Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

por Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W.
Publicado 2020

Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region

por Handlogten, Michael W., Peng, Li, Christian, Elizabeth A., Xu, Weichen, Lin, Shihua, Venkat, Raghavan, Dall’Acqua, William, Ahuja, Sanjeev
Publicado 2020

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability

por Chung, Wai Keen, Russell, Brian, Yang, Yanhong, Handlogten, Michael, Hudak, Suzanne, Cao, Mingyan, Wang, Jihong, Robbins, David, Ahuja, Sanjeev, Zhu, Min
Publicado 2017