Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1

por Morrison, Logan M., Huang, Haoran, Handler, Hillary P., Fu, Min, Bushart, David D., Pappas, Samuel S., Orr, Harry T., Shakkottai, Vikram G.
Publicado 2023

BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

por Rosa, Juao-Guilherme, Hamel, Katherine, Soles, Alyssa, Sheeler, Carrie, Borgenheimer, Ella, Gilliat, Stephen, Sbrocco, Kaelin, Ghanoum, Ferris, Handler, Hillary P., Forster, Colleen, Rainwater, Orion, Cvetanovic, Marija
Publicado 2023

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice

por Rosa, Juao-Guilherme, Hamel, Katherine, Sheeler, Carrie, Borgenheimer, Ella, Gilliat, Stephen, Soles, Alyssa, Ghannoum, Ferris J., Sbrocco, Kaelin, Handler, Hillary P., Rainwater, Orion, Kang, Ryan, Cvetanovic, Marija
Publicado 2022

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1

por Chopra, Ravi, Bushart, David D, Cooper, John P, Yellajoshyula, Dhananjay, Morrison, Logan M, Huang, Haoran, Handler, Hillary P, Man, Luke J, Dansithong, Warunee, Scoles, Daniel R, Pulst, Stefan M, Orr, Harry T, Shakkottai, Vikram G
Publicado 2020

Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment

por O’Callaghan, Brennon, Hofstra, Bente, Handler, Hillary P., Kordasiewicz, Holly B., Cole, Tracy, Duvick, Lisa, Friedrich, Jillian, Rainwater, Orion, Yang, Praseuth, Benneyworth, Michael, Nichols-Meade, Tessa, Heal, Wesley, Ter Haar, Rachel, Henzler, Christine, Orr, Harry T.
Publicado 2020

Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

por Coffin, Stephanie L., Durham, Mark A., Nitschke, Larissa, Xhako, Eder, Brown, Amanda M., Revelli, Jean-Pierre, Gonzalez, Esmeralda Villavicencio, Lin, Tao, Handler, Hillary P., Dai, Yanwan, Trostle, Alexander J., Wan, Ying-Wooi, Liu, Zhandong, Sillitoe, Roy V., Orr, Harry T., Zoghbi, Huda Y.
Publicado 2023

Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

por Coffin, Stephanie L., Durham, Mark A., Nitschke, Larissa, Xhako, Eder, Brown, Amanda M., Revelli, Jean-Pierre, Gonzalez, Esmeralda Villavicencio, Lin, Tao, Handler, Hillary P., Dai, Yanwan, Trostle, Alexander J., Wan, Ying-Wooi, Liu, Zhandong, Sillitoe, Roy V., Orr, Harry T., Zoghbi, Huda Y.
Publicado 2023