, Handford, Penny A.
Publicado 2021

A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias

por Jensen, Sacha A., Iqbal, Sarah, Bulsiewicz, Alicja, Handford, Penny A.
Publicado 2015

Notch receptor–ligand binding and activation: Insights from molecular studies

por Chillakuri, Chandramouli R., Sheppard, Devon, Lea, Susan M., Handford, Penny A.
Publicado 2012

Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/LTBP Superfamily of Matrix Proteins

por Jensen, Sacha A., Iqbal, Sarah, Lowe, Edward D., Redfield, Christina, Handford, Penny A.
Publicado 2009

(1)H, (13)C and (15)N assignments of the four N-terminal domains of human fibrillin-1

por Yadin, David A., Robertson, Ian B., Jensen, Sacha A., Handford, Penny A., Redfield, Christina
Publicado 2012

(1)H, (13)C and (15)N resonance assignments for the fibrillin-1 EGF2-EGF3-hybrid1-cbEGF1 four-domain fragment

por Robertson, Ian B., Osuch, Isabelle, Yadin, David A., Handford, Penny A., Jensen, Sacha A., Redfield, Christina
Publicado 2013

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

por Weisshuhn, Philip C., Sheppard, Devon, Taylor, Paul, Whiteman, Pat, Lea, Susan M., Handford, Penny A., Redfield, Christina
Publicado 2016

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

por Suckling, Richard J, Korona, Boguslawa, Whiteman, Pat, Chillakuri, Chandramouli, Holt, Laurie, Handford, Penny A, Lea, Susan M
Publicado 2017

The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling

por Martins, Torcato, Meng, Yao, Korona, Boguslawa, Suckling, Richard, Johnson, Steven, Handford, Penny A, Lea, Susan M, Bray, Sarah J
Publicado 2021

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1

por Robertson, Ian B., Dias, Hans F., Osuch, Isabelle H., Lowe, Edward D., Jensen, Sacha A., Redfield, Christina, Handford, Penny A.
Publicado 2017

Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly

por Yadin, David A., Robertson, Ian B., McNaught-Davis, Joanne, Evans, Paul, Stoddart, David, Handford, Penny A., Jensen, Sacha A., Redfield, Christina
Publicado 2013

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

por Chillakuri, Chandramouli R., Sheppard, Devon, Ilagan, Ma. Xenia G., Holt, Laurie R., Abbott, Felicity, Liang, Shaoyan, Kopan, Raphael, Handford, Penny A., Lea, Susan M.
Publicado 2013

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

por Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.
Publicado 2019

Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor

por Whiteman, Pat, de Madrid, Beatriz Hernandez, Taylor, Paul, Li, Demin, Heslop, Rebecca, Viticheep, Nattnee, Tan, Joyce Zi, Shimizu, Hideyuki, Callaghan, Juliana, Masiero, Massimo, Li, Ji Liang, Banham, Alison H., Harris, Adrian L., Lea, Susan M., Redfield, Christina, Baron, Martin, Handford, Penny A.
Publicado 2013

The CD46 and Jagged1 interaction is critical for human T helper 1 immunity

por Le Friec, Gaëlle, Sheppard, Devon, Whiteman, Pat, Karsten, Christian M., Shamoun, Salley Al-Tilib, Laing, Adam, Bugeon, Laurence, Dallman, Margaret J., Melchionna, Teresa, Chillakuri, Chandramouli, Smith, Richard A., Drouet, Christian, Couzi, Lionel, Fremeaux-Bacchi, Veronique, Köhl, Jörg, Waddington, Simon N., McDonnell, James M., Baker, Alastair, Handford, Penny A., Lea, Susan M., Kemper, Claudia
Publicado 2012